Partner Organization | Partner Country |
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Trinity College Dublin | Ireland |
University of Parma | Italy |
The VALID project aims to validate plasma valerolactones as stable biomarkers of catechin- and procyanidin- rich foods and to demonstrate their association with markers of metabolic health, inflammation and cognitive function in an older European population, building upon the existing TUDA study of 5,186 older adults. The VALID project has 5 objectives, to evaluate:
Results: The data analysis is still ongoing, but the novel findings so far suggest that plasma PVLs are reliable biomarkers of polyphenol rich foods and may be beneficial to cognitive health, underpinned by important socioeconomic factors. Ongoing data analysis will include investigation of PVLs as modulators of inflammation, providing a potential mechanism linking dietary polyphenols with cognitive function in older adults. In relation to the analysis of PVLs and related dietary polyphenols, the results showed that of the 9 PVLs quantified in TUDA samples, 3 plasma fractions were identified as being predominant: 5-(4´-Hydroxyphenyl)-γ-VL-3´-sulfate isomers followed by 5-(4´-Hydroxyphenyl)-γ-VL-3´-glucuronide and its isomer 5-(5´-Hydroxyphenyl)-γ-VL-3´-glucuronide. These PVLs were significantly correlated with dietary polyphenol intakes and may be reliable biomarkers of flavan-3-ol-rich foods. In relation to cognitive health, the results showed that PVLs concentrations were significantly lower in older adults with cognitive dysfunction compared to age- sex-matched participants with normal cognitive function. Using Geographic Information Science (GIS) technologies to integrate nutrition with environmental and socioeconomic data, the results showed that the area in which a person lives (particularly area-based deprivation), and the nature/distribution of food outlets (‘Foodscapes’) determining access to healthy versus unhealthy foods, may have important influences on food consumption, nutrition and health.
Expected impacts
Most important results from the VALID project:
Publication and Event highlights from the VALID project:
Authors | Title | Year, Issue, PP | Partners Number | Doi | |
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Angelino D*, Paramenter B*, Moore K*, Gill C*, Mena P*, Rosi A*, ... McNulty H* | Valerolactones and healthy Ageing: Linking Dietary factors, nutrient biomarkers, metabolic status and inflammation with cognition in older adults - The VALID Project. | 10.1016/j.numecd.2019.05.017 | |||
Angelino D*, Caffrey A*, Moore K*, Laird E*, Moore AJ*, Gill CIR*, Mena P*, Westley K*, Pucci B*, Boyd K*, Mullen B*, McCarroll K*, Ward M*, Strain JJ*, Cunningham C*, Molloy AM*, McNulty H*, Del Rio D* | Phenyl-γ-valerolactones and healthy ageing: linking dietary factors, nutrient biomarkers, metabolic status and inflammation with cognition in older adults (The VALID Project) | 10.1111/NBU.12444 | |||
B. Parmenter*, K. Moore*, D. Angelino*, D. Del Rio*, H. McNulty*, A.M. Molloy*, C. Cunningham*, M. Ward*, B. Pucci*, H. Jarrett, E. Laird*, J.J. Strain*, A. Moore* and C.I.R. Gill* | Validity of plasma phenyl-γ-valerolactones as novel biomarkers of dietary (poly)phenols: Preliminary analysis from the VALID project | 10.1017/S0029665118001040 | |||
Mena P*, Bresciani L, Brindani N, Ludwig IA, Pereira-Caro G, Angelino D*, ... Del Rio D* | Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity | 10.1039/c8np00062j | |||
Ward M*, McNulty H* | DERIVE - Development of Riboflavin biomarkers to relate dietary sources with status, gene-nutrient Interactions and Validated health Effects in adult cohorts - & VALID - Valerolactones and healthy Ageing: LInking Dietary factors, nutrient biomarkers, metabolic status and inflammation with cognition in older adults | 10.21820/23987073.2018.10.83 | |||
Calder PC, Carding SR, Christopher G, Kuh D, Langley- Evans SC, McNulty H* | A holistic approach to healthy ageing: how can people live longer, healthier lives? | 10.1111/jhn.12566 | |||
Angelino D*, Godos J, Ghelfi F,...., Del Rio D*, Grosso G | Fruit and vegetable consumption and health outcomes: an umbrella review of observational studies | 10.1080/09637486.2019.1571021 |
Target group | Authors | Means of communication | Hyperlink | |
