Early life programming of childhood health: a nutritional and epigenetic investigation of adiposity and bone, cardiometabolic, neurodevelopmental and respiratory health

ERA-HDHL cofunded call “Biomarkers for Nutrition and Health” (BioNH 2016)
Early life programming of childhood health: a nutritional and epigenetic investigation of adiposity and bone, cardiometabolic, neurodevelopmental and respiratory health
ALPHABET
2017-01-01
2021-11-30
Dr Catherine Phillips
University College Dublin
Ireland

Consortium

Partner Organization Partner Country
Nofer Institute of Occupational MedicinePoland
Erasmus University RotterdamThe Netherlands
National Institute of Health and Medical Research (INSERM)France
University of BristolUnited Kingdom
University of SouthamptonUnited Kingdom

1. Overall project description


1.1 Summary

According to the Developmental Origins of Health and Disease hypothesis early life exposure to environmental factors plays a critical role in defining offspring health in childhood and later life. Thus adaptation to suboptimal nutrition during pregnancy or early childhood may perpetuate intergenerational transmission of a range of adverse health outcomes. Epigenetic phenomena have been proposed as potential mediating mechanisms. Novel associations between selected early life exposures and offspring epigenome and health have been reported. However the complexity of intergenerational whole diet-health-epigenome associations is not fully understood.


The ALPHABET project aims to address this gap. This consortium brings together 7 partners from Ireland, UK, France, The Netherlands, Poland and the US and 8 European longitudinal birth cohorts which are at the international forefront of lifecourse epidemiology.This project will allow us to go beyond the limits of individual cohorts to try to identify and validate diet-health-epigenome relationships across multiple populations. Using dietary, clinical and epigenetic data and biological samples from these cohorts, this project will advance the state-of-the-art by significantly expanding the knowledge base regarding the relationships between maternal dietary environment (defined by dietary quality and inflammatory potential), offspring health outcomes (including adiposity, bone, cardiometabolic, respiratory and neurodevelopmental health) and offspring epigenetics (DNA methylation) from birth throughout childhood.


The main objectives are to:


1: Harmonise data from participating birth cohorts


2: Perform epigenetic profiling of archived samples


3: Generate dietary inflammatory indices (DII) and dietary quality scores (DASH)


4: Determine maternal diet effects on offspring health and epigenetics


Results: Our findings from a series of individual participant data meta-analyses suggest that suboptimal maternal diet (low quality/pro-inflammatory diet) in pregnancy is i) associated with lower birth size and increased risk of delivering a small-for-gestational-age baby (n=24, 861 mother-child pairs), ii) greater risk of late childhood overweight and obesity (n=16,295 mother-child pairs), iii) moderate increased risk of childhood anxiety, aggression, depressive and ADHD symptoms (n= 11,870 mother-child pairs), iv) negatively associated with offspring bone outcomes (n=7,780 mother-child pairs) and v) not linearly associated with child's wheezing or asthma (n=18,326 mother-child pairs), with limited evidence of maternal diet influence on epigenetics. Impact: Our results may have public health implications in terms of informing the development of more effective evidence-based public health strategies with an emphasis on advocating a healthy/less pro-inflammatory diet in pregnancy to optimise fetal growth, reduce obesity and attenuate development of a range of adverse childhood health outcomes.


1.2 Highlights

Highlights from the ALPHABET project include the following publications:


Associations of maternal dietary inflammatory potential and quality with offspring birth outcomes: An individual participant data pooled analysis of 7 European cohorts in the ALPHABET consortium. Chen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, Mehegan J, Suderman M, Polanska K, Hanke W, Trafalska E, Relton CL, Crozier SR, Harvey NC, Cooper C, Duijts L, Heude B, Hébert JR, McAuliffe FM, Kelleher CC, Phillips CM.PLoS Med. 2021 Jan 21;18(1):e1003491. doi: 10.1371/journal.pmed.1003491.


Maternal dietary quality, inflammatory potential and childhood adiposity: an individual participant data pooled analysis of seven European cohorts in the ALPHABET consortium. Chen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, Mehegan J, Suderman M, Polanska K, Hanke W, Jankowska A, Relton CL, Crozier SR, Harvey NC, Cooper C, Hanson M, Godfrey KM, Gaillard R, Duijts L, Heude B, Hébert JR, McAuliffe FM, Kelleher CC, Phillips CM.BMC Med. 2021 Feb 22;19(1):33. doi: 10.1186/s12916-021-01908-7.


