ERA-HDHL cofunded call “Biomarkers for Nutrition and Health” (BioNH 2016)

Valerolactones and healthy Ageing: LInking Dietary factors, nutrient biomarkers, metabolic status and inflammation with cognition in older adults
VALID
2017-05-25
2019-09-30
Helene McNulty
Partner Organization Partner Country

1. Overall project description


1.1 Summary

The VALID consortium aims to validate plasma γ-valerolactones as stable biomarkers of catechin and procyanidin-rich foods and demonstrate their association with markers of inflammation and metabolic health status, and ultimately cognitive function in an ageing European population. The VALID project is based upon the existing TUDA cohort which is a unique resource designed to assess nutritional, genetic and lifestyle factors in relation to health and the prevention of age-related disease in 5,186 adults aged 60-102 years. The project results will contribute to the evidence needed to underpin future policies and help to create effective strategies to promote better health in ageing in the European Union.


1.2 Highlights

The VALID project has two exciting research outputs of interest, which have been organised in conjunction with sister project DERiVE (both funded under the same JPI ERA-HDHL 2017 cofunded call "Biomarkers for Nutrition and Health"):


Firstly, a published IMPACT article by Prof Helene McNulty and Prof Mary Ward: VALID - Valerolactones and healthy Ageining: Linking Dietary factors, nutrient biomarkers, metabolic status and inflammations with cognition in older adults & DERiVE - Depevelopment of Riboflavin biomarkers to relate dietary sources with status, gene-nutrient Interactions and Validated health Effects in adult cohorts. Impact (10) doi: 10.21820/23987073.2018.10.83. This is a timely publication that highlights the JPI projects and has been disseminated widely to relevant stakeholders and project websites: www.jpi-valid.com and www.derive-riboflavn.com.


Secondly, VALID and DERiVE are co-hosting a scientific symposium at The Federation of European Nutrition Societies (FENS) conference, Dublin, Ireland, 15-18 October 2019. The scientific syposium 'Validating novel biomarkers of dietary exposure to Riboflavin and Polyphenols and associated health impacts: Transnational DERiVE and VALID projects' will be held on Wednesday 16 October at 15.05-16.30 in the Wicklow Meeting Room, The Convention Centre, Dublin, Ireland. 


4. Impact


4.1 List of publications

AuthorsTitleYear, Issue, PPDoiPdf
Calder PC, Carding SR, Christopher G, Kuh D, Langley-Evans SC, McNulty H.A holistic approach to healthy ageing: how can people live longer, healthier lives?2018, 31(4), 439-45010.1111/jhn.12566
Hughes CF, McNulty H.Assessing biomarker status of vitamin B in the laboratory: no simple solution2018, 55(2),188-18910.1177/0004563217747907
Laird E, O’Halloran A, Carey D, O’Connor D, Kenny R, Molloy A.Voluntary fortification is ineffective to maintain the vitamin B12 and folate status of older Irish adults: evidence from the Irish Longitudinal Study on Ageing (TILDA)2018, 120(1), 111-12010.1017/S0007114518001356
McCann A, McNulty H, Rigby J, Hughes CF, Hoey L, Molloy AM, ... Moore A.Effect of Area-Level Socioeconomic Deprivation on Risk of Cognitive Dysfunction in Older Adults2018, 66(7), 1269-127510.1111/jgs.15258
Mena P, Ludwig IA, Tomatis VB, Acharjee A, Calani L, Rosi A, ... Del Rio D.Inter-individual variability in the production of flavan-3-ol colonic metabolites: preliminary elucidation of urinary metabotypes2018, 58(4), 1529-154310.1007/s00394-018-1683-4
Mena P, Bresciani L, Brindani N, Ludwig IA, Pereira-Caro G, Angelino D, ... Del Rio D.Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity2018, 5 10.1039/c8np00062j
Mills JL, Molloy AM, Reynolds EH.Do the benefits of folic acid fortification outweigh the risk of masking vitamin B deficiency?.2018, 360, k72410.1136/bmj.k724
Molloy AM, Mills JLFortifying food with folic acid to prevent neural tube defects: are we now where we ought to be?2018, 107(6), 857-85810.1093/ajcn/nqy110
Molloy AM.Should vitamin B status be considered in assessing risk of neural tube defects?2018, 1414(1), 109-12510.1111/nyas.13574
Moore K, Hughes CF, Ward M, Hoey L, McNulty H.Diet, nutrition and the ageing brain: current evidence and new directions2018, 77(2), 152-16310.1017/S0029665117004177
Moore K, Hughes CF, Hoey L, Ward M, Cunningham C, Molloy AM, ... McNulty HB-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study2019, 20(5), 551-55710.1016/j.jamda.2018.11.031
Ntlholang O, McCarroll K, Laird E, Molloy A, Ward M, McNulty H, ... Cunningham C.The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study2018, 120(5), 517-52710.1017/S0007114518001848
McNulty H.VALID - Valerolactones and healthy Ageing: LInking Dietary factors, nutrient biomarkers, metabolic status and inflammation with cognition in older adults2018, 10 10.21820/23987073.2018.10.83
Ziauddeen N, Rosi A, Del Rio D, Amoutzopoulos B, Nicholson S, Page P, ... Mena P.Dietary intake of (poly)phenols in children and adults: cross-sectional analysis of UK National Diet and Nutrition Survey Rolling Programme (2008-2014).2018 10.1007/s00394-018-1862-3
Martini D, Marino M, Angelino D, Del Bo’ C, Del Rio D, Riso P, Porrini M.Role of berries on vascular function: a systematic review of human intervention studies2019, In press, In press10.193/nutrit/nuz053

