A Menu for Brain Responses Opposing Stress-Induced Alterations in Cognition

JPI HDHL JFA “Nutrition and Cognitive Function” (NutriCog)
A Menu for Brain Responses Opposing Stress-Induced Alterations in Cognition
AMBROSIAC
2016-04-01
2019-03-31
Prof. John F. Cryan
University College Cork (UCC)
Ireland

Consortium

Partner Organization Partner Country
Institut National de la Recherche Agronomique (INRA)France
German Center for Neurodegenerative Diseases (DZNE)Germany
University of Florence (UNIFI)Italy
University of Maastricht (NUTRIM)The Netherlands
King’s College London (KCL)United Kingdom

1. Overall project description


1.1 Summary

The aged brain is particularly vulnerable to stress-induced cognitive decline and will benefit tremendously from mechanistically-oriented dietary interventions to attenuate such cognitive impairment and to provide a general boost to brain health. Moreover, cognitive decline is increasingly present in the ageing population, who are living with chronic diseases and subjected to elevated levels of psychological stress, which are both huge challenges for the EU economy and society.


AMBROSIAC (A Menu for Brain Responses Opposing Stress-Induced Alterations in Cognition) investigates the influence of nutrition on stress-induced cognitive deficits in memory and executive functioning from adulthood to old age; and the impact of a nutritional intervention on cognitive ability, stress vulnerability and stress perception. It further interrogates the molecular mechanisms by which targeted nutritional interventions can improve stress-induced vulnerabilities in cognition in preclinical models.


Within the AMBROSIAC project we have determined that individuals on a non-obesogenic diet had lower levels of systemic inflammatory markers, and performed better in cognitive performance assessments following exposure to an acute stressor. Furthermore, supplementation of normal diet with vitamin A and an Ω-3 fatty acid-rich supplement docosahexanoic acid (DHA) improves working memory in aged individuals with elevated levels of the stress marker cortisol. Interrogating these phenomena using in vitro and preclinical modalities, we determined that short-chain fatty acids, Ω-3 fatty acid-rich and DHA-rich supplementation have anti-inflammatory properties; and can reverse stress-induced deficits in behaviour and cognitive performance. These beneficial effects were not observed in an animal model that was genetically bred to lack the ability to produce histamine. The beneficial effects of these dietary supplements on cognitive behaviour, stress and weight suppression were associated with changes in specific genera of bacteria within the gut. Further evidence for a role of gut bacteria in healthy ageing, stress and cognitive performance is provided by findings that prebiotics (dietary fibres) reduced neuroinflammation in ageing animals, and that a transfer of microbes belonging to young animals into aged animals reduced inflammatory markers in ageing animals.


These findings may impact on nutritional information for specific diets as a modulator of the microbiome to act as a prophylactic in improving healthy ageing (reducing stress, and maintaining cognitive performance), specifically in elderly individuals with elevated cortisol levels. Ultimately, these data may help to significantly transform healthcare strategies and policies, and lead to innovative, evidence-based approaches from the food industry which will notably improve dietary habits among consumers.


1.2 Highlights

Within the AMBROSIAC project we have determined that individuals on a non-obesogenic diet had lower levels of systemic inflammatory markers, and performed better in cognitive performance assessments following exposure to an acute stressor. Furthermore, supplementation of normal diet with vitamin A and an Ω-3 fatty acid-rich supplement docosahexanoic acid (DHA) improves working memory in aged individuals with elevated levels of the stress marker cortisol. Interrogating these phenomena using in vitro and preclinical modalities, we determined that short-chain fatty acids, Ω-3 fatty acid-rich and DHA-rich supplementation have anti-inflammatory properties; and can reverse stress-induced deficits in behaviour and cognitive performance. These beneficial effects were not observed in an animal model that was genetically bred to lack the ability to produce histamine. The beneficial effects of these dietary supplements on cognitive behaviour, stress and weight suppression were associated with changes in specific genera of bacteria within the gut. Further evidence for a role of gut bacteria in healthy ageing, stress and cognitive performance is provided by findings that prebiotics (dietary fibres) reduced neuroinflammation in ageing animals, and that a transfer of microbes belonging to young animals into aged animals reduced inflammatory markers in ageing animals.


