ALPHABET

Early life programming of childhood health: a nutritional and epigenetic investigation of adiposity and bone, cardiometabolic, neurodevelopmental and respiratory health

Project description

Background and aim

According to the Developmental Origins of Health and Disease hypothesis early life exposure to environmental factors plays a critical role in defining offspring health in childhood and later life. Thus adaptation to suboptimal nutrition during pregnancy or early childhood may perpetuate intergenerational transmission of a range of adverse health outcomes. Epigenetic phenomena have been proposed as potential mediating mechanisms. Novel associations between selected early life exposures and offspring epigenome and health have been reported. However the complexity of intergenerational whole diet-health-epigenome associations is not fully understood.

The ALPHABET project aims to address this gap. This consortium brings together 7 partners from Ireland, UK, France, The Netherlands, Poland and the US and 8 European longitudinal birth cohorts which are at the international forefront of lifecourse epidemiology.This project will allow us to go beyond the limits of individual cohorts to try to identify and validate diet-health-epigenome relationships across multiple populations. Using dietary, clinical and epigenetic data and biological samples from these cohorts, this project will advance the state-of-the-art by significantly expanding the knowledge base regarding the relationships between maternal dietary environment (defined by dietary quality and inflammatory potential), offspring health outcomes (including adiposity, bone, cardiometabolic, respiratory and neurodevelopmental health) and offspring epigenetics (DNA methylation) from birth throughout childhood.

The main objectives are to:

  1. Harmonise data from participating birth cohorts
  2. Perform epigenetic profiling of archived samples
  3. Generate dietary inflammatory indices (DII) and dietary quality scores (DASH)
  4. Determine maternal diet effects on offspring health and epigenetics
Expected impact

Given the research focus, the expected scientific, health and socio-economic impacts of the project results may be significant considering the health service and societal costs associated with obesity alone, currently and for future generations.

  • For the scientific community

Our results will make a significant contribution to the knowledge base regarding the developmental origins of health/disease, specifically highlighting the importance and increasing awareness of the role of maternal dietary quality and inflammatory potential during pregnancy in influencing both offspring birth and childhood outcomes.

  • Health-related applications or new products

Improving our understanding of the relationships between maternal nutrition, pregnancy outcome and subsequent child health may help inform public health policy and potentially development of functional foods or new dietary guidelines/recommendations. For example improved dietary quality and/or reduced pro-inflammatory dietary status achieved through revision of existing guidelines or development of new guidelines for optimal nutrition in pregnancy or development of functional foods may lead to beneficial health effects in women of reproductive years and their offspring which may have long term effects on their health into adulthood, with associated socioeconomic benefits.

Consortium

Partner Organization Partner Country
Nofer Institute of Occupational Medicine Poland
Erasmus University Rotterdam The Netherlands
National Institute of Health and Medical Research (INSERM) France
University of Bristol United Kingdom
University of Southampton United Kingdom

 

Highlights

Highlights from the ALPHABET project include the following publications:

Associations of maternal dietary inflammatory potential and quality with offspring birth outcomes: An individual participant data pooled analysis of 7 European cohorts in the ALPHABET consortium. Chen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, Mehegan J, Suderman M, Polanska K, Hanke W, Trafalska E, Relton CL, Crozier SR, Harvey NC, Cooper C, Duijts L, Heude B, Hébert JR, McAuliffe FM, Kelleher CC, Phillips CM.PLoS Med. 2021 Jan 21;18(1):e1003491. doi: 10.1371/journal.pmed.1003491.

Maternal dietary quality, inflammatory potential and childhood adiposity: an individual participant data pooled analysis of seven European cohorts in the ALPHABET consortium. Chen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, Mehegan J, Suderman M, Polanska K, Hanke W, Jankowska A, Relton CL, Crozier SR, Harvey NC, Cooper C, Hanson M, Godfrey KM, Gaillard R, Duijts L, Heude B, Hébert JR, McAuliffe FM, Kelleher CC, Phillips CM.BMC Med. 2021 Feb 22;19(1):33. doi: 10.1186/s12916-021-01908-7.