Dietary Quality and Dietary Inflammatory Potential During Pregnancy and Offspring Emotional and Behavioral Symptoms in Childhood: An Individual Participant Data Meta-analysis of Four European Cohorts. Polanska K, Kaluzny P, Aubert AM, Bernard JY, Duijts L, El Marroun H, Hanke W, Hébert JR, Heude B, Jankowska A, Mancano G, Mensink-Bout SM, Relton C, Shivappa N, Suderman M, Trafalska E, Wesolowska E, Garcia-Esteban R, Guxens M, Casas M, Phillips CM.Biol Psychiatry. 2021 Mar 15;89(6):550-559. doi: 10.1016/j.biopsych.2020.10.008.


Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children. Mensink-Bout SM, van Meel ER, de Jongste JC, Annesi-Maesano I, Aubert AM, Bernard JY, Chen LW, Cooper C, Crozier SR, Hanke W, Harvey NC, Hébert JR, Heude B, Jerzynska J, Kelleher CC, Mehegan J, McAuliffe FM, Phillips CM, Polanska K, Relton CL, Shivappa N, Suderman M, Jaddoe VWV, Duijts L. Eur Respir J. 2021 Sep 9:2101315. doi: 10.1183/13993003.01315-2021.


Deriving the Dietary Approaches to Stop Hypertension (DASH) Score in Women from Seven Pregnancy Cohorts from the European ALPHABET Consortium. Aubert AM, Forhan A, de Lauzon-Guillain B, Chen LW, Polanska K, Hanke W, Jankowska A, Mensink-Bout SM, Duijts L, Suderman M, Relton CL, Crozier SR, Harvey NC, Cooper C, McAuliffe FM, Kelleher CC, Phillips CM, Heude B, Bernard JY. Nutrients. 2019 Nov 8;11(11):2706. doi: 10.3390/nu11112706.


These publications, in high impact journals, have been highlighted in press releases and invited commentaries.


The results from this series of individual participant data meta-analyses suggest that suboptimal maternal diet (low quality/pro-inflammatory diet) in pregnancy is:


i) associated with lower birth size and increased risk of delivering a small-for-gestational-age baby (n=24, 861 mother-child pairs),


ii) greater risk of late childhood overweight and obesity (n=16,295 mother-child pairs),


iii) moderate increased risk of childhood anxiety, aggression, depressive and ADHD symptoms (n= 11,870 mother-child pairs),


iv) not linearly associated with child's wheezing or asthma (n=18,326 mother-child pairs). 