These findings may impact on nutritional information for specific diets as a modulator of the microbiome to act as a prophylactic in improving healthy ageing (reducing stress, and maintaining cognitive performance), specifically in elderly individuals with elevated cortisol levels.


4. Impact


4.1 List of publications

AuthorsTitleYear, Issue, PPDoiPdf
M.G. Di Benedetto, C. Bottanelli, A. Cattaneo, C.M. Pariante, A. Borsini. KCLNutritional and immunological factors in breast milk: a role in the intergenerational transmission from maternal psychopathology to child development. 10.1016/j.bbi.2019.05.032
J. Giacobbe, B. Benoiton, P. Zunszain, C. M. Pariante, A. Borsini. The anti-inflammatory role of omega-3 polyunsaturated fatty acids metabolites resolvins, protectins and maresins in pre-clinical models of psychiatric, neurodegenerative and neurological disorders. org/10.3389/fpsyt.2020.00122
Giacobbe J., Benoiton B., Pariante C.M., Zunszain P., Borsini A. The role of resolvins, protectins and maresins in cognitive dysfunction and depressive disorders: Inflammation as a possible mechanism. https://doi.org/10.3389/fpsyt.2020.00122
van Beers M, Janssen DJA, Gosker HR, Schols AMWJ. Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions. doi: 10.1080/17476348.2018.1533405.
van Beers M, Rutten-van Mölken MPMH, van de Bool C, Boland M, Kremers SPJ, Franssen FME, van Helvoort A, Gosker HR, Wouters EF, Schols AMWJ. Clinical outcome and cost-effectiveness of a 1-year nutritional intervention programme in COPD patients with low muscle mass: The randomized controlled NUTRAIN trial. doi: 10.1016/j.clnu.2019.03.001.
M. Boehme, M. van de Wouw, K. van Sandhu, K. Lyons, F. Fouhy, L. Olavarria Ramirez, L. van Leuven, A. Golubeva, K. A. Scott, C. Stanton, T. G. Dinan, H.Schellekens, J. F. Cryan. Targeting the gut microbiome to reverse microglia activation and stress-induced immune priming in ageing. https://doi.org/10.1016/j.euroneuro.2017.12.038
Beijers RJ, Gosker HR, Sanders KJ, de Theije C, Kelders M, Clarke G, Cryan JF, van den Borst B, Schols AM. Resveratrol and metabolic health in COPD: A proof-of-concept randomized controlled trial. doi: 10.1016/j.clnu.2020.01.002
Gosker HR, Clarke G, de Theije CC, Cryan JF, Schols AMWJ. Impaired Skeletal Muscle Kynurenine Metabolism in Patients with Chronic Obstructive Pulmonary Disease. 10.3390/jcm8070915.
J.F. Cryan, K.J. O'Riordan, C.S.M. Cowan, K.V. Sandhu, T.F.S. Bastiaanssen, M. Boehme, M.G. Codagnone, S. Cussotto, C. Fulling, A.V. Golubeva, K.E. Guzzetta, M. Jaggar, C.M. Long-Smith, J.M. Lyte, J.A. Martin, A. Molinero-Perez, G.M. Moloney, E. Morelli, E. Morillas, R. O'Connor, J. Pereira, V.L. Peterson, K. Rea, N.L. Ritz, E. Sherwin, S. Spichak, E.M. Teichman, M. van de Wouw, A.P. Ventura-Silva, S.E. Wallace-Fitzsimons, N. Hyland, G. Clarke, T.G. Dinan. The Microbiota-Gut-Brain Axis. 10.1152/physrev.00018.2018.
M. Boehme, M. van de Wouw, T.F.S. Bastiaanssen, L. Olavarria-Ramirez, K. Lyons, F. Fouhy, A.V. Golubeva, G.M. Moloney, K.V. Sandhu, K.A. Scott, C. Minuto, G. Clarke, C. Stanton, T.G. Dinan, H. Schellekens, J.F. Cryan. Mid-Life Microbiota Crises: Middle age is Associated with Pervasive Neuroimmune Alterations that are Reversed by Targeting the Gut Microbiome in Male Mice. 10.1038/s41380-019-0425-1.
A. Gururajan, M. van de Wouw, M. Boehme, T.M. Becker, R. O’Connor, T.F.S. Bastiaanssen, G.M. Moloney, J.M. Lyte, A.P. Ventura-Silva, B. Merckx, T.G. Dinan, J.F. Cryan. Resilience to Social Defeat Stress Is Associated with Alterations in Specific Neuroendocrine and Immune Responses. 10.1016/j.bbi.2019.05.004.
J.F. Cryan, M. Boehme, T.G. Dinan. Is the Fountain of Youth in the Gut Microbiome? 10.1113/JP277784.
M. van de Wouw, M. Boehme, J. Lyte, N. Wiley, C. Strain, O. O'Sullivan, G. Clarke, T. G. Dinan, J. F. Cryan. Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations. 10.1113/JP276431.
G. Provensi, S.D. Schmidt, M. Boehme, T.F.S. Bastiaanssen, B. Rani, A. Costa, K. Busca, F. Fouhy, C. Strain, C. Stanton, P. Blandina, I. Izquierdo, J.F. Cryan, M.B. Passani. Preventing Adolescent Stress-induced Cognitive and Microbiome Changes by Diet. 10.1073/pnas.1820832116.
Cussotto S, Delgado I, Anesi A, Dexpert S, Aubert A, Beau C,Forestier D, Ledaguenel P, Magne E,Mattivi F and Capuron L. Tryptophan Metabolic Pathways Are Altered in Obesity and Are Associated With Systemic Inflammation. 10.3389/fimmu.2020.00557
Di Paola M, Bonechi E, Provensi G, Costa A, Clarke G, Ballerini C, De Filippo C, Passani MB. Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer's patches of mice. 10.1038/s41598-018-32925-x.
Provensi G, Costa A, Izquierdo I, Blandina P, Passani MB. Brain histamine modulates recognition memory: possible implications in major cognitive disorders. 10.1111/bph.14478.

