CirculAting Bile Acids as biomarkers of metabolic health - Linking microbiotA, Diet and Health.

ERA-HDHL cofunded call “Biomarkers for Nutrition and Health” (BioNH 2016)
CirculAting Bile Acids as biomarkers of metabolic health - Linking microbiotA, Diet and Health.
CABALA_diet&health
2017-06-01
2021-05-31
Kieran Tuohy
Fondazione Edmund Mach
Italy

Consortium

Partner Organization Partner Country
University Of ReadingUnited kingdom
University College CorkIreland
University of InsubriaItaly

1. Overall project description


1.1 Summary

Bile acids (BA) through G protein-coupled bile acid receptor 1 (GPBAR1 or TGR5) and nuclear receptors like Farnesoid X receptor (FXR) regulate mammalian inflammation, and lipid, glucose, energy, and xenobiotic metabolism. The gut microbiota modulates the enterohepatic circulation of BA and microbially produced secondary BA appear to be more potent receptor agonists than primary BA, providing a mechanistic link between microbiome structure/function and regulation of host physiology. Evidence mainly from animal studies shows that dietary fibers and polyphenols and exercise can impact on BA metabolism. Similarly, certain bile salt hydrolysing (BSH) bacteria modulate circulating bile acid (CBA) profiles and strongly influence cholesterol uptake. However, human data confirming dietary modulation of CBA profiles and subsequent regulation of physiological homeostasis remains elusive. Using samples from the RoCAV cohort and existing randomised control trials (RCT), we correlated CBA profiles with Mediterranean (MED) diet adherence and measures of metabolic health. In a bespoke short-term RCT we measured the effect of Limosilactobacillus reuteri NCIMB 30242 (BSH positive probiotic), oats (prebiotics) and  Renetta Canada apples (polyphenol rich) on CBA and demonstrated that L. reuteri could increase host postprandial unconjugated and hydrophobic CBA profiles, and that oats and apples may modulate cardiovascular disease (CVD) risk markers in both chronic and acute settings. In a long term (18 month), large-scale (n=300) existing dietary and lifestyle intervention, we demonstrated how a polyphenol rich green-MED diet and exercise promotes metabolic health in prediabetics through modulation of the gut microbiota and CBA signalling (DIRECT-PLUS study). Finally, we  modelled BA profiles or metabotype with microbiome signatures and BA biotransformation potential using high-resolution metagenomics and established the molecular basis of BA regulation of immune and metabolic homeostasis by measuring the relative receptor activation potential of individual CBA and BA-metabotype profiles using novel pre-clinical human cell-based reporter systems. CABALA_diet&health has provided direct evidence in humans that CBA profiles influence CVD risk supporting their consideration as biomarkers of health, related to the microbiome and modulated by diet and exercise. We have also demonstrated in humans, that autholgous faecal microbiome transfer, after green-MED dietary intervention retards weight regain and maintains metabolic health. Moreover, we propose that global BA species diversity may be an indicator of health and bile acid convergence a function of disease, and additionally, that lowering total CBA concentrations may be a viable target for improving metabolic health at the population level.


1.2 Highlights


Diet-microbe-gut health dialogue centers on bile acid (BA) activation of signaling receptors in dictating both metabolic and health status.  Our work indicates global diversity as an indicator of health, bile acid convergence is a function of disease. In Cork Ireland, we have determined, through cellular systems, signaling and gene expression overlap along with independence of process between three bile acid receptors (FXR, VDR, TGR5), functionally and regionally.  Finally, bile acids are emulsifiers of lipid.  Our work has shown that lipids can act as a sequesterants of certain bile acids negating their signaling effects, at the level of gene expression and cell organelle fitness.


We have demonstrated, in a bespoke mixed chronic and acute postprandial challenge dietary intervention conducted in Reading UK, that functional foods specifically, oats (prebiotic), polyphenol rich apples (Renetta Canada apples) and a BSH positive probiotic, (Limosilactobacillus reuteri NCIMB 30242), can influence post prandial circulating BA (CBA) profiles on an individual basis but may mediate their respective health effects via different mechanisms, especially during the postprandial phase. Apples reduced fasting apoB, a marker of low-density lipoprotein cholesterol (an independent CVD risk factor), and both oats and apples influenced postprandial glycaemic control and triacylglycerol response.  L. reuteri had a significant effect on postprandial secondary CBA concentrations. 


