There is a long-standing tracking of the risk of impaired glycaemic health being transmitted from one generation
to another that is hypothesised to causally link exposure to adverse glycaemic health in pregnancy and the
offspring glycaemic health via epigenetic mechanisms. The potential biological and nutritional pathways
underlying the paradigm can be of paramount importance to understand, prevent or reverse the consequences of
gestational diabetes for life-long obesity, glycaemic adversity and type 2 diabetes; the key outcomes here.
PREcisE will aim to answer the expected impact of the call focusing on causality, nutrition and tissue specificity.
Causality will be tested by three complementary design: randomised control trial, mendelian randomisation and
causal modelling including triangulation to validate results. Tissue-specific molecular pathways will be addressed
by a unique transcriptomic-DNAmethylation approach.
PREcisE project will aim to bring sufficient evidence to three key exploitable results: DNA methylation risk
scores at maternal glucose response loci for precision epigenetics, dietary recommendations to help optimising the
DNA methylation at these loci and a life-course model to inform policy on the long-lasting effects and opportunity
to promote life-long glycaemic health.