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Scientists, general public, policy makers, professional practitioners | Prof Daniele Del Rio*, 'Dietary polyphenols, circulating valerolactones and cognitive health in older Europeans - The VALID Project', DERiVE-VALID Symposium, FENS 13th European Nutrition Conference, Dublin, Ireland 2019 | Oral presentation | ||
Scientists, general public, policy makers, professional practitioners | Prof Adrian Moore*, 'Understanding and promoting cognitive health in ageing through integration of dietary information with physical and social environments in the VALID project', , DERiVE-VALID Symposium, FENS 13th European Nutrition Conference, Dublin, Ireland 2019 | Oral presentation | ||
Scientists, general public, policy makers, professional practitioners | Prof Helene McNulty*, Co-chair of the Executive Committee, FENS 13th European Nutrition Conference, Dublin, Ireland, 2019 | Committee member/ Oral presentation | ||
Scientists, general public, policy makers, professional practitioners | Prof Pedro Mena*, ''A comprehensive approach to the bioavailability and cardiometabolic effects of the bioactive compounds present in espresso coffee and confectionery-derived coffee', FENS 13th European Nutrition Conference, Dublin, Ireland, 2019 | Oral presentation | ||
Scientists, general public, policy makers | Prof Mary Ward*, Prof Sean JJ Strain*, Members of the Organising Committee at the FENS 13th European Nutrition Conference, Dublin, Ireland, 2019 | Commiittee members | ||
Scientists, general public, policy makers, professional practitioners | Prof Anne Molloy*, “Interactions between folate excess and vitamin B12 deficiency”, Expert panel for the workshop on Metabolic Interaction between excess Folates/Folic acid and Vitamin B12 deficiency, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, ODS and USDA, National Institutes of Health, USA), 31st July-1st August 2019 | Oral presentation | ||
TUDA participants | Dr Katie Moore*, Prof Helene McNulty*, Prof Mary Ward*, Dr Chris Gill*, Prof Adrian Moore*, Dr Aoife Caffrey*, 'TUDA Information Event', Ulster University, Coleraine 5 November 2018 | Information event; oral presentation and discussion | ||
TUDA participants | Dr Katie Moore*, Prof Helene McNulty*, Prof Mary Ward*, Dr Chris Gill*, Prof Adrian Moore*, Dr Aoife Caffrey*, 'TUDA Information Event', Ulster University, Coleraine 30 October 2018 | Information event; oral presentation and discussion | ||
TUDA participants | Prof Helene McNulty,* Prof Mary Ward*, Dr Chris Gill*, Prof Adrian Moore*, Dr Katie Moore*, Dr Aoife Caffrey*, 'TUDA Information Event', Ulster University, Coleraine 30 May 2019 | Personal and patient involvement; round table discussion | ||
TUDA participants | Prof Helene McNulty*, Prof Mary Ward*, Dr Chris Gill*, Prof Adrian Moore*, Dr Katie Moore*, Dr Aoife Caffrey*, 'TUDA Information Event', Ulster University, Coleraine 10 June 2019 | Personal and patient involvement; round table discussion | ||
Scientists, general public, policy makers | Prof Helene McNulty*, Member of the Northern Ireland Clinical Trials Unit (NCTU) Advisory Group, Northern Ireland 2018, 2019 | Guidance committee | ||
Scientists, general public, policy makers | Prof Helene McNulty*, 'Role of riboflavin in reducing blood pressure in genetically at-risk adults', EuroPrevent Congress, European Association of Preventative Cardiology, Ljubljana, Slovenia, April 2019 | Oral presentation | ||
Scientists, general public, policy makers | Prof Helene McNulty*, 'Nutrition and the ageing brain: can specific foods and nutrients preserve better cognition in older adults?'. Dementia 2018 Conference, Northern Ireland, May 2018 | Oral presentation | ||
Scientists, general public, policy makers | Prof Helene McNulty*, 'Folate and related B-vitamins through the lifecycle - public health priorities and challenges', Nutrition Society Irish Section Conference, June 2018 | Oral presentation | ||
Scientists, general public, policy makers | Prof Helene McNulty*, 'Folate and related B-vitamins in health & disease from early life to older age'. IACC Syposium Cellular Coenzymes in Health & Disease, London, UK, July 2018 | Oral presentation | ||
Scientists, general public, policy makers | Prof Helene McNulty*, 'Riboflavin status, MTHFR and blood pressure'. FASEB Science Research Conference, Nova Scotia, Canada, August 2018 | Oral presentation | ||
