Tailored Carbohydrate Quality for Personalized Weight Management and Metabolic Health

Impact of Diet, Food Components and Food Processing on Body Weight Regulation and Overweight Related Metabolic Diseases (METADIS 2019)
Tailored Carbohydrate Quality for Personalized Weight Management and Metabolic Health
Rikard Landberg
Chalmers University of Technology


Partner Organization Partner Country
Università degli Studi di TorinoItaly
University of BarcelonaSpain
University of HohenheimGermany
Bellvitge Biomedical Research Institute (IDIBELL) Spain
SLU-Swedish University of Agricultural SciencesSweden

1. Overall project description

1.1 Summary

This project investigates the role of carbohydrate quality (CQ) on weight management, appetite and cardiometabolic health in humans as well as underlying mechanisms by which CQ affects consumers. It will also promote career development and mobility of Early Career Scientists (ECS) to foster the new generation of scientists in food and health. Experimental models, clinical approaches and OMICs are used in a multidisciplinary setting. Results will be transferred to industry and disseminated to the scientific community and general public. We take advantage of the data and samples from 12-wk weight-loss study conducted in collaboration with Agrifood industry, investigating weight- and fat-loss after a high fibre vs refined fibre diet. Satiety and gut microbiota are currently evaluated as determinants of weight-loss and we will analyze cardiometabolic risk factors and molecular phenotypes associated with weight-loss and cardiometabolic risk profiles using metabolomics and proteomics. Molecular signatures of successful weight-loss and low cardiometabolic risk, will be validated in a prospective cohort of women (n=5022, data already available), and in a corresponding cohort in men (n=6000, data will be available during 2020). Moreover, a rat model will be used to study the potential adverse effects of refined carbohydrates at organ/tissue level and the potential beneficial effects of supplementation with fermentable dietary fibre. Particular focus will be put on metabolic inflammation and effects mediated through AGEs, the gut barrier and microbiota. We will compare preclinical metabolite profiles to metabolic signatures of the human studies to elucidate the molecular alterations associated with weight-loss and cardiometabolic risk in humans.
In summary, we will exploit (i) metabolomics to discover biomarker panels that can predict tailored advice on high-fibre diets for successful weight-loss (personalized nutrition), (ii) mechanistic studies to identify molecular mechanisms evoked by carbohydrates and (iii) the relationship between perceived satiety and food structure.
Results are expected to translate into improved high-fibre foods tailored for optimal metabolic health and weight management for individuals or consumer groups.

1.2 Highlights


It is too early to communicate results at this stage.

It is too early to make any conclusions at this stage. The focus has been on data generation and study planning. It has been progressing smoothly despite COVID-19 and data is currently analysed.


The microstructure of in vitro digested wheat and rye products was very different, with a higher degree of disintegration on wheat products. This will be of relevance when combining with results of metabolomics analysis from the intervention studies.

4. Impact

4.1 List of publications

AuthorsTitleYear, Issue, PPPartners NumberDoiPdf
MhD Omar NA*, Dicksved J, Kruger J, Zamaratskaia G, Michaelssson K*, Wolk A*, Frank J*, Landberg R*: Effects of a diet rich in galactose or fructose, with or without fructooligosaccharides, on gut microbiota composition in ratsVolume65, Issue6 March 2021 32001133
Raffaella Mastrocola, Debora Collotta*, Giulia Gaudioso, Marie Le Berre, Alessia Sofia Cento, Gustavo Ferreira Alves* , Fausto Chiazza* , Roberta Verta , Ilaria Bertocchi, Friederike Manig, Michael Hellwig, Francesca Fava , Carlo Cifani , Manuela Aragno, Thomas Henle, Lokesh Joshi, Kieran Tuohy and Massimo Collino*Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation. 2020, 12(9):2497. 1doi: 10.3390/nu12092497

4.2 Presentation of the project

Target groupAuthorsMeans of communicationHyperlinkPdf
Scientists, industry and health care staffLandberg, Rikard. Metabolomics to guide personalized cereal food consumption - emerging results from human studies. HealthGrainForum Webinar on "Personalisation of Grain Consumption" September 16, 2020.Invited webinar presentation
Scientists, industryLandberg, Rikard. The role of grains in sustainable & personalized nutrition 4 health. HealthGrainForum autumn meeting, November 5-6Invited webinar presentation
ScientistsAnne K Eriksen , Carl Brunius , Mohsen Mazidi , Per M Hellström , Ulf Risérus , Kia N Iversen, Rikard Fristedt , Li Sun , Yi Huang, Natalja P Nørskov, Knud Erik B Knudsen , Cecilie Kyrø , Anja Olsen , Anne Tjønneland, Johan Dicksved, Rikard Landberg. Effects of whole-grain wheat, rye and lignan supplementation on cardio-metabolic risk factors in men with metabolic syndrome: a randomized crossover trial. Nordic Nutrition Conference, Helsinki 15-16 December 2020. Invited oral presentation at the conference (through zoom)
Industry and scientistIndustry and scientists Landberg, Rikard. Rye, gut microbiota and cardio-metabolic health. Symposium: Rye-The “wholy” grain for gut and brain, Nordic Nutrition Conference 15 December 2020Invited oral presentation at the symposium
IndustryCristina Andres-Lacueva, polyphenol and biomarkers assement, July 15th, 2020Invited oral, webinar, industrial training, online
Scientist , Open accessPol Castellano Ontology, FOBI, POMAInvited webinar
Scientist, Industry, health care staffTomas Meroño, Andrea Unión Caballero, Cristina Andrés-Lacueva. Importance of omics sciences in biotechnology. III Congress of Food science, Nutrition and Dietetics organized by the Spanish Academy of Nutrition and Dietetics. 23-27 November 2020.Invited webinar presentation at the symposium

4.3 List of submitted patents and other outputs

Patent licencePartners involvedYearInternational eu or national patentCommentPdf

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This project has received funding from the European Union’s
H2020 Research and Innovation Programme under grant agreement n.696300

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