ERA-HDHL (2018) - Nutrition and Epigenome
Nutrition & the Epigenome
In February 2018, the JPI HDHL launched the call: "Nutrition & the Epigenome" under the umbrella of ERA-HDHL. The 13 funded projects stared the first half of 2019 for a period of three years.
Background
A more complete understanding of the relationships between nutrition and health is central to deliver the vision of the JPI HDHL. However, even with modern genomics research and current dietary assessment methods, it is challenging to identify the key mechanisms by which diet influences health, and to establish causal relationships and predict outcomes. Investigating the fine regulation of genes, epigenetics, could provide the missing link. Research in this area is expected to provide insights that allow the development and scientific substantiation of intervention strategies for sustaining good health through all life stages and treating nutrition-related diseases.
Aim of the call
The aim of this call is to support transnational, collaborative research projects that gain a better understanding of the diet- epigenome relationships and their effect on human health. Proposals should focus on the diet and epigenome, and cover one of the following areas:
- Establishing cause-and-effect relationships between diet and epigenome and metabolic health including molecular and cellular mechanisms, its reversibility and long-term effects where feasibile;
- Identifying risk factors and early stage epigenetic changes involved in the development of metabolic diseases;
- Epigenetic effects across the lifespan and inter (and potentially trans) generational epigenetic effects;
- Investigation of modifiable factors (diet, the combined effect of diet and phyiscal activity, microbiota, etc.) that could be involved in epigenetic regulation at critical stages of life;
- The effect of diet and nutritional status on the intra-uterine environment and its subsequent effect on the fetal epigenome and later health of the child.
Participating countries
| Country | Funding Organisation | Short name |
|---|---|---|
| Canada | Canadian Institutes of Health Research | CIHR |
| Czech Republic | Ministry of Education, Youth and Sports | MEYS |
| France | French National Research Agency | ANR |
| Germany | Federal Ministry of Education and Research, represented by the Project Management Agency in the German Aerospace Center | BMBF Represented by DLR |
| Ireland * | Health Research Board | HRB |
| Israel * | Ministry of Science, Technology and Space | MoST |
| Latvia * | Ministry of Education and Science | IZM |
| The Netherlands | The Netherlands Organisation for Health Research and Development | ZonMw |
| Poland * | The National Centre for Research and Development | NCBR |
| Spain | National Institute of Health Carlos III | ISCIII |
| Spain | Research State Agency (Ministry of Economy, Industry and Competitiveness) | AEI (MINECO) |
| UK | Medical Research Council Biotechnology and Biological Sciences Research Council | MRC BBSRC |
* Did not fund research projects in this call
Funded projects
| Project | Coordinator |
|---|---|
| DIFAMEM | Dr. Maria Jose Torres, Regional University Hospital of Malaga, Spain |
| DIMENSION | Dr. Jordana Bell, King's College London, UK |
| EpiBrain | Dr. Yvonne Lamers, The University of British Columbia, Canada |
| HEROS | Dr. Valerie Grandjean, Inserm, France |
| NutriPROGRAM | Dr. Janine Felix, Erasmus MC Rotterdam, The Netherlands |
| PREcisE | Prof. Marjo-Riitta Jarvelin, Imperial College London, UK |
More Information
- Call text
- Quick guide for dissemination of the JPI HDHL research project results
- Factsheet ERA-HDHL Nutrition and the epigenome
Contact call Secretariat: ZonMw (NL), JPIHDHLprojects@zonmw.nl