From the RoCAV cohort study in Varese Italy, we confirmed that diet was associated with CBA profiles, which were in turn associated with metabolic health. Specifically, high levels of CBA were associated with unhealthy metabolic parameters, whereas high levels of the BA responsive hormone FGF-19 was confirmed to be associated with reduced HOMA index and waist-to-hip ratio. 


In the DIRECT-PLUS dietary intervention with a polyphenol enriched Mediterranean diet conducted at the Ben Gurion University of the Negev in Israel, 6 month weight loss could be directly attributed to dietary microbiota modulation. Moreover, total CBA concentrations positively correlated with metabolic disease risk factors and autochthonous faecal microbiome transplant (aFMT) after green-MED diet microbiome modulation retarded weight regain over an 8 month follow up and maintained metabolic health.  


Strong correlations between individual CBA species or ratios with individual bacterial taxa were rare within the datasets and not consistent between different studies. Correlations between CBA profiles and enterotype-like community structures were apparent but not conserved across different data-sets. Microbial BA metabolism may therefore be more correctly considered as a community activity, possibly with different taxa performing similar chemical conversions in different individuals. Shotgun and strain level analysis did not resolve CBA:taxa associations but revealed relatively low prevalence and abundance of BA metabolizing genes across samples, suggesting a gap in knowledge concerning annotation of microbial BA metabolising genes.