4. Impact


4.1 List of publications

AuthorsTitleYear, Issue, PPPartners NumberDoiPdf
Chen L-W*, Murrin CM, Mehegan J, Kelleher CK, Phillips CM*Maternal, but not paternal or grandparental, caffeine intake is associated with childhood obesity and adiposity: The Lifeways Cross-Generation Cohort Study. 2019 109(6) 1648-165510.1093/ajcn/nqz019
Wesołowska E*, Jankowska A, Trafalska E, Kałużny P, Grzesiak M, Dominowska J, Hanke W, Calamandrei G, Polańska K*.Sociodemographic, Lifestyle, Environmental and Pregnancy-Related Determinants of Dietary Patterns during Pregnancy2019 16(5). E754doi: 10.3390/ijerph16050754.
Chen L-W*, Navarro P, Murrin CM, Mehegan J, Kelleher CK, Phillips CM*Maternal Dietary Glycemic and Insulinemic Indexes Are Not Associated with Birth Outcomes or Childhood Adiposity at 5 Years of Age in an Irish Cohort Study 2019 149(6) 1037–1046doi.org/10.1093/jn/nxz025
Chen L-W*, Fitzgerald R, Murrin CM, Mehegan J, Kelleher CK, Phillips CM*. Associations of maternal caffeine intake with birth outcomes: Results from the Lifeways Cross Generation Cohort Study2018 108(6) 1301-130810.1093/ajcn/nqy219
Curtis E*, Suderman M*, Phillips CM*, Relton C*, Harvey N*.Early‐life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project2018 43(2) 158-17310.1111/nbu.12322
Mensink-Bout SM*, van Meel ER, de Jongste JC, Voortman T, Reiss IK, De Jong NW, Jaddoe VWV, Duijts L*. Maternal and neonatal 25-hydroxyvitamin D concentrations and school-age lung function, asthma and allergy. The Generation R Study. 201910.1111/cea.13384
Hu, C., Nijsten, T., van Meel, E.R. Erler NS, Piketty C, de Jong NW, Pasmans S, de Jongste JC, Duijts L.* Eczema phenotypes and risk of allergic and respiratory conditions in school age children. doi.org/10.1186/s13601-020-0310-7
Ling-Wei Chen, Adrien M Aubert, Nitin Shivappa, Jonathan Y Bernard*, Sara M Mensink-Bout, Aisling A Geraghty , John Mehegan, Matthew Suderman*, Kinga Polanska*, Wojciech Hanke, Agnieszka Jankowska, Caroline L Relton, Sarah R Crozier, Nicholas C Harvey, Cyrus Cooper, Mark Hanson, Keith M Godfrey, Romy Gaillard, Liesbeth Duijts*, Barbara Heude*, James R Hébert , Fionnuala M McAuliffe, Cecily C Kelleher, Catherine M Phillips*Maternal dietary quality, inflammatory potential and childhood adiposity: an individual participant data pooled analysis of seven European cohorts in the ALPHABET consortium doi: 10.1186/s12916-021-01908-7.
Ling-Wei Chen, Adrien M Aubert, Nitin Shivappa, Jonathan Y Bernard*, Sara M Mensink-Bout, Aisling A Geraghty, John Mehegan, Matthew Suderman*, Kinga Polanska*, Wojciech Hanke, Elzbieta Trafalska, Caroline L Relton*, Sarah R Crozier, Nicholas C Harvey*, Cyrus Cooper, Liesbeth Duijts* Barbara Heude*, James R Hébert, Fionnuala M McAuliffe, Cecily C Kelleher, Catherine M Phillips*Associations of maternal dietary inflammatory potential and quality with offspring birth outcomes: An individual participant data pooled analysis of 7 European cohorts in the ALPHABET consortium.doi: 10.1371/journal.pmed.1003491.
Kinga Polanska*, Pawel Kaluzny, Adrien M Aubert, Jonathan Y Bernard, Liesbeth Duijts*, Hanan El Marroun, Wojciech Hanke, James R Hébert, Barbara Heude*, Agnieszka Jankowska, Giulia Mancano, Sara M Mensink-Bout, Caroline Relton*, Nitin Shivappa, Matthew Suderman*, Elzbieta Trafalska, Ewelina Wesolowska, Raquel Garcia-Esteban, Mònica Guxens, Maribel Casas, Catherine M Phillips*Dietary Quality and Dietary Inflammatory Potential During Pregnancy and Offspring Emotional and Behavioral Symptoms in Childhood: An Individual Participant Data Meta-analysis of Four European Cohortsdoi: 10.1016/j.biopsych.2020.10.008.
Sara M Mensink-Bout, Evelien R van Meel, Johan C de Jongste, Isabella Annesi-Maesano, Adrien M Aubert, Jonathan Y Bernard*, Ling-Wei Chen , Cyrus Cooper, Sarah R Crozier, Wojciech Hanke, Nicholas C Harvey*, James R Hébert, Barbara Heude*, Joanna Jerzynska, Cecily C Kelleher, John Mehegan, Fionnuala M McAuliffe, Catherine M Phillips*, Kinga Polanska*, Caroline L Relton*, Nitin Shivappa, Matthew Suderman*, Vincent W V Jaddoe, Liesbeth Duijts*Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 childrendoi: 10.1183/13993003.01315-2021.
