Paternal RNA-mediated epigenetic inheritance of metabolic disorders: impact of weight loss on the human sperm epitranscriptome

ERA-HDHL JFA2 “Nutrition & the Epigenome” (Epigenome)
Paternal RNA-mediated epigenetic inheritance of metabolic disorders: impact of weight loss on the human sperm epitranscriptome
HEROS
2019-01-01
0000-00-00
Valerie Grandjean
C3M, Inserm U1065
France

Consortium

Partner Organization Partner Country
Institut d'Investigació Biomèdica de GironaSpain
Institute of Pharmacy and BiochemistryGermany

1. Overall project description


1.1 Summary

Increasing evidence suggests that several non-communicable diseases, including obesity and its associated
metabolic disorders, are inherited from parents to offspring over several generations by non-genetic mechanisms.
In this context, it has been suggested that parental environmental cues might induce epigenetic modifications in
the germ line, which are transmitted to the progeny. Hence, etiological and risk factors that contribute to the
insurgence of non-communicable diseases have the potential to drive the development of pathology(ies) in the
progeny.

This work will contribute to a better understanding of the molecular mechanisms involved in the non-genetic
inheritance of obesity in human, and to the identification of obese-susceptibility loci whose expression can be
modulated by environmental factors and consequently induce the development of the disease in successive
generations.


1.2 Highlights


4. Impact


4.1 List of publications

AuthorsTitleYear, Issue, PPDoiPdf

4.2 Presentation of the project

Target groupAuthorsMeans of communicationHyperlinkPdf

4.3 List of submitted patents and other outputs

Patent licencePartners involvedYearInternational eu or national patentCommentPdf

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