4.2 Presentation of the project

Target groupAuthorsMeans of communicationHyperlinkPdf
TUDA participantsDr Katie Moore, Prof Helene McNulty, Prof Mary Ward, Dr Chris Gill, Prof Adrian Moore, Dr Aoife Caffrey 'TUDA Information Event', Ulster University, Coleraine 30 October 2018Information event; oral presentation and discussion
TUDA participantsDr Katie Moore, Prof Helene McNulty, Prof Mary Ward, Dr Chris Gill, Prof Adrian Moore, Dr Aoife Caffrey 'TUDA Information Event', Ulster University, Coleraine 5 November 2018Information event; oral presentation and discussion
TUDA participantsProf Helene McNulty, Prof Mary Ward, Dr Chris Gill, Prof Adrian Moore, Dr Katie Moore, Dr Aoife Caffrey 'TUDA Information Event', Ulster University, Coleraine 30 May 2019Personal and patient involvement; round table discussion
TUDA participantsProf Helene McNulty, Prof Mary Ward, Dr Chris Gill, Prof Adrian Moore, Dr Katie Moore, Dr Aoife Caffrey 'TUDA Information Event', Ulster University, Coleraine 10 June 2019Personal and patient involvement; round table discussion
Scientists, general public, policy makersProf Helene McNulty, Member of the Northern Ireland Clinical Trials Unit (NCTU) Advisory Group, Northern Ireland 2018, 2019Guidance committee
Scientists, general public, policy makersProf Helene McNulty, 'Role of riboflavin in reducing blood pressure in genetically at-risk adults', EuroPrevent Congress, European Association of Preventative Cardiology, Ljubljana, Slovenia, April 2019Oral presentation
Scientists, general public, policy makersProf Helene McNulty, 'Nutrition and the ageing brain: can specific foods and nutrients preserve better cognition in older adults?'. Dementia 2018 Conference, Northern Ireland, May 2018Oral presentation
Scientists, general public, policy makersProf Helene McNulty 'Folate and related B-vitamins through the lifecycle - public health priorities and challenges', Nutrition Society Irish Section Conference, June 2018Oral presentation
Scientists, general public, policy makersProf Helene McNulty 'Folate and related B-vitamins in health & disease from early life to older age'. IACC Syposium Cellular Coenzymes in Health & Disease, London, UK, July 2018Oral presentation
Scientists, general public, policy makersProf Helene McNulty 'Riboflavin status, MTHFR and blood pressure'. FASEB Science Research Conference, Nova Scotia, Canada, August 2018Oral presentation
Scientists, general public, policy makersProf Helene McNulty 'Relationship between riboflavin, MTHFR and hypertension'. 5th International Vitamin Conference, Sydney, Australia, August 2018Oral presentation
Scientists, general public, policy makersProf Helene McNulty 'Effect of B-vitamin supplementation on cognitive performance in older age'. 5th International Vitamin Conference, Sydney, Australia, August 2018Oral presentation
Scientists, general public, policy makersProf Helene McNulty 'The health effects of folic acid fortification'. Bioavailability 2018: Understanding the bioavailability of micronutrients and bioactive compounds for improved public health, Norwich, UK, September 2018Oral presentation