4. Impact


4.1 List of publications

AuthorsTitleYear, Issue, PPPartners NumberDoiPdf
Duc H. Le2017 19 210.1016/j.ebiom.2017.04.019Download
Golubeva AV, Joyce SA, Moloney G, Burokas A, Sherwin E, Arboleya S, Flynn I, Khochanskiy D, Moya-Pérez A, Peterson V, Rea K, Murphy K, Makarova O, Buravkov S, Hyland NP, Stanton C, Clarke G, Gahan CGM, Dinan TG, Cryan JF. Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism. 2017 24 166-17810.1016/j.ebiom.2017.09.020Download
Rizzetto L, Fava F, Tuohy KM, Selmi C.Connecting the immune system, systemic chronic inflammation and the gut microbiome: The role of sex2018 92 12-3410.1016/j.jaut.2018.05.008.Download
Ulaszewska MM, Mancini A, Garcia-Aloy M, Del Bubba M, Tuohy KM, Vrhovsek U.Isotopic dilution method for bile acid profiling reveals new sulfate glycine-conjugated dihydroxy bile acids and glucuronide bile acids in serum.2019 173 1-1710.1016/j.jpba.2019.05.002Download
Fava F, Rizzetto L, Tuohy KM.Gut microbiota and health: connecting actors across the metabolic system.2018 Dec 18 1-1210.1017/S0029665118002719Download
Mullish BH, McDonald JAK, Pechlivanis A, Allegretti JR, Kao D, Barker GF, Kapila D, Petrof EO, Joyce SA, Gahan CGM, Glegola-Madejska I, Williams HRT, Holmes E, Clarke TB, Thursz MR, Marchesi JR Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection 2019 gutjnl-2018-317842 10.1136/gutjnl-2018-317842Download
Koutsos, A, Riccadonna, S, Ulaszewska, MM, Franceschi, P, Trošt, K, Galvin, A, Braune, T, Fava, F, Perenzoni, D, Mattivi, F, Tuohy, KM, Lovegrove, J. Two apples a day lower serum cholesterol and improve cardiometabolic biomarkers in mildly hypercholesterolemic adults: a randomized, controlled, crossover trial. 2020;111:307–318. doi: 10.1093/ajcn/nqz282.Download
Ehud Rinott*, Ilan Youngster, , Anat Yaskolka Meir, Gal Tsaban, Hila Zelicha, Alon Kaplan, Dan Knights, Kieran Tuohy*, Francesca Fava*, Matthias Uwe Scholz*, Oren Ziv, Elad Reuven, Amir Tirosh, Assaf Rudich, Matthias Blüher, Michael Stumvoll, Uta Ceglarek, Karine Clement, Omry Koren, Dong D. Wang, Frank B. Hu, Meir J Stampfer, Iris Shai.The effect of autologous fecal microbiota transplantation on weight loss regain. 2021, 160(1): 158–173.e10. FEM and CABALA_diet&health named collaborator group, Iris Shai, Ben Gurion University of the Negev, Isrealdoi:10.1053/j.gastro.2020.08.041.Download
Anat Yaskolka Meir,1 Ehud Rinott*,1 Gal Tsaban,1,2 Hila Zelicha,1 Alon Kaplan,1 Philip Rosen,3 Ilan Shelef,3 Ilan Youngster,4 Aryeh Shalev,2 Matthias Blüher,5 Uta Ceglarek,6 Michael Stumvoll,5 Kieran Tuohy *,7 Camilla Diotallevi *,7,8 Urska Vrhovsek*,8 Frank Hu,9,10,11 Meir Stampfer,9,10,11 Iris ShaiEffect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial2021;0:1–11. FEM and CABALA_diet&health named collaborator group, Iris Shai, Ben Gurion University of the Negev, Isrealdoi:10.1136/gutjnl-2020-323106Download
Mastrocola R*, Collotta D*, Gaudioso G*, Le Berre M*, Cento AS*, Ferreira Alves G*, Chiazza F*, Verta R*, Bertocchi I*, Manig F*, Hellwig M*, Fava F*, Cifani C*, Aragno M*, Henle T*, Joshi L*, Tuohy K*, Collino M*.Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation2020, 12, 2497University of Turin and SALIVAGES team, FEM form CABALA_diet&healthdoi:10.3390/nu12092497 Download
Collotta D, Hull W, Mastrocola R, Chiazza F, Cento AS, Murphy C, Verta R, Alves GF, Gaudioso G, Fava F, Yaqoob M, Aragno M, Tuohy K, Thiemermann C, Collino M.Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice2020 Sep;39:101009.University of Turin and SALIVAGES team, FEM from CABALA_diet&healthdoi: 10.1016/j.molmet.2020.101009.Download
Lasalvia P, Gianfagna F, Veronesi G, Franchin M, Tozzi M, Castelli P, Grandi AM, Zambon A, Iacoviello L, Ferrario MM.Identification of dietary patterns in a general population of North Italian adults and their association with arterial stiffness. The RoCAV study2021 Jan 4;31(1):44-51USDIdoi: 10.1016/j.numecd.2020.08.001.Download
Prete R, Long SL, Joyce SA, Corsetti A.Genotypic and phenotypic characterization of food-associated Lactobacillus plantarum isolates for potential probiotic activities2020 May 1;367(10):fnaa076UCCdoi: 10.1093/femsle/fnaa076.Download
Geng W, Long SL, Chang YJ, Saxton AM, Joyce SA, Lin J.2020 Mar 18;10(1):4941UCCdoi: 10.1038/s41598-020-61723-7.Download
Prete R, Long SL, Gallardo AL, Gahan CG, Corsetti A, Joyce SA.2020 Jan 24;10(1):1165UCCdoi: 10.1038/s41598-020-58069-5.Download
Ulaszewska MM, Koutsos A, Trošt K, Stanstrup J, Garcia-Aloy M, Scholz M, Fava F, Natella F, Scaccini C, Vrhovsek U, Tuohy K, Lovegrove J, Mattivi F. Two apples a day modulate human:microbiome co-metabolic processing of polyphenols, tyrosine and tryptophan2020 Dec;59(8):3691-3714FEM, UoRdoi: 10.1007/s00394-020-02201-8
Camilla Diotallevi, Giulia Gaudioso, Francesca Fava, Andrea Angeli, Cesare Lotti, Urska Vrhovsek, Ehud Rinott, Iris Shai, Marco Gobbetti, Kieran TuohyMeasuring the effect of Mankai® (Wolffia globosa) on the gut microbiota and its metabolic output using an in vitro colon model2021 Vol 84https://doi.org/10.1016/j.jff.2021.104597Download
Rose-Anna G. Pushpass*, Shouq Alzoufairi*, Kim G. Jackson* and Julie A. Lovegrove*Circulating bile acids as a link between the gut microbiota and cardiovascular health: impact of prebiotics, probiotics and polyphenol-rich foods2021, AprilUoRdoi:10.1017/S0954422421000081Download
Joyce SA, Kamil A, Fleige L, Gahan CGM.The Cholesterol-Lowering Effect of Oats and Oat Beta Glucan: Modes of Action and Potential Role of Bile Acids and the Microbiome2019 Nov 27;6:171.UCCdoi: 10.3389/fnut.2019.00171. Download
Sarah Louise Long* and Susan A. Joyce*Bile Acids as Receptor Ligands in Metabolic Processes - The FXR Connection2019; 1:101.UCChttp://scholarsinsight.org/journals/current-issues/24-Article.pdfDownload
Susan JoyceConcentrations of fecal bile acids in participants with functional gut disorders and healthy controls.2021 accepted: Manuscript ID: metabolites-1325636UCCManuscript ID: metabolites-1325636