4.2 Presentation of the project

Target groupAuthorsMeans of communicationHyperlinkPdf
ScientistsS. E. Oumohand, N. Merten, M. M. Bönniger, D. D. Ward, C. Kirschbaum, M. M. B. Breteler. Differential associations of chronic perceived stress and hair cortisol levels with cognitive functioning across adulthood, 13th Annual Meeting of the German Society of Epidemiology (DGEpi), Bremen, Germany, September 2018Oral Communication
ScientistsS. E. Oumohand, N. Merten, M. M. Bönniger, D. D. Ward, C. Kirschbaum, M. M. B. Breteler. Chronic perceived stress and hair cortisol differentially relate to cognitive functioning across adulthood, 48th Annual Meeting of the International Society of Psychoneuroendocrinology (ISPNE), Irvine, California, USA, September 2018Poster communication
ScientistsM. M. B. Breteler, Flash presentation on the Rhineland Study, ILSI Symposium on Nutrition for the Ageing Brain, Madrid, Spain, August 2018Oral Communication
ScientistsM. M. B. Breteler, Planning new studies on brain aging: The Rhineland Study, 4th Neurepiomics Summer School, Arachon, France, September 2018Oral Communication
ScientistsM. M. B. Breteler, Towards healthy brain aging and disease prevention: the Rhineland Study, Meeting of the German Association for Psychiatry, Psychotherapy and Psycho-somatics (DGPPN), Berlin, Germany, November 2018Oral Communication
General PublicM. M. B. Breteler, Gehirn und Gesunheit – Was wir schon wissen und warum wir die Rhinland Studie trotzdem brauchen, Bonn, Germany, November 2018Oral Communication
ScientistsDelgado I., Dexpert S., Sauvant J., Boehme M., Cryan J.F., Capuron, L. Impact of dietary habits on stress-induced cognitive alterations in healthy. Neurofrance 2019. Bordeaux, France, May 2019.Poster Presentation
ScientistsDelgado I., Dexpert S., Sauvant J., Capuron L. Impact of dietary habits on stress-induced cognitive alterations in healthy adults: preliminary results. JPI meeting. Firenze, Italy, May 2018. Oral Communication
ScientistsDelgado I., Dexpert S., Sauvant J., Capuron L. Impact of dietary habits on stress-induced cognitive alterations in healthy adults. 8th NutriNeuro's annual meeting. Bordeaux, France, February 2019.Oral Communication
General PublicDelgado I., Dexpert S., Le STRESS influence-t-il vos capacités cognitives ? Brain’s Week 2019. Bordeaux, France, March 2019Oral Communication
ScientistsDelgado I., Dexpert S., Sauvant J., Capuron L. Impact of dietary habits on stress-induced cognitive alterations in healthy adults. 12th Nutrition and Neurosciences meeting. Bordeaux, France, April 2019.Oral Communication
ScientistsDelgado I., Dexpert S., Sauvant J., Capuron L. Impact of unhealthy dietary habits on stress-induced cognitive alterations in normal volunteers. Bordeaux, France, February 2020Oral Communication
ScientistsCapuron L. Nutritional habits, obesity and neuropsychiatric symptoms. International Society for Nutritional Psychiatry Research, London, UK, October 2019.Oral Communication
ScientistsBorsini, A., Pariante, C.M., Zunszain, P.A. Rescue of IL-1β−induced reduction of human neurogenesis by antidepressants and omega-3 fatty acids. XXII Congresso Nazionale, Società Italiana di Psicopatologia (SOPSI), 21-24 February 2018, Rome, Italy. Oral communication
ScientistsBorsini, A., Pariante, C. M., Zunszain, P.A. Rescue of cytokines-induced reduction of human neurogenesis and increase in apoptosis by omega-3 fatty acids. 25th Annual Psychoneuroimmunology Research Society (PNIRS) Scientific Meeting, 6-9 June 2018, Miami, USA.Poster Presentation