Scientists, general public, policy makersProf Helene McNulty 'Achieving optimal folate status for health: natural food folates versus folic acid', 12th International conference on One Carbon Metabolism, B Vitamins and Homocysteine, Spain, 9th - 13th June 2019Oral presentation
Scientific, policy makersProf Adrian Moore 'Creating a European Deprivation Index for the Island of Ireland', INSERM and Université Caen Normandie, Caen, France, December 2018Oral presentation
Scientists, general public, policy makersProf Daniele Del Rio, Monthly Assignment Challenge - Contribution to Science & Wine online blog, February 2018Website articles
Schools, Scientists, general public, policy makers, studentsProf Daniele Del Rio 'Phenyl-γ-valerolactones and Phenylvaleric Acids, the Main Colonic Metabolites of Flavan-3-ols: Their Relevance in Berry Health Benefits'. • 8th Biennial Berry Health Benefits Symposium, Portland, Oregan, USA, May 2019Oral presentation
Schools, Scientists, general public, policy makers, studentsProf Daniele Del Rio 'Il Microbiota come Bersaglio Terapeutico'. University of Perugia, Italy, April 2019Oral presentation
Schools, Scientists, general public, policy makers, studentsProf Daniele Del Rio 'Polifenoli e salute: notizie dal fronte della ricerca'. INNOFOODMED. Bari, Italy, March 2019Oral presentation
ScientificDr Aoife Caffrey 'Science VLOG: VALID project', 5th International Conference of JPI HDHL, Brussels, February 2019Video log (vlog)
Scientists, general public, policy makers, studentsProf Mary Ward, UU is the Deputy Director of the Wellcome Trust - Wolfson Norhern Ireland Clinical Research Facility (NICRF), 2018, 2019Facilitating research
Schools, Scientists, general public, policy makers, studentsDr Donato Angelino, 'Valerolactones and healthy Ageing: Linking diet, biomarkers and metabolic health with cognition in older aduls - the VALID project', 39th Conference of the Italian Society of Human Nutrition, Italy, 2018Oral presentation
Schools, Scientists, general public, policy makers, studentsDr Donato Angelino, 'Valerolactones and healthy Ageing: Linking diet, biomarkers and metabolic health with cognition in older aduls - the VALID project', 2nd Food Bioactives and Health Conference, Lisbon, September 2018Oral presentation
ScientistsDr Donato Angelino, 'Workshop on Nutrition for the Ageing Brain: Moving Towards Clinical Applications', ILSI Europe Task Force on Nutrition and Mental Performance, Madrid, Spain, August 2018Workshop
Scientists, general public, policy makersDr Chris Gill, Monthly Assignment Challenge - Contribution to Science & Wine online blog, March 2018Website articles
Scientists and industryDr Chris Gill, 'Valerolactones and healthy Ageing: Linking diet, biomarkers and metabolic health with cognition in older adults: the VALID project', International Geneva/Springfield Symposium on Advances in Alzheimer Therapy (AAT) and AD/PDTM Meeting, Torino, Italy, March 2018Oral presenation

4.3 List of submitted patents and other outputs

Patent licencePartners involvedYearInternational eu or national patentCommentPdf

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