Adrien M Aubert, Anne Forhan, Blandine de Lauzon-Guillain, Ling-Wei Chen, Kinga Polanska*, Wojciech Hanke, Agnieszka Jankowska, Sara M Mensink-Bout, Liesbeth Duijts*, Matthew Suderman*, Caroline L Relton*, Sarah R Crozier, Nicholas C Harvey*, Cyrus Cooper, Fionnuala M McAuliffe, Cecily C Kelleher, Catherine M Phillips*, Barbara Heude*. Jonathan Y Bernard*Deriving the Dietary Approaches to Stop Hypertension (DASH) Score in Women from Seven Pregnancy Cohorts from the European ALPHABET Consortiumdoi: 10.3390/nu11112706.
Lecorguillé M, Charles MA, Lepeule J, Lioret S, de Lauzon-Guillain B, Forhan A, Tost J, Suderman M*, Heude B.*Association between dietary patterns reflecting one-carbon metabolism nutrients intake before pregnancy and placental DNA methylation. doi: 10.1080/15592294.2021.1957575.
Catherine M Phillips*, Ling-Wei Chen, Barbara Heude*, Jonathan Y Bernard, Nicholas C Harvey*, Liesbeth Duijts*, Sara M Mensink-Bout, Kinga Polanska*, Giulia Mancano, Matthew Suderman,* Nitin Shivappa, James R HébertDietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review.doi: 10.3390/nu11081873
Hu C, Duijts L*, Erler NS, Elbert NJ, Piketty C, Bourdès V, Blanchet-Réthoré S, de Jongste JC, Pasmans SGMA, Felix JF, Nijsten T. Most associations of early-life environmental exposures and genetic risk factors poorly differentiate between eczema phenotypes: the Generation R Study. doi: 10.1111/bjd.17879.
Chen LW, Lyons B, Navarro P, Shivappa N, Mehegan J, Murrin CM, Hébert JR, Kelleher CC, Phillips CM*Maternal dietary inflammatory potential and quality are associated with offspring asthma risk over 10-year follow-up: the Lifeways Cross-Generation Cohort Study.10.1093/ajcn/nqz297
Marion Lecorguillé, Marie-Aline Charles, Johanna Lepeule, Sandrine Lioret, Blandine de Lauzon-Guillain, Anne Forhan, Jörg Tost, Matthew Suderman*, Barbara Heude*Association between dietary patterns reflecting one-carbon metabolism nutrients intake before pregnancy and placental DNA methylationDOI: 10.1080/15592294.2021.1957575
den Dekker HT, Burrows K, Felix JF, Salas LA, Nedeljkovic I, Yao J, Rifas-Shiman SL, Ruiz-Arenas C, Amin N, Bustamante M, DeMeo DL, Henderson AJ, Howe CG, Hivert MF, Ikram MA, de Jongste JC, Lahousse L, Mandaviya PR, van Meurs JB, Pinart M, Sharp GC, Stolk L, Uitterlinden AG, Anto JM, Litonjua AA, Breton CV, Brusselle GG, Sunyer J, Smith GD, Relton CL*, Jaddoe VWV, Duijts L*Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course. doi: 10.1183/13993003.01795-2018.
Mensink-Bout SM, Santos S, van Meel ER, Oei EHG, de Jongste JC, Jaddoe VWV, Duijts L*General and Organ Fat Assessed by Magnetic Resonance Imaging and Respiratory Outcomes in Childhood.doi: 10.1164/rccm.201905-0942OC.
Mensink-Bout SM, van Meel ER, de Jongste JC, Voortman T, Reiss IK, De Jong NW, Jaddoe VWV, Duijts L*Maternal and neonatal 25-hydroxyvitamin D concentrations and school-age lung function, asthma and allergy. The Generation R Study. doi: 10.1111/cea.13384.
Contreras ZA, Chen Z, Roumeliotaki T, Annesi-Maesano I, Baïz N, von Berg A, Bergström A, Crozier S, Duijts L*, Ekström S, Eller E, Fantini MP, Kjaer HF, Forastiere F, Gerhard B, Gori D, Harskamp-van Ginkel MW, Heinrich J, Iñiguez C, Inskip H, Keil T, Kogevinas M, Lau S, Lehmann I, Maier D, van Meel ER, Mommers M, Murcia M, Porta D, Smit HA, Standl M, Stratakis N, Sunyer J, Thijs C, Torrent M, Vrijkotte TGM, Wijga AH, Berhane K, Gilliland F, Chatzi L. DDoes early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts.doi: 10.1183/13993003.00504-2018.
Shagiwal SS, den Dekker HT, de Jongste JC, Brusselle GG, Jaddoe VWV, Felix JF, Duijts L*Influence of genetic variants on childhood lung function - The Generation R Study. doi: 10.1111/pai.12931.
van Meel ER, de Jong M, Elbert NJ, den Dekker HT, Reiss IK, de Jongste JC, Jaddoe VWV, Duijts L*Duration and exclusiveness of breastfeeding and school-age lung function and asthma. doi: 10.1016/j.anai.2017.05.002.
de Jong NW, Elbert NJ, Mensink-Bout SM, van der Valk JPM, Pasmans SGMA, Jaddoe VWV, de Jongste JC, van Wijk RG, Duijts L*Parental and child factors associated with inhalant and food allergy in a population-based prospective cohort study: the Generation R Study. doi: 10.1007/s00431-019-03441-5.