4.2 Presentation of the project

Target groupAuthorsMeans of communicationHyperlinkPdf
ScientistsJulie Lovegrove, The CABALA diet & health study at University of Reading, Consortium kick-off meeting, London, 2017Presentation
Scientists, studentsCamilla Pedersen, The CABALA diet & health study, Hugh Sinclair Unit of Human Nutrition, University of Reading, 2017 Presentation
ScientistsButhaina Alathari, The CABALA diet & health study at University of Reading, JPI HDHL Conference, Brussels/Belgium, 2017Presentation
Scientists, students, general public (volunteers)Buthaina Alathari, The Effect of Probiotic, Prebiotic, and Polyphenol Intake on Platelet Function – CABALA Diet and Health, Hugh Sinclair PhD symposium, University of Reading, 2018Presentation
ScientistsKieran Tuohy, Samantha Riccadona, Lisa Rizzetto, Francesca Fava, Introducing CABALA diet & health and related existing studies, Consortium kick-off meeting, London, 2017Presentation
ScientistsKieran Tuohy, Lisa Rizzetto, EUREGIO-EFA project (including descritption of CABALA_diet&health and possibilities for collaboration), 2nd EUREGIO-EFA scientific working group meeting. Hall, Austria, 2018Presentation, workshop
ScientistsMarynka Ulaszewska. “FEM contribution WP 5.4, FOODBALL” Annual FoodBall Project Meeting in Varna (Bulgaria), 31 August-1 September 2017Presentation, workshop
General publicKieran Tuohy, “Of men and microbes” – measuring how diet:microbe interactions in the gut can reduce chronic disease risk”; International Economic Festival, Trento, Italy, 2017Presentation
General publicIris Shai “What is the actual effects of MED diet on mobilization of human fat storage pools & cardio- metabolic health? Evidence from long-term clinical trials”. International Economic Festival, Trento, Italy, 2017Presentation
Undergraduate students (nutrition)Kieran Tuohy, “A role for polyphenols in shaping the structure and function of the gut microbiome.” University of Ulster, Coleraine, UK. 2017Lecture Presentation
Scientists, Medical doctorsKieran Tuohy “Gut microbiota composition, bile acid signalling and human health: CABALA_Diet&Health”. 9th Probiotics, Prebiotics, New Foods conference, Rome, Italy, 2017Presentation
Medical doctorsKieran Tuohy, “Microbiota-diet interactions in neurodegeneration, and in Parkinson’s disease”. The selection and management of advanced therapies in the Parkinson's disease in specialist centers (National Medical Conference on Parkinsons), Rovereto, Italy, 2018Presentation
Scientists, IndustryKieran Tuohy “Probiotic reverse engineering – choose your mechanism first then your strain”. 4th Microbiome R&D and Business Collaboration Forum: Europe and Probiotics Congress: Europe. Amsterdam, 2017.Presentation
Scientists, Industry,Kieran Tuohy, “Microbiome Modulation for Improved Metabolic Health.” ILSI-Taiwan Annual meeting & Scientific Symposium, Taipei, 2018Presentation
Scientists, IndustryKieran Tuohy “ILSI Europe activities related to ‘Human Microbiome & Health”. ILSI-Europe annual Meeting, Brussels, 2017Presentation
Scientists, Medical doctorsKieran Tuohy, “The gut microbiota and human health - a molecular cross-talk”. European Medical Association Annual Conference, London 2017Presentation
General public, Medical doctorsKieran Tuohy, “The gut microbiota and human health - a molecular cross-talk”. European Medical Association Annual Conference, London 2017 Video https://www.youtube.com/watch?v=hTVQTYRqH70Video
Medical doctors, ScientistsKieran Tuohy “Microbiota and fat tissue distribution”. Diabesità. Pisa, Italy, 2017Presentation
ScientistsKieran Tuohy “Gut microbiota functions: metabolism of nutrients and other food components.” POSITIVe Cost action meeting, Thessaloniki, 2017Presentation
General PublicAndrea Manchini, Francesca Fava, Kieran Tuohy, Siamo Europa Festival, 2018. Open-showcase of regional scientific projects funded by the EU, 3 day event, face-to-face meet the public.Meet the public face to face
Scientists, IndustryKieran Tuohy ILSI Europe Functional Foods Task force meeting, May 2018. ‘Microbiome Modulation for Improved Metabolic Health’. Brussels, 2018Presentation
General publicAlimentary Adventures- Western Gateway building UCC Spring Open Day- 17th May 2017 Meet the public face to face
