JPI HDHL JFA “Biomarkers for Nutrition and Health” (BioNH 2014)

TAGging dietary Fiber intake and their interest for health by measuring biomarkers related to the gut microbiota
FiberTAG
2017-04-15
2020-04-15
Delzenne
Partner Organization Partner Country

1. Overall project description


1.1 Summary

The FiberTAG project will establish a set of biomarkers linking dietary fiber (DF) intake and gut-microbiota related health effect. We aim at refining the concept of DF based on novel biological effects that can occur upon gut microbiota-nutrients interaction by using existing cohorts and by developing innovative approaches to evaluate the health interest of novel insoluble DF.


The FiberTAG consortium gathers 4 academic principal investigators from Belgium, France, Germany and Canada, respectively. They gather complementary research expertises such as 1) host physiology with emphasis on management of cardio-metabolic disorders, 2) intervention studies based on diet and prebiotic DF, 3) microbial ecology, 4) data integration and modelling. Two industrial partners (Kitozyme and Mondelez) will develop and provide selected insoluble fiber for the intervention studies.


Specific metabolites selected as biomarkers of microbiota-driven fermentation and gut-related functions will be analyzed in 5 existing cohorts of healthy or overweight  populations in which the fecal microbiota composition and DF intake have been (or will be) analyzed. New intervention studies will be performed in healthy and cardiometabolic risk volunteers to evaluate the interest for health of two insoluble fibers (chitin-glucan and a wheat bran fraction).



1.2 Highlights

Main outputs to be disseminated:


A repertoire and a food questionnaire for evaluation of DF intake taking into account their crucial role on key physiological parameters related to cardiometabolic risk and on health status


Innovative approaches to evaluate in intervention studies the health interest of novel insoluble DF, prone to interact with the gut microbiota


A set of novel innovative and non-invasive biomarkers linking DF intake and gut microbiota related health effect interesting to consider in the context of cardiometabolic risks


Chitin-glucan fiber : effects on the human intestinal microbiota, on the function and intestinal permeability through the selection of biomarkers of interest ; this will maybe allow to generate new health claims related to the investigated fibers (formulations: innovative administration forms)


Wheat bran: effects on the human intestinal microbiota, health interest, so as to promote the inclusion of wheat bran in products.


4. Impact


4.1 List of publications

AuthorsTitleYear, Issue, PPDoiPdf

4.2 Presentation of the project

Target groupAuthorsMeans of communicationHyperlinkPdf
JPI HDHL Pis, Nutrition expertsN. Delzenne. FiberTAG: TAGging dietary Fiber intake and their interest for health by measuring biomarkers related to the gut microbiota. Mid-Term JPI HDHL Symposia, The Hague (The Netherlands) July 2018Presentation of the FiberTAG project,
Scientists, Nutrition experts.Delzenne. Microbiota in NAFLD: is there room for innovative treatments? 40th ESPEN Congress on Clinical Nutrition & Metabolism. September, 2018Presentation
Scientists, Nutrition experts, agro-industriesN. Delzenne. Notre choix d’ingrédients alimentaires, gage de bonne santé ? FEVIA Event-Food Forward Event - Innovation by the Next Generation. Brussels, Belgium, April 2019Presentation
Scientists, Nutrition expertsN. Delzenne. Modulation du microbiote par les légumes riches en fibres: une approche thérapeutique prometteuse de l’obésité ? EGEA 2018 Nutrition & Santé: de la science à la pratique. Lyon, France November 2018Presentation
Scientists, Nutrition expertsN. Delzenne. Gut microbiome related recommendations for dietary fibres. 7th International DF Conference 2018 - Fibre Diversity in Food, Fermentation and Health Rotterdam, the Netherlands, June 2018Presentation
Scientists, Nutrition experts, general publicN. Delzenne. Recherche translationnelle en nutrition et santé : exemple de projets menés en région wallonne. Inauguration of the Center of Investigation in Clinical Nutrition, November 2018Presentation
CarMeN and CRNH-RA researchersJA Nazare. FiberTAG: TAGging dietary Fiber intake and their interest for health by measuring biomarkers related to the gut microbiota. CarMeN laboratory Symposia, Lyon July 2018Presentation
ResearchersAE Breyton. 1rst year PhD project report. Lyon Graduate school EDISS scientific committee, Lyon, September 2018Presentation
Researchers, attendantsJA Nazare. FiberTAG: TAGging dietary Fiber intake and their interest for health by measuring biomarkers related to the gut microbiota. Journées Francophones de Nutrition, Nice November 2018Presentation
Researchers, attendants, CRNH MembersJA Nazare. FiberTAG: TAGging dietary Fiber intake and their interest for health by measuring biomarkers related to the gut microbiota. Scientific committee, Lyon, February 2019Presentation
ScentistsWalter J. Dietary fibre, evolution, and the gut microbiome. AACC International Annual Meeting, San Diego, California, USA, October 2017.Presentation
ScientistsWalter J. Is there evidence that changes in the characteristics of the microbiota have a physiologic effect/functional outcome. ILSI North America Gut Microbiome Committee roundtable Event “Can a Healthy Gut Microbiome be Defined Through Quantifiable Characteristics”, Washington DC, December 2018.Presentation
ScientistsWalter J. Why are gut microbiomes individualized, and why does it matter for personalized nutritional approaches? Individualizing Medicine Conference, Mayo Clinic, Rochester, Minnesota, USA. September 2018.Presentation
Nutrition expertsB. Seethaler, S.C. Bischoff and all LIBRE PIs, 40th ESPEN Congress on Clinical Nutrition & Metabolism. September, 2018Presentation
Nutrition expertsB. Seethaler, S.C. Bischoff and all FiberTAG PIs FOOD2030 Congress Stuttgart, 2018Presentation
Scientists, policy makersS.C. Bischoff, Berlin, 2018Presentation
Nutrition expertsB. Seethaler, S.C. Bischoff. 5th JPI HDHL conference, Brussels (Belgium), February 2019JPI HDHL Vlog contest

4.3 List of submitted patents and other outputs

Patent licencePartners involvedYearInternational eu or national patentCommentPdf

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