4.2 Presentation of the project

Target groupAuthorsMeans of communicationHyperlinkPdf
Scientists, public health professionals and cliniciansChen L-W*, Navarro P, Murrin CM, Mehegan J, Kelleher CK*, Phillips CM*. Prospective associations of maternal glycaemic insulin index and load with birth outcomes and weight status at age 5 years: results from the Lifeways Cross Generation Cohort Study. Public Health Science Conference, Belfast, UK, 2018Poster presentation
Scientists, nutritional professionals and policy makersChen L-W*, Fitzgerald R, Murrin CM, Mehegan J, Kelleher CK*, Phillips CM* Associations of maternal caffeine intake with birth outcomes: Results from the Lifeways Cross Generation Cohort Study. International Conference on Nutrition and Growth, Paris, France, 2018Oral presentation
Scientists, clinicians, studentsN Harvey*. Gestational vitamin D supplementation and offspring bone development: translation from observation to intervention. World Congress in the Developmental Origins of Adult Health and Disease, Rotterdam, 2017Oral presentation
Scientists, clinicians, studentsCurtis E*, Harvey N* et al., RXRA promoter DNA methylation at birth is associated with gestational vitamin D supplementation: results from the MAVIDOS trial. World Congress in the Developmental Origins of Adult Health and Disease, Rotterdam, 2017Oral presentation
Scientists, clinicians, studentsCurtis E*, Harvey N* et al, Maternal urinary beta-C-terminal telopeptide of type I collagen (CTX) in pregnancy, and response to cholecalciferol supplementation: findings from the MAVIDOS trial. World Congress in Osteoporosis, Krakow, 2018Oral presentation
Public (school children)N Harvey*, E Curtis* Bone Research Society event at annual conference (Lifelab). June 26th 2018Workshop
Scientists, clinicians, studentsH.T. den Dekker, Newborn DNA- methylation, childhood lung function, and the risk of asthma and COPD across the life course, DOHaD, Rotterdam, 2017Oral presentation
Scientists, clinicians, studentsS.M. Mensink-Bout*, Influence of maternal and fetal 25-hydroxyvitamin D levels on lung function and atopic disease development, DOHaD, Rotterdam, 2017Poster presentation
Scientists, clinicians, studentsS.M. Mensink-Bout, Vitamin D levels during pregnancy and respiratory health in childhood, International Conference on Nutrition&Growth, Paris, 2018Oral presentation
Scientists, clinicians, studentsC. Hu, Eczema phenotypes in childhood, DOHaD, Rotterdam, 2017Poster presentation
Scientists, clinicians, studentsC. Hu, Phenotypes of childhood eczema, EAACI Skin Allergy Club, 2018Oral presentation
Scientists, clinicians, studentsC. Hu, Eczema phenotypes in childhood, DOHaD, Rotterdam, 2017Poster presentation
ScientistsS.M. Mensink-Bout*, Influence of maternal and fetal 25-hydroxyvitamin D levels on lung function and atopic disease development, Conference on Epidemiological Birth Cohort and Longitudinal Studies – 3rd Paula Rantakallio Symposium, Oulu, 2018Poster presentation
Scientists, clinicians and policy makersS.M. Mensink-Bout*, Early life vitamin D levels and childhood respiratory morbidity and allergic sensitization, European Respiratory Society International Congress, Paris, 2018Oral presentation
Scientists, cliniciansC. Hu, Associations of early life environmental exposures and genetic risk factors with eczema phenotypes, Annual meeting of Dutch Society for Experimental Dermatology 2019Oral presentation
Scientists, cliniciansC. Hu, Eczema phenotypes and risk of allergic and respiratory conditions in school age children, European Society for Pediatric Dermatology Congress, 2019Oral presentation
Scientists, cliniciansC. Hu, Associations of early life environmental exposures and genetic risk factors with eczema phenotypes, European Society for Pediatric Dermatology Congress, 2019Poster presentation
