Dietary modulation of intestinal microbiota as trigger of liver health: role of bile acids

HDHL INTIMIC cofunded call “Interrelation of the Intestinal Microbiome, Diet and Health” (IM 2017)
Dietary modulation of intestinal microbiota as trigger of liver health: role of bile acids
Di-Mi-Liv
2018-04-01
2021-03-31
Prof. Dr. Ina Bergheim
University of Vienna
Austria

Consortium

Partner Organization Partner Country
University Clinic RWTH AachenGermany
Medical University of ViennaAustria
University of GothenburgSweden
University of HohenheimGermany

1. Overall project description


1.1 Summary

Non-alcoholic fatty liver disease (NAFLD) is by now the most common liver disease worldwide. A genetic predisposition and general overnutrition, alterations of intestinal microbiota composition and associated impairments of intestinal barrier function are thought to be critical in the onset and progression of NAFLD. Recent data further suggest a pivotal role of bile acids and microbial bile acid metabolism as mediators of gut-liver-crosstalk subsequently affecting NAFLD initiation and progression. Soluble fibers like oat β-glucans have been shown to bind bile acids and modulate intestinal microbiota composition thereby affecting metabolic parameters and liver health. Furthermore, results of human intervention trials suggest that manipulating intestinal microbiota composition through prebiotics may improve disease progression of NAFLD. However, the molecular mechanisms involved remain incompletely understood and established therapeutic strategies are still missing. Based upon this background the main aim of the translational project is to study the causal relationship between specific diet-responsive microbial taxa and alterations of the bile acid pool as risk factor for initiation and progression of metabolic liver diseases.


1.2 Highlights

Not applicable so far, as work is still in progress.


4. Impact


4.1 List of publications

AuthorsTitleYear, Issue, PPDoiPdf
Ina Bergheim, Hanns-Ulrich Marschall, Kai Markus Schneider, Christian TrautweinIntestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis2019http://dx.doi.org/10.1136/gutjnl-2018-316670
Kai Markus Schneider, Christian TrautweinIntestinal microbiota protects against MCD diet induced steatohepatitis201910.3390/ijms20020308

4.2 Presentation of the project

Target groupAuthorsMeans of communicationHyperlinkPdf
International Hepatology Community Ina Bergheim, Hanns-Ulrich Marschall, Kai Markus Schneider, Christian Trautwein, Talk: : “Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis”, EASL ILC, Vienna 2019Oral Presentation

4.3 List of submitted patents and other outputs

Patent licencePartners involvedYearInternational eu or national patentCommentPdf

BACK

We use cookies to improve our website and your experience when using it. By continuing to navigate this site, you agree to the cookie policy. To find out more about the cookies we use and how to delete them, see our privacy policy.

  I accept cookies from this site.
EU Cookie Directive Module Information