Dietary Quality and Dietary Inflammatory Potential During Pregnancy and Offspring Emotional and Behavioral Symptoms in Childhood: An Individual Participant Data Meta-analysis of Four European Cohorts. Polanska K, Kaluzny P, Aubert AM, Bernard JY, Duijts L, El Marroun H, Hanke W, Hébert JR, Heude B, Jankowska A, Mancano G, Mensink-Bout SM, Relton C, Shivappa N, Suderman M, Trafalska E, Wesolowska E, Garcia-Esteban R, Guxens M, Casas M, Phillips CM.Biol Psychiatry. 2021 Mar 15;89(6):550-559. doi: 10.1016/j.biopsych.2020.10.008.

Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children. Mensink-Bout SM, van Meel ER, de Jongste JC, Annesi-Maesano I, Aubert AM, Bernard JY, Chen LW, Cooper C, Crozier SR, Hanke W, Harvey NC, Hébert JR, Heude B, Jerzynska J, Kelleher CC, Mehegan J, McAuliffe FM, Phillips CM, Polanska K, Relton CL, Shivappa N, Suderman M, Jaddoe VWV, Duijts L. Eur Respir J. 2021 Sep 9:2101315. doi: 10.1183/13993003.01315-2021.

Deriving the Dietary Approaches to Stop Hypertension (DASH) Score in Women from Seven Pregnancy Cohorts from the European ALPHABET Consortium. Aubert AM, Forhan A, de Lauzon-Guillain B, Chen LW, Polanska K, Hanke W, Jankowska A, Mensink-Bout SM, Duijts L, Suderman M, Relton CL, Crozier SR, Harvey NC, Cooper C, McAuliffe FM, Kelleher CC, Phillips CM, Heude B, Bernard JY. Nutrients. 2019 Nov 8;11(11):2706. doi: 10.3390/nu11112706.

These publications, in high impact journals, have been highlighted in press releases and invited commentaries.

The results from this series of individual participant data meta-analyses suggest that suboptimal maternal diet (low quality/pro-inflammatory diet) in pregnancy is:

  • associated with lower birth size and increased risk of delivering a small-for-gestational-age baby (n=24, 861 mother-child pairs),
  • greater risk of late childhood overweight and obesity (n=16,295 mother-child pairs),
  • moderate increased risk of childhood anxiety, aggression, depressive and ADHD symptoms (n= 11,870 mother-child pairs),
  • not linearly associated with child's wheezing or asthma (n=18,326 mother-child pairs). 

Products

Title: Maternal, but not paternal or grandparental, caffeine intake is associated with childhood obesity and adiposity: The Lifeways Cross-Generation Cohort Study.
Author: Chen L-W*, Murrin CM, Mehegan J, Kelleher CK, Phillips CM*
Link: https://doi.org/10.1093/ajcn/nqz019
Title: Sociodemographic, Lifestyle, Environmental and Pregnancy-Related Determinants of Dietary Patterns during Pregnancy
Author: Wesołowska E*, Jankowska A, Trafalska E, Kałużny P, Grzesiak M, Dominowska J, Hanke W, Calamandrei G, Polańska K*.
Link: https://doi.org/10.3390/ijerph16050754
Title: Maternal Dietary Glycemic and Insulinemic Indexes Are Not Associated with Birth Outcomes or Childhood Adiposity at 5 Years of Age in an Irish Cohort Study
Author: Chen L-W*, Navarro P, Murrin CM, Mehegan J, Kelleher CK, Phillips CM*
Link: https://doi.org/10.1093/jn/nxz025
Title: Associations of maternal caffeine intake with birth outcomes: Results from the Lifeways Cross Generation Cohort Study
Author: Chen L-W*, Fitzgerald R, Murrin CM, Mehegan J, Kelleher CK, Phillips CM*.
Link: https://doi.org/10.1093/ajcn/nqy219
Title: Early‐life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project
Author: Curtis E*, Suderman M*, Phillips CM*, Relton C*, Harvey N*.
Link: https://doi.org/10.1111/nbu.12322
Title: Maternal and neonatal 25-hydroxyvitamin D concentrations and school-age lung function, asthma and allergy. The Generation R Study.
Author: Mensink-Bout SM*, van Meel ER, de Jongste JC, Voortman T, Reiss IK, De Jong NW, Jaddoe VWV, Duijts L*.
Link: https://doi.org/10.1111/cea.13384
Title: Eczema phenotypes and risk of allergic and respiratory conditions in school age children.
Author: Hu, C., Nijsten, T., van Meel, E.R. Erler NS, Piketty C, de Jong NW, Pasmans S, de Jongste JC, Duