ERA-HDHL (2018) - Nutrition and Epigenome

Nutrition & the Epigenome

In February 2018, the JPI HDHL launched the call: "Nutrition & the Epigenome" under the umbrella of ERA-HDHL. The 13 funded projects stared the first half of 2019 for a period of three years.


A more complete understanding of the relationships between nutrition and health is central to deliver the vision of the JPI HDHL. However, even with modern genomics research and current dietary assessment methods, it is challenging to identify the key mechanisms by which diet influences health, and to establish causal relationships and predict outcomes. Investigating the fine regulation of genes, epigenetics, could provide the missing link. Research in this area is expected to provide insights that allow the development and scientific substantiation of intervention strategies for sustaining good health through all life stages and treating nutrition-related diseases.

Aim of the call

The aim of this call is to support transnational, collaborative research projects that gain a better understanding of the diet- epigenome relationships and their effect on human health. Proposals should focus on the diet and epigenome, and cover one of the following areas:

  • Establishing cause-and-effect relationships between diet and epigenome and metabolic health including molecular and cellular mechanisms, its reversibility and long-term effects where feasibile;
  • Identifying risk factors and early stage epigenetic changes involved in the development of metabolic diseases;
  • Epigenetic effects across the lifespan and inter (and potentially trans) generational epigenetic effects;
  • Investigation of modifiable factors (diet, the combined effect of diet and phyiscal activity, microbiota, etc.) that could be involved in epigenetic regulation at critical stages of life;
  • The effect of diet and nutritional status on the intra-uterine environment and its subsequent effect on the fetal epigenome and later health of the child.
Participating countries
Country Funding Organisation Short name
Canada Canadian Institutes of Health Research CIHR
Czech Republic Ministry of Education, Youth and Sports MEYS
France French National Research Agency ANR
Germany Federal Ministry of Education and Research, represented by the Project Management Agency in the German Aerospace Center BMBF
Represented by DLR
Ireland * Health Research Board HRB
Israel * Ministry of Science, Technology and Space MoST
Latvia * Ministry of Education and Science IZM
The Netherlands The Netherlands Organisation for Health Research and Development ZonMw
Poland * The National Centre for Research and Development NCBR
Spain National Institute of Health Carlos III ISCIII
Spain Research State Agency (Ministry of Economy, Industry and Competitiveness) AEI (MINECO)
UK Medical Research Council Biotechnology and Biological Sciences Research Council MRC

* Did not fund research projects in this call

Funded projects
Project Coordinator
DIFAMEM Dr. Maria Jose Torres,
Regional University Hospital of Malaga, Spain
DIMENSION Dr. Jordana Bell,
King's College London, UK
EpiBrain Dr. Yvonne Lamers,
The University of British Columbia, Canada
HEROS Dr. Valerie Grandjean,
Inserm, France
NutriPROGRAM Dr. Janine Felix,
Erasmus MC Rotterdam, The Netherlands
PREcisE Prof. Marjo-Riitta Jarvelin,
Imperial College London, UK
More Information

Research Framework

Contact call Secretariat: ZonMw (NL),

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This project has received funding from the European Union’s
H2020 Research and Innovation Programme under grant agreement n.696300

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