Scientists, clinicians, studentsS.M. Mensink-Bout, General and organ fat measures and respiratory outcomes at the age of 10 years, Sophia Research Day, Rotterdam, 2019Oral presentation
Generation R Study participants Study participants are kept informed of updates/news from the cohort studies Newsletters (usually annual, but up to 4 times/year for Generation R) Social media including cohort websites and facebook. Press releases.
Scientists, public health professionals and cliniciansChen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, Mehegan J, Suderman M*, Polanska K*, Hanke W, Trafalska E, Relton CL*, Crozier SR, Harvey NC*, Cooper C, Duijts L*, Heude B*, Hébert JR, McAuliffe FM, Kelleher CC, Phillips CM* Influence of maternal dietary inflammatory potential and quality on offspring birth outcomes: a pooled analysis of 7 European cohorts in the ALPHABET consortium. 11th World Congress on Developmental Origins of Health and Disease, Melbourne, Australia. October 20-23, 2019.Oral
Scientists, public health professionals and cliniciansChen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, Mehegan J, Suderman M*, Polanska K, Hanke W, Jankowska A, Relton CL*, Crozier SR, Harvey NC*, Cooper C, Hanson M, Godfrey KM, Gaillard R, Duijts L*, Heude B*, Hébert JR, McAuliffe FM, Kelleher CC, Phillips CM* Maternal dietary quality, inflammatory potential and offspring adiposity throughout childhood: a pooled analysis of 7 European cohorts (ALPHABET consortium). 13th Federation of European Nutrition Societies (FENS) European Nutrition Conference 2019, Dublin, Ireland. October 15-18, 2019.Oral
Scientists, public health professionals and cliniciansChen LW, Lyons B, Navarro P, Shivappa N, Mehegan J, Murrin CM, Hébert JR, Kelleher CC, Phillips CM* Maternal Dietary Inflammatory Potential and Quality Are Associated with Offspring Asthma Risk over 10-year Follow-up: The Lifeways Cross-Generation Cohort Study. Nutrition 2019 by the American Society of Nutrition, Baltimore, USA. June 8-11, 2019
Scientists, public health professionals and cliniciansPolańska K*, Trafalska E, Hanke W, Wesołowska E, Jankowska A, Kałużny P, Janasik B, Gromadzinska J, Wasowicz W, Calamandrei G. Sociodemographic, lifestyle, environmental and pregnancy-related determinants of the micronutrients status during pregnancy. 31st annual conference of the International Society for Environmental Epidemiology (ISEE 2019) 25-28 August 2019, Utrecht, The NetherlandsOral
Scientists, public health professionals and cliniciansPolańska K*, Trafalska E, Hanke W, Wesołowska E, Jankowska A, Kałużny P, Janasik B, Gromadzinska J, Wasowicz W, Calamandrei G. Sociodemographic, lifestyle, environmental and pregnancy-related determinants of the micronutrients status during pregnancy. 12th European Public Health Conference Building bridges for solidarity and public health. 20 - 23 November 2019, Marseille, FranceOral
Scientists, public health professionals and cliniciansMatthew Suderman*. Prenatal nutrition, DNA methylation and offspring health outcomes. European Association for the Study or Obesity and the World Obesity Federation joint congress, 2020,Oral
Scientists and cliniciansE Curtis, N Harvey* MAVIDOS 4 year bone outcomes at American Society for Bone and Mineral Research Annual Scientific Meeting, Orlando, Florida, USA, September 2019.Oral
Scientists and cliniciansE Curtis*, N Harvey* MAVIDOS maternal bone turnover markers at World Congress in Osteoporosis, Paris, France, April 2019.Oral
Scientists and cliniciansE Curtis: Mechanisms of maternal and offspring bone health in MAVIDOS; UK Association of Physicians, Oxford, UK April 2019.Oral
Scientists and cliniciansN Harvey*: Developmental contribution to bone health in peak bone mass debate, 6th European Calcified Tissue Society Congress, Budapest 2019Oral

4.3 List of submitted patents and other outputs

Patent licencePartners involvedYearInternational eu or national patentCommentPdf

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