Scientists /studentsOrganiser APC-ICL Postgraduate Symposium October 2017 (SLL)Presentation
Students teachersAll Ireland Schools of Pharmacy Conference (April 2017), Cork, Ireland: Impact of gut microbiota-mediated bile acid metabolism on the solubilization capacity of bile salt micelles and drug biopharmaceutical properties.Presentation
General publicScience for All Public forum and competition -finalist (April 2017), Cork, Ireland: Gut bacteria and medicines: “bugging” you to keep your health “afloat”.Presentation
General publicOctober 2017 An evening of Food at the Cornstore restaurant, Cork spoke to general public on the dietary components they were consuming and the microbes associated with fermented foodsPresentation
Students TeachersJune 2017 School representative at open days for entry students, CorkMeeting face to face
Academics & stakeholders & general publicTuohy, K. FOOD2030, PLOVDIV, Side event 6: Food in Regions – one health, from regionality to functionality. Date 13th June 2018, Venue: Sankt Petersburg Hotel, Plovdiv (BG)Presentation
Students, academics & stakeholdersKieran Tuohy, “Host:microbe cross talk in metabolic disease and healthy ageing - potential for dietary manipulation”, METAORGANISMS, MICROBIAL BIOREFINERIES AND HUMAN HEALTH, Fondazione Golinelli – Bologna, 18-19 June 2018.PresentationDownload
Academic & stakeholdersKieran Tuohy, “Microbiome and ageing – dietary microbiome modulation for improved mental and physical quality of life in old age”, at ‘Nutrition for the Ageing Brain: Moving Towards Clinical Applications’ Madrid, Spain 30– 31/08/2018Presentation
Academics, students, stakeholders & dieticiansKieran Tuohy, “The Prebiotic Effects of Whole-Grain Oats”, European Federation of the Associations of Dietitians Conference in Rotterdam, The Netherlands 28th-29thSeptember, 2018. Quaker SymposiumPresentation
Academics, students & stakeholders Kieran Tuohy, “Diet:Microbe interactions in the gut for improved health – talking molecules”, Microbiome R&D and Business Collaboration Forum: Europe, 20th to 22nd May, 2019Presentation
General publicUCC, November 2017 A series of back to back talks on Diet, microbes and health at Cork City GaolPresentation
General publicUCC, International Womens day interview for twitter and Facebook -6th March 2018Twitter/facebook
General publicUoR BBC4 Interview with Adrian Washbourne BBC Radio Science Unit 10th January 2018 broadcast as part of a four part documentary series in April 2018.Radio interview
Students & academicsDoctoral Research Conference 2019 University of Reading Film Contest - Vlog of the CABALA diet and health study by Shouq Alzoufairi (PhD student) submitted 29th April 2019Engagement focused website, blog or social media channel
Students & academicsPresentation in the UoR Food and Nutrition Science (FNS) weekly seminar, University of Reading, 22nd May 2019 - The effect of probiotic, prebiotic and polyphenol interventions on biomarkers of cardiometabolic health. Shouq Alzoufairi (PhD student)Presentation
Students & academicsJPI HDHL Science Vlog Contest - Vlog of the CABALA diet and health study by Dr Rose-Anna Pushpass and Shouq Alzoufairi (PhD student) February 20th 2019Engagement focused website, blog or social media channel
Students & academicsPresentation in the FNS Research Symposium, University of Reading, 21st February 2019 - The effect of probiotic, prebiotic and polyphenol interventions on biomarkers of cardiometabolic health. Shouq Alzoufairi (PhD student)Presentation
Students & academicsPresentation at research group meeting of UoR Nutrition Research Group: Update on the CABALA study presented by Dr Rose-Anna PushpassPresentation
Medicinal and specialist foods industryKieran Tuohy, Dr Schar (https://www.drschaer.com/ ), presentation including CABALA_diet&health, July 19th 2018, Trieste.Presentation
Food/confectionary industry & Ferraro MSc students in nutritionKieran Tuohy, “The Gut Microbiota in health and disease - role of diet”, Ferraro and Ferraro MSc in Food and Human Nutrition, University of Turin, January 18th 2019.Presentation
