The Working Group “@OBEDIS, Guidelines for Obesity Dietary Interventions Sharing” has worked on harmonization of the way randomized controlled trials (RCTs) are conducted in the field of obesity to allow sharing and merging of databases.
A RCT is a study design used to investigate the effectiveness of a new intervention or treatment. Patients are randomly assigned to a control group or an intervention group, hereby limiting bias.
To predict an individual’s response to obesity treatment it is necessary to harmonize and merge the data from multiple intervention studies. The response of patients with obesity to a certain treatment varies however greatly. In different studies variables are often not measured in the same way.
To make sure studies on obesity can be compared, is necessary to measure the same variables using the same method. To reach this aim the @OBEDIS project brought together 30 experts from 13 countries and organized an European workshop. The consortium and experts reached consensus on a minimal core set of variables to be used in all future trials. The consortium also completed a case study on 3 European clinical studies to check the relevance of the defined minimal core set of variables.
@OBEDIS provides a set of European guidelines for a minimal set of variables to include in future clinical trials on obesity. They can be used for each trail, regardless of the specific endpoints. Broad adoption of these guidelines will enable researchers to harmonize and merge data from multiple intervention studies. Studies across Europe may be pooled for better prediction of individuals’ responses to an intervention for obesity – ultimately leading to better patient care and improved obesity outcomes.
Guidelines on how to use the minimal set of variables are freely available, and a PDF version can be downloaded here.
The @OBEDIS project was funded within the JPI HDHL rapid action call “Working Groups on Diet-related Chronic Diseases” and ran from 2018 till 2019.The call aimed to assemble Working Groups of leading scientists in order to push forward the field of diet-related chronic diseases. By establishing working groups the JPI HDHL supported transnational cooperation and communication between individual researchers, research groups and research organisations in order to merge knowledge, data and research results.
Meet the @OBEDIS consortium
A symposium dedicated to @OBEDIS outcomes is scheduled during the European and International Congress of Obesity in May 2020.