Dietary modulation of intestinal microbiota as trigger of liver health: role of bile acids

HDHL INTIMIC cofunded call “Interrelation of the Intestinal Microbiome, Diet and Health” (IM 2017)
Dietary modulation of intestinal microbiota as trigger of liver health: role of bile acids
Ina Bergheim
University of Vienna


Partner Organization Partner Country
University Clinic RWTH AachenGermany
University of ViennaAustria
University of GothenburgSweden
University of HohenheimGermany

1. Overall project description

1.1 Summary

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide.
Alterations of intestinal microbiota composition and associated impairments of intestinal
barrier function are critical in the onset and progression of NAFLD. Recent data suggest a
pivotal role of bile acids and microbial bile acid metabolism as mediators of gut-liver-crosstalk
subsequently affecting NAFLD initiation and progression. Soluble fibers like oat β-glucans
bind bile acids and modulate intestinal microbiota composition thereby affecting metabolic
parameters and liver health. Furthermore, intervention trails suggest that manipulating
intestinal microbiota composition through prebiotics may improve disease progression of
NAFLD. However, the molecular mechanisms involved remain incompletely understood and
established therapeutic strategies are still missing. The proposed project combines the
complementary expertise of 5 groups with a strong background in various aspects of diet,
liver disease, bile acids and intestinal microbiota. Through combining this expertise and
combining clinical interventions with mouse models, the project aims to determine in the
following 3 work packages (WP): Is the interaction of bile acids and intestinal microbiota
critical for the initiating (WP1 and 2) and progressing stages (WP3) of NAFLD? Can these
stages be targeted through diet and more specifically with prebiotics like oat β-glucans
thereby improving disease progression and overall health?

1.2 Highlights

4. Impact

4.1 List of publications

AuthorsTitleYear, Issue, PPPartners NumberDoiPdf

4.2 Presentation of the project

Target groupAuthorsMeans of communicationHyperlinkPdf

4.3 List of submitted patents and other outputs

Patent licencePartners involvedYearInternational eu or national patentCommentPdf

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This project has received funding from the European Union’s
H2020 Research and Innovation Programme under grant agreement n.696300

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