Scientists, general public, policy makers | Prof Helene McNulty*, 'Relationship between riboflavin, MTHFR and hypertension'. 5th International Vitamin Conference, Sydney, Australia, August 2018 | Oral presentation | ||
Scientists, general public, policy makers | Prof Helene McNulty*, 'Effect of B-vitamin supplementation on cognitive performance in older age'. 5th International Vitamin Conference, Sydney, Australia, August 2018 | Oral presentation | ||
Scientists, general public, policy makers | Prof Helene McNulty*, 'The health effects of folic acid fortification'. Bioavailability 2018: Understanding the bioavailability of micronutrients and bioactive compounds for improved public health, Norwich, UK, September 2018 | Oral presentation | ||
Scientists, general public, policy makers | Prof Helene McNulty*, 'Achieving optimal folate status for health: natural food folates versus folic acid', 12th International conference on One Carbon Metabolism, B Vitamins and Homocysteine, Spain, 9th - 13th June 2019 | Oral presentation | ||
Scientific, policy makers | Prof Adrian Moore *,'Creating a European Deprivation Index for the Island of Ireland', INSERM and Université Caen Normandie, Caen, France, December 2018 | Oral presentation | ||
Scientists, general public, policy makers | Prof Daniele Del Rio*, Monthly Assignment Challenge - Contribution to Science & Wine online blog, February 2018 | Website articles | ||
Schools, Scientists, general public, policy makers, students | Prof Daniele Del Rio*, 'Phenyl-γ-valerolactones and Phenylvaleric Acids, the Main Colonic Metabolites of Flavan-3-ols: Their Relevance in Berry Health Benefits', 8th Biennial Berry Health Benefits Symposium, Portland, Oregan, USA, May 2019 | Oral presentation | ||
Schools, Scientists, general public, policy makers, students | Prof Daniele Del Rio*, 'Il Microbiota come Bersaglio Terapeutico'. University of Perugia, Italy, April 2019 | Oral presentation | ||
Schools, Scientists, general public, policy makers, students | Prof Daniele Del Rio*, 'Polifenoli e salute: notizie dal fronte della ricerca'. INNOFOODMED. Bari, Italy, March 2019 | Oral presentation | ||
Scientific | Dr Aoife Caffrey*, 'Science VLOG: VALID project', 5th International Conference of JPI HDHL, Brussels, February 2019 | Video log (vlog) | ||
Scientists, general public, policy makers, students | Prof Mary Ward*, UU is the Deputy Director of the Wellcome Trust - Wolfson Norhern Ireland Clinical Research Facility (NICRF), 2018, 2019 | Facilitating research | ||
Schools, Scientists, general public, policy makers, students | Dr Donato Angelino*, 'Valerolactones and healthy Ageing: Linking diet, biomarkers and metabolic health with cognition in older aduls - the VALID project', 39th Conference of the Italian Society of Human Nutrition, Italy, 2018 | Oral presentation | ||
Schools, Scientists, general public, policy makers, students | Dr Donato Angelino*, 'Valerolactones and healthy Ageing: Linking diet, biomarkers and metabolic health with cognition in older aduls - the VALID project', 2nd Food Bioactives and Health Conference, Lisbon, September 2018 | Oral presentation | ||
Scientists | Dr Donato Angelino*, 'Workshop on Nutrition for the Ageing Brain: Moving Towards Clinical Applications', ILSI Europe Task Force on Nutrition and Mental Performance, Madrid, Spain, August 2018 | Workshop | ||
Scientists, general public, policy makers | Dr Chris Gill*, Monthly Assignment Challenge - Contribution to Science & Wine online blog, March 2018 | Website articles | ||
Scientists and industry | Dr Chris Gill*, 'Valerolactones and healthy Ageing: Linking diet, biomarkers and metabolic health with cognition in older adults: the VALID project', International Geneva/Springfield Symposium on Advances in Alzheimer Therapy (AAT) and AD/PDTM Meeting, Torino, Italy, March 2018 | Oral presenation | ||
Scientists, general public, policy makers, professional practitioners | Prof Mary Ward*, Prof Helene McNulty*, 'Impact article on nutritional biomarkers for health - DERiVE and VALID Projects' | Impact article |
Patent licence | Partners involved | Year | International eu or national patent | Comment |
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