Tailored Carbohydrate Quality for Personalized Weight Management and Metabolic Health
|Partner Organization||Partner Country|
|Università degli Studi di Torino||Italy|
|University of Barcelona||Spain|
|University of Hohenheim||Germany|
|Bellvitge Biomedical Research Institute (IDIBELL)||Spain|
|SLU-Swedish University of Agricultural Sciences||Sweden|
1. Overall project description
This project investigates the role of carbohydrate quality (CQ) on weight management, appetite and cardiometabolic health in humans as well as underlying mechanisms by which CQ affects consumers. It will also promote career development and mobility of Early Career Scientists (ECS) to foster the new generation of scientists in food and health. Experimental models, clinical approaches and OMICs are used in a multidisciplinary setting. Results will be transferred to industry and disseminated to the scientific community and general public. We take advantage of the data and samples from 12-wk weight-loss study conducted in collaboration with Agrifood industry, investigating weight- and fat-loss after a high fibre vs refined fibre diet. Satiety and gut microbiota are currently evaluated as determinants of weight-loss and we will analyze cardiometabolic risk factors and molecular phenotypes associated with weight-loss and cardiometabolic risk profiles using metabolomics and proteomics. Molecular signatures of successful weight-loss and low cardiometabolic risk, will be validated in a prospective cohort of women (n=5022, data already available), and in a corresponding cohort in men (n=6000, data will be available during 2020). Moreover, a rat model will be used to study the potential adverse effects of refined carbohydrates at organ/tissue level and the potential beneficial effects of supplementation with fermentable dietary fibre. Particular focus will be put on metabolic inflammation and effects mediated through AGEs, the gut barrier and microbiota. We will compare preclinical metabolite profiles to metabolic signatures of the human studies to elucidate the molecular alterations associated with weight-loss and cardiometabolic risk in humans.
In summary, we will exploit (i) metabolomics to discover biomarker panels that can predict tailored advice on high-fibre diets for successful weight-loss (personalized nutrition), (ii) mechanistic studies to identify molecular mechanisms evoked by carbohydrates and (iii) the relationship between perceived satiety and food structure.
Results are expected to translate into improved high-fibre foods tailored for optimal metabolic health and weight management for individuals or consumer groups.
It is too early to communicate results at this stage.
It is too early to make any conclusions at this stage. The focus has been on data generation and study planning. It has been progressing smoothly despite COVID-19 and data is currently analysed.
The microstructure of in vitro digested wheat and rye products was very different, with a higher degree of disintegration on wheat products. This will be of relevance when combining with results of metabolomics analysis from the intervention studies.
4.1 List of publications
|Authors||Title||Year, Issue, PP||Partners Number||Doi|
|MhD Omar NA*, Dicksved J, Kruger J, Zamaratskaia G, Michaelssson K*, Wolk A*, Frank J*, Landberg R*:||Effects of a diet rich in galactose or fructose, with or without fructooligosaccharides, on gut microbiota composition in rats||Volume65, Issue6 March 2021||3||2001133|
|Raffaella Mastrocola, Debora Collotta*, Giulia Gaudioso, Marie Le Berre, Alessia Sofia Cento, Gustavo Ferreira Alves* , Fausto Chiazza* , Roberta Verta , Ilaria Bertocchi, Friederike Manig, Michael Hellwig, Francesca Fava , Carlo Cifani , Manuela Aragno, Thomas Henle, Lokesh Joshi, Kieran Tuohy and Massimo Collino*||Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation.||2020, 12(9):2497.||1||doi: 10.3390/nu12092497|
4.2 Presentation of the project
|Target group||Authors||Means of communication||Hyperlink|
|Scientists, industry and health care staff||Landberg, Rikard. Metabolomics to guide personalized cereal food consumption - emerging results from human studies. HealthGrainForum Webinar on "Personalisation of Grain Consumption" September 16, 2020.||Invited webinar presentation|
|Scientists, industry||Landberg, Rikard. The role of grains in sustainable & personalized nutrition 4 health. HealthGrainForum autumn meeting, November 5-6||Invited webinar presentation|
|Scientists||Anne K Eriksen , Carl Brunius , Mohsen Mazidi , Per M Hellström , Ulf Risérus , Kia N Iversen, Rikard Fristedt , Li Sun , Yi Huang, Natalja P Nørskov, Knud Erik B Knudsen , Cecilie Kyrø , Anja Olsen , Anne Tjønneland, Johan Dicksved, Rikard Landberg. Effects of whole-grain wheat, rye and lignan supplementation on cardio-metabolic risk factors in men with metabolic syndrome: a randomized crossover trial. Nordic Nutrition Conference, Helsinki 15-16 December 2020.||Invited oral presentation at the conference (through zoom)|
|Industry and scientist||Industry and scientists Landberg, Rikard. Rye, gut microbiota and cardio-metabolic health. Symposium: Rye-The “wholy” grain for gut and brain, Nordic Nutrition Conference 15 December 2020||Invited oral presentation at the symposium|
|Industry||Cristina Andres-Lacueva, polyphenol and biomarkers assement, July 15th, 2020||Invited oral, webinar, industrial training, online|
|Scientist , Open access||Pol Castellano Ontology, FOBI, POMA||Invited webinar|
|Scientist, Industry, health care staff||Tomas Meroño, Andrea Unión Caballero, Cristina Andrés-Lacueva. Importance of omics sciences in biotechnology. III Congress of Food science, Nutrition and Dietetics organized by the Spanish Academy of Nutrition and Dietetics. 23-27 November 2020.||Invited webinar presentation at the symposium|
4.3 List of submitted patents and other outputs
|Patent licence||Partners involved||Year||International eu or national patent||Comment|