ScientistsBorsini, A., Pariante, C.M., Zunszain, P.A. Rescue of cytokines-induced reduction of human neurogenesis and increase in apoptosis by omega-3 fatty acids. British Association for Psycopharmacology, Summer Meeting 22-25 July 2018, London, UK.Poster Presentation
ScientistsBorsini, A., Nicolaou, A., Camacho-Munoz, M. D., Su, K., Zunszain, P.A.. Pariante, C.M. The role of omega-3 fatty acids and their metabolites in preventing cytokines-induced reduction of human hippocampal neuro-genesis. 26th Annual Psychoneuroimmuno-logy Research Society (PNIRS) Scientific Meeting, 4-8 June 2019, Berlin, GermanyPoster Presentation
ScientistsBorsini, A., Nicolaou, A., Camacho-Munoz, M. D., Su, K., Zunszain, P.A.. Pariante, C.M. The role of omega-3 fatty acids and their metabolites in preventing cytokines-induced reduction of human hippocampal neurogenesis. British Association for Psycopharmacology, Summer Meeting 14-17 July 2019, Manchester, UK.Poster Presentation
ScientistsBorsini, A., Nicolaou, A., Camacho-Munoz, M. D., Su, K., Zunszain, P.A.. Pariante, C.M. The role of omega-3 fatty acids and their metabolites in preventing cytokines-induced reduction of human hippocampal neuro-genesis. 50th Congress of Psycho-neuro-endocrinology 29-31 August 2019, Milan, ItalyOral Presentation
ScientistsBorsini, A., Nicolaou, A., Camacho-Munoz, M. D., Su, K., Zunszain, P.A.. Pariante, C.M. The role of omega-3 fatty acids and their metabolites in preventing cytokines-induced reduction of human hippocampal neuro-genesis. 6th Congress of Asian College of Neuropsychopharmacology 11-13 October 2019, Fukuoka, Japan.Oral Presentations
ScientistsBorsini, A., Pariante, C. M., Zunszain, P.A. The role of omega-3 fatty acids and their metabolites in preventing cytokines-induced reduction of human hippocampal neurogenesis. British Association for Psycopharmacology, Summer Meeting 19-22 July 2020, London, UK.Oral Presentations
ScientistsBorsini, A., Pariante, C. M., Zunszain, P.A. Rescue of interferon (IFN)-alpha-induced reduction of human neurogenesis and increase in apoptosis by omega-3 fatty acids. 27th Annual Psychoneuroimmunology Research Society (PNIRS) Scientific Meeting 3-6 June 2020, Los Angeles, USA.Oral Presentation
ScientistsBorsini, A., Pariante, C. M., Zunszain, P.A. Rescue of interferon (IFN)-alpha-induced reduction of human neurogenesis and increase in apoptosis by omega-3 fatty acids. Society of Biological Psychiatry 75th Annual Meeting 30-2 May 2020, New York, USA.Oral Presentations
ScientistsBorsini, A., Pariante, C. M., Zunszain, P.A. The role of omega-3 fatty acids and their metabolites in preventing cytokines-induced reduction of human hippocampal neurogenesis. International Society for Nutritional Psychiatry 20-22 October 2019, London, UK.Oral Presentations
ScientistsJ. F. Cryan. A Gut Feeling About Happiness. The World Government Summit. Dubai, United Arab Emirates, 2018.Oral Communication
General PublicM. Boehme, K.E. Guzzetta. Healthy Diet, Healthy Gut, Healthy Us. Sauerkrautathon 2018, Wells Food Festival, Wells/UK.Oral Communication
General PublicM. Boehme, K.E. Guzzetta, T.G. Dinan, J.F. Cryan. Sauerkraut & Fermented Food meets Gut microbiota: Eat your way towards better (brain) health. Fermented Food Convention, Wells/UK. October 2018.Oral Communication