European nutrition societies, nutrition scientists, dieticians, medical experts, international food industryKieran Tuohy, 3th European Nutrition Conference, Federation of European Nutrition Societies (FENS) Dublin, Ireland. 15 – 18 October 2019. side event organized by ILSI EuropeOral presentationDownload
European nutrition societies, nutrition scientists, dieticians, medical experts, international food industryKieran Tuohy, 3th European Nutrition Conference, Federation of European Nutrition Societies (FENS) Dublin, Ireland. 15 – 18 October 2019. Side event organized by Quaker OatsOral presentationDownload
International / American nutrition community, food scientists, dieticians, medical experts, microbiome expertsKieran Tuohy, American Society for Nutrition annual convention, Nutrition 2020 Live Online, Pepsico organised "Healthy Microbiome Session", 1-4 June 2020.Oral presentationDownload
International (Japan) scientific community, food scientists, nutritionists, dieticians, medical experts, metabolomics expertsKieran Tuohy, International Conference on Polyphenols and Health 28 Nov - 01 Dec 2019 Kobe International Conference Center, Kobe, JapanOrla presentationDownload
International (Israeli) scientific community, food scientists, food engineers, nutritionists, dieticians, medical expertsKieran Tuohy, invited lecture, Technion, Hypha, Israel, December 16th 2020, online.Oral presentaitonDownload
International scientific community (Florida, USA), University of South FloridaKieran Tuohy, invited lecture, Microbiome Club, University of South Florida. 16th June 2021.Oral presentationDownload
Scientific community, analytical chemistry, metabolomics, food scienceSusan Joyce and UCC team, Irish Mass Spectrometry Meeting May 2021 1 post doc presentation, 4 posters
Scientific Community, microbiologySusan Joyce, Microbiology Society Ireland and UK April 2021Keynote lecture
Scientific and medical communitySusan Joyce, University College Cork Medical Research and Technology conference November 2020Invited lecture/speech
International scientific community, microbiome, microbiology, medical research communitiesSusan Joyce, 8th Microbiome Research and Development Industry Conference November 2020Keynote speaker, oral presentation
International scientific community, gut microbiome, microbiology, medical research communitiesAnirudh Jaisimha, Speaker APC Virtual Symposium on Non-communicable diseases and antimicrobial resistance, APC Microbiome IrelandInvited speaker, oral presentation
International scientific community, biochemistry, analytical chemistrySusan Joyce, Irish Mass Spectrometry Meeting May 2019Invited speaker, oral presentation
International scientific community, medical researchers, microbiology, gut microbiome communitiesSusan Joyce, Infection and Immunity Microbiome Symposium Bristol April 2019Keynote speaker, oral presentation
Scientific community, biochemistry, food science, nutrition, gut microbiome, human health communitiesSusan Joyce, Cost action Nutredox Conference October 2019, LisbonInvited speaker, Oral communication
Scientific community, probiotics, prebiotics, gut microbiota, nutrition, human health, international nutraceutical industry,Susan Joyce, The International Scientific Conference on Probiotics and Prebiotics 2018 BudapestInvited speaker, oral presentation
International scientific community, gut microbiome, nutrition, human healthSusan Joyce, Keystone Symposium, Canada 2018Keynote lecture, oral presentationDownload
International scientific community, medical and gastroenterology ocmmunitiesSusan Joyce, World Congress in Gastroenterology Rome, Italy 2018Keynote speaker, oral presentation
International scientific community, gut microbiome, functional foods, probiotics, prebiotics, international food/nutraceutical industrySusan Joyce and the UCC team, 7th International Human Microbiome Conference Kerry 201810 Posters; 3rd prize of 300 posters
International scientific community, gut health, biochemistry, nutrition, gastroenterologySusan Joyce and the UCC team, XXV International Bile Acid Meeting: Bile Acids in Health and Disease 2018 Conference 6th to 7th July 2018 Dublin, Ireland2 posters