ScientistsM. Boehme, K.E. Guzzetta, H. Schellekens, T.G. Dinan, J.F. Cryan. Microbiome, Neuro-immunity and Aging: Finding the Fountain of (Brain) Youth in our Gut Microbes? 5th JPI-NutriCog Ambrosiac Consortium Meeting, Bordeaux/France.Oral Communication
ScientistsM. Boehme, J.F. Cryan. Research Impact, Legacy and Adoption- case studies in research communications – Insights from the Ambrosiac consortium. 5th JPI-HDHL conference, Brussels/Belgium. February 2019.Oral Communication
ScientistsM. Boehme, H. Schellekens, T.G. Dinan, J.F. Cryan. Microbiome, Neuroimmunity and Aging: Finding the Fountain of (Brain) Youth in our Gut Microbes? APC Microbiome Ireland Forum, Cork/Ireland. November 2018Oral Communication
ScientistsM. Boehme, T.G. Dinan, H. Schellekens, J.F. Cryan. A gut feeling about ageing: feeding the gut microbiota towards better (brain) health. Donders Discussion 2018, Nijmegen/Netherlands. October 2018.Oral Communication
ScientistsM. Boehme, J.F. Cryan. A gut feeling about the brain: role of microbiome in neuro-development and behavior, Neurosciences postgraduate teaching meeting, Department of Clinical Neurosciences, Cambridge, UK, March 2018.Oral Communication
ScientistsM. Boehme, H. Schellekens, T.G. Dinan, J.F. Cryan . A gut feeling about ageing: the impact of diet on behavior and brain health across life, Dutch Neuroscience Meeting, Lunteren, Netherlands, June 2018.Oral Communication
ScientistsJ. F. Cryan. New Advances: Diet and Microbiome, ILSI, Bermuda, January 2018.Oral Communication
ScientistsJ.F. Cryan. A Gut Feeling About the Brain: The Microbiome Modulates Behaviour Across the Lifespan. Invited Seminar. University of Tennessee UTHSC/USA. February 2018.Oral Communication
ScientistsJ.F. Cryan. Stress and the brain-gut axis. FNM 2018. Amsterdam/Netherlands. September 2018.Oral Communication
ScientistsJ.F. Cryan. Microbiome-gut-brain axis: A key regulator of stress (Resilience). 4th International Symposium on Resilience Research. Mainz/Germany. September 2018Oral Communication
ScientistsJ.F. Cryan. The diet-microbiome-gut-brain axis to support brain health. ECNP. Barcelona /Spain. October 2018. Oral Presentation
ScientistsJ.F. Cryan. The impact of microbiome on brain functions across the lifespan. Workshop on Microbiome & Gut Brain Axis. Norwich/UK. November 2018.Oral Presentation
ScientistsJ.F. Cryan. A Gut (Microbiome) Feeling About Stress. The 2nd Munich Winter Conference on Stress. Munich/Germany. March 2019Oral Presentation
ScientistsJ.F. Cryan. Gut Feelings: The Microbiome as a Key Regulator of Brain and Behaviour Across the Lifespan. Helsinki Institute of Life Science. Helsinki/Finland. April 2019Oral Presentation
ScientistsJ.F. Cryan. Could the gut hold the secret for healthy ageing? British Neuroscience Association. Invited seminar. Dublin/Ireland. April 2019.Oral Presentation
General PublicJ.F. Cryan. Feed Your #Microbes - Nurture Your Mind - TEDx talkOral Presentation
ScientistsM. Boehme, M. van de Wouw, K. van Sandhu, K. Lyons, F. Fouhy, L. Olavarria Ramirez, L. van Leuven, A. Golubeva, K.A. Scott, C. Stanton, T.G. Dinan, H. Schellekens, J.F. Cryan. Targeting the gut microbiome to reverse microglia activation and stress-induced immune priming in ageing. ECNP Workshop on Neuropsycho-pharmacology for Junior Scientists, Nice, France, March 2018.Poster Presentation
ScientistsM. Boehme, M. van de Wouw, K. van Sandhu, K. Lyons, F. Fouhy, L. Olavarria Ramirez, L. van Leuven, A. Golubeva, K.A. Scott, C. Stanton, T.G. Dinan, H. Schellekens, J.F. Cryan. Targeting the gut microbiome to reverse microglia activation and stress-induced immune priming in ageing. EMBO Microglia Workshop 2018, Heidelberg/Germany, March 2018.Poster Presentation
ScientistsA. Gururajan, M. Boehme, M. van de Wouw, T. Becker, R. O’Connor, T. F. S. Bastiaanssen, G. M. Moloney, J. M. Lyte, A. P. Ventura-Silva, B. Merckx, T. G. Dinan, J. F. Cryan. Decoding the Central, Endocrine & Immune Signatures of Stress Resilience in Mice. 27th Annual Meeting of the International Behavioral Neuroscience Society (IBNS), Boca Raton/USA, July 2018.Poster Presentation
ScientistsM. van de Wouw, M. Boehme, J. Lyte, N. Wiley, C. Strain, O. O'Sullivan, G. Clarke, T. G. Dinan, J. F. Cryan. Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations. FNM 2018 - 3rd Meeting of the Federation of Neurogastroenterology and Motility, Amsterdam/The Netherlands, August 2018.Poster Presentation
ScientistsM. Boehme, M. van de Wouw, L. Olavarria-Ramirez, K. Lyons, F. Fouhy, A. Golubeva, G. Moloney, K.V. Sandhu, K.A. Scott, G. Clarke, C. Stanton, T.G. Dinan, H. Schellekens, J. F. Cryan. Microbiome and Aging: Dietary targeting of the gut microbiome reversed age-associated neuroimmune alterations. Jena Aging Meeting, Jena/Germany, September 2018.Poster Presentation
ScientistsVan de Wouw M, Walsh AM, Crispie F, van Leuven L, Lyte JL, Boehme M, Clarke G, Cotter PD, Dinan TG, Cryan JF. Towards a Rational Targeting of the Microbiome with the Fermented Milk Drink Kefir to Modulate Host Behaviour. 5th New Horizons School of Medicine Research Conference (UCC), Cork/Ireland, December 2018.Poster Presentation
ScientistsM. Boehme, K.E. Guzzetta, M. van de Wouw, K.A. Scott, M. Ida, L. Olavarria-Ramirez, G.M. Moloney, C. Minuto, A.V. Golubeva, E. Morillas, C.S.M. Cowan, N. Ritz, G. Clarke, O. O’Leary, H. Schellekens, T.G. Dinan, J.F. Cryan. Microbiome, Neuro-immunity and Aging - Finding the Fountain of (Brain) Youth in our Gut Microbes? 2nd Mind, Mood and Microbes, Amsterdam/Netherlands, January 2019.Poster Presentation
General PublicM. Boehme, T.G. Dinan, H. Schellekens, J.F. Cryan. APC Scientists Target Gut Microbes To Reverse The Effects Of Ageing In Middle Age. http://apc.ucc.ie/fibre-ferrari-brain/ (in relation to Boehme et al. 2019, Molecular Psychiatry).Press Release
ScientistsAlessia Costa et al., Histamine neurotrans-mission as a cognitive gateway integrating peripheral signals. World Histamine Symposium. Kobe (Japan) 2018.Oral Communication
ScientistsSchmidt SD, Costa A, Rani B, Izquierdo I, Blandina P, Passani MB, Provensi G. An Omega-3 PUFA/Vitamin A enriched diet to prevent cognitive deficits induced by the social instability stress. 11th FENS Forum of Neurosciences, FENS 2018. Programme F-049, Berlin, Germany, 2018.Poster Presentation
ScientistsRani B, Provensi G, Schmidt SD, Blandina P, Passani MB, Costa A. Interaction between central histaminergic system and omega-3 fatty acid/vitamin A enriched diet in cognitive decline induced by chronic social defeat stress. 11th FENS Forum of Neurosciences, FENS 2018. Programme C-154, Berlin, Germany, 2018.Poster Presentation
ScientistsRani B, et al. Interaction between central histaminergic system and oleoylethanolamide in cognitive deficits induced by chronic social defeat stress. National Meeting of PhD Students in Neurosciences - New perspectives in Neuroscience: Research Results of Young Italian Neuroscientists Programme, p. 20, Naples, Italy, 2018.Oral Communication