International scientific community, gut microbiome, human healthy and disease risk, microbiologySusan Joyce, Exploring Human Host-Microbiome Interactions in Health and Disease 05–07 December 2018 Wellcome Genome Campus, UKDownload
General public - dissemination on gut microbiota in human health and diseaseUCC team, SAJ Interviewed by James Gallagher and recorded part thereof “Second genome” -recording and Pod cast- award winning series of BBCRadio4 Downloads >6.5 million Aired: 24 April 2018Radio, Link
General publicSusan Joyce UCC Cornstore Restaurant Limerick: Lay audience talks: Food for thought June 2019Oral pesentation
General publicSusan Joyce, UCC Cornstore Restaurant Cork: Lay audience talks: Love your Gut June 2018Oral presentation
General publicAnirudh Jaisimha UCC, Pint of Science Cork September 2020Oral presentation
University educationSarah Long UCC, Responsible for Transition year student Jan 2019
Sarah Long UCC, Cork Summer Agricultural Show –gut matters – information stand June 2018Oral presentation
Buthaina AlAthari (UoR PhD Student), 4th International Conference of JPI HDHL - Introduction to CABALA study. February 2018. Oral presentation
Dr Camilla Pedersen (UoR) ,A talk or presentation - Presentation at research group meeting Introduction to the CABALA study presented. February 2018. Oral presentation
Julie Lovegrove (UoF), British Nutrition Foundation (BNF) Webinar on Prebiotics ‘Prebiotics in our diet’. Professor 13th Dec 2018Webinar
Nutrition research communityJulie Lovegrove, (UoR) Invited presentation in the Winter Nutrition Society conference, Royal Society of Medicine, London, 4-5 December 2018: Optimal diet and lifestyle strategies for the management of cardio-metabolic risk. Title of presentation: Dietary Dilemmas over Fats and Cardiovascular Disease Risk. December 2018. Oral presentaiton
General public/international stakeholdersJulie Lovegrove (UoR) Kuwait Embassy, Cultural Visit. ‘Research in the Hugh Sinclair Unit of Human Nutrition’. Reading, UK. 12th Feb 2019.Oral presentation
Nutrition communityJulie Lovegrove, British Nutrition Foundation Task Force Report launch ‘Human gut microbiome: a new frontier for CVD’ London, UK, 27th Feb 2019. Oral presentation
Education - staff, students University of NevarraAngeles Moron Ortiz (MSc placement student) UoR: A talk or presentation - Presentation for the University of Nevarra MSc viva, 11th September 2019 – Circulating Bile Acids As Biomarkers of Metabolic Health – Analysis of the Impact of Different Diets on Body Composition, Food Intake, Blood Pressure and Gastrointestinal Symptoms, September 2019. Oral presentation
Julie Lovegrove UoR: Interview on Radio Berkshire and Talk Talk radio, 20th December 2019 - Two apples a day lower serum cholesterol and improve cardiometabolic biomarkers in mildly hypercholesterolemic adults/Introducing the CABALA study. December 2019. A press release, press conference or response to a media enquiry/interview -
Julie Lovegrove, UoR: A talk or presentation - Invited presentation at International conference. 13th Federation European Nutrition Societies (FENS) meeting. “Dietary bioactives and cardiovascular Health” Dublin, Ireland. March 2020. Oral presentation
Julie Lovegrove, UoR: A talk or presentation - Invited Keynote presentations at International conference on Chronic Diseases and Lifestyle. Presentation entitled ‘Diet and Cardiovascular Disease Risk’. Lahore, Pakistan.March 2020.Oral presentation
Nutrition research communityShouq Alzoufairi (PhD Student), UoR: at the Nutrition Society Summer Meeting 2021. Presentation entitled ‘The effect of probiotic, prebiotic, and polyphenol interventions on cardiometabolic disease risk markers: findings from the CABALA study’ virtual meeting. July 2021. A talk or presentation - Poster presentation
Rose-Anna Pushpass, UoR: Nutrition Society Summer Meeting 2021. Presentation entitled ‘The effect of probiotic, prebiotic and polyphenol interventions on gut hormones and markers of glycaemic control: findings from the CABALA study’ virtual meeting. July 2021. A talk or presentation - Poster presentation

4.3 List of submitted patents and other outputs

Patent licencePartners involvedYearInternational eu or national patentCommentPdf

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