ScientistsRani B, et al. Procognitive effects of an omega-3 Fatty Acid-Vitamin A enriched diet or of Oleoylethanolamide on the cognitive impairment induced by chronic stress. Role of the brain histaminergic system. XXI SIF Seminar On Pharmacology For Phd Students, Fellows, Post Doc And Specialist Trainees, Programme p.18, Bresso, Italy, 2018.Oral Communication
ScientistsProvensi G, et al. Preventing Adolescent Stress-induced Cognitive and Microbiome Changes by Omega 3-PUFA/Vitamin A Diet Enrichment. Convegno Monotematico della Società Italiana di Farmacologia “Le BasiFarmacologiche dei Nutraceutici”. Programma, p. 85. Naples, Italy, 2019.Oral Communication
ScientistsPassani MB “Nutritional supplementation prevents neurobehavioral deleterious effects of chronic stress during adolescence” 48th Meeting of the European Brain and Behaviour Society Prague (Czech Republic) 21st-24th September 2019 Oral Communication
ScientistsPassani MB What’s histamine got to do with memory, stress and appetite? 48th Meeting of the European Histamine Society. Krakow (Pl) 15th-18th May 2019.Oral Communication
ScientistsRani B et al., Diet prevents social defeat stress-induced cognitive and neurophysiologic modifications by activating the central histamine system. 48th Meeting of the European Histamine Society. Krakow (Pl) 15th-18th May 2019.Oral Communication
ScientistsRani B et al., Oleoylethanolamide requires brain histamine to prevent cognitive impairments induced by chronic stress. 48th Meeting of the European Histamine Society. Krakow (Pl) 15th-18th May 2019.Poster Presentation
ScientistsCosta A. et al., Omega3 PUFA/Vitamin A enriched diet confers resilience to stress-induced cognitive and neurophysiological modifications. Role of the brain histaminergic system. 39° Congress of the Italian Pharmacological Society, Florence (I) 20th-23rd Novembere 2019Oral Communication
ScientistsProvensi G. From Gut to Brain: a Pas de Deux between the satiety factor oleoylethanolamide and the central histaminergic system. Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasile. 20th September 2019Oral Communication
ScientistsProvensi et al., Preventing immediate and long-term adolescent stress-induced cognitive deficits and gut microbiota alterations by Omega-3 polyunsaturated fatty acids/ Vitamin A diet enrichment. 39° Congress of the Italian Pharmacological Society, Florence (I) 20th-23rd Novembere 2019Oral Communication
ScientistsPassani MB “Nutritional supplementation prevents neurobehavioral deleterious effects of chronic stress during adolescence” 48th Meeting of the European Brain and Behaviour Society Prague (Czech Republic) 21st-24th September 2019 Oral Communication
ScientistsPassani MB What’s histamine got to do with memory, stress and appetite? 48th Meeting of the European Histamine Society. Krakow (Pl) 15th-18th May 2019.Oral Communication
ScientistsRani B et al., Diet prevents social defeat stress-induced cognitive and neurophysiologic modifications by activating the central histamine system. 48th Meeting of the European Histamine Society. Krakow (Pl) 15th-18th May 2019.Oral Communication
ScientistsRani B et al., Oleoylethanolamide requires brain histamine to prevent cognitive impairments induced by chronic stress. 48th Meeting of the European Histamine Society. Krakow (Pl) 15th-18th May 2019Poster Presentation
ScientistsCosta A. et al., Omega3 PUFA/Vitamin A enriched diet confers resilience to stress-induced cognitive and neurophysiological modifications. Role of the brain histaminergic system. 39° Congress of the Italian Pharmacological Society, Florence (I) 20th-23rd Novembere 2019Oral Communication
ScientistsProvensi G. From Gut to Brain: a Pas de Deux between the satiety factor oleoylethanolamide and the central histaminergic system. Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasile. 20th September 2019Oral Communication
ScientistsProvensi et al., Preventing immediate and long-term adolescent stress-induced cognitive deficits and gut microbiota alterations by Omega-3 polyunsaturated fatty acids/ Vitamin A diet enrichment. 39° Congress of the Italian Pharmacological Society, Florence (I) 20th-23rd Novembere 2019Oral Communication
ScientistsM van Beers, C van de Bool, A van Helvoort, S Kremers, F Franssen, E Wouters, A Schols. OR13: Long-term efficacy of a nutritional intervention strategy to optimize and maintain efficacy of pulmonary rehabilitation in COPD: the Nutrain trial. Clinical Nutrition 2017 36, Supplement 1: S6; ESPEN The Hague, 9-12 Sept 2017Poster Presentation
ScientistsM van Beers, M Rutten-Van Molken, C van de Bool, M Boland, S Kremers, F Franssen, A van Helvoort, H Gosker, E Wouters, A Schols. Clinical outcome and cost-effectiveness of 1-year nutritional intervention program in COPD. European Respiratory Journal 2018 52: Supplement 62, PA723; ERS Paris, 15-19 Sept 2018Poster Presentation
ScientistsM van Beers, D Janssen, F Cleutjens, H Gosker, F Franssen, E Wouters, A Schols. The impact of sarcopenia and metabolic syndrome on cognitive performance in patients with COPD. J Cachexia, Sarcopenia and Muscle 2018 9, 1136-1137; Society on Sarcopenia, Cachexia and Wasting Disorders congress Maastricht, 7-9 Dec 2018Poster Presentation
Scientists/CliniciansRosanne Beijers, Harry R. Gosker, Karin J.C. Sanders, Chiel De Theije, Marco Kelders, Gerard Clarke, John F. Cryan, Bram Van Den Borst, Annemie M.W.J. Schols. The effect of resveratrol on muscle and fat metabolic health in COPD. European Respiratory Journal 2019 54: PA2340; ERS Paris, 15-19 sept 2018Poster Presentation
Scientists/CliniciansHarry R. Gosker, Gerard Clarke, John F. Cryan, Annemie M. Schols Impaired skeletal muscle kynurenine metabolism in patients with COPD. European Respiratory Journal 2018 52: PA940; ERS Paris, 15-19 sept 2018Poster Presentation
Scientists/CliniciansM van Beers, M Rutten-Van Molken, C van de Bool, M Boland, S Kremers, F Franssen, E Wouters, A van Helvoort, A Schols. Clinical outcome and cost-effectiveness of nutritional rehabilitation in COPD patients with low muscle mass; NUTRIM symposium, 22 Nov 2017Poster Presentation
Scientists/CliniciansMartijn van Beers, Daisy Janssen, Fiona Cleutjens, Harry Gosker, Frits Franssen, Emiel Wouters, Annemie Schols. The relationship of sarcopenia and metabolic syndrome with cognitive performance in patients with COPD; NUTRIM symposium, 21 Nov 2018Poster Presentation
Scientists/CliniciansMartijn van Beers, Jessie J. M. Meis, Coby van de Bool, Annemie M. W. J. Schols, Stef P. J. Kremers. Motivational regulations and lifestyle in patients with COPD and low muscle mass before and after pulmonary rehabilitation; NUTRIM symposium, 27 Nov 2019Poster Presentation

4.3 List of submitted patents and other outputs

Patent licencePartners involvedYearInternational eu or national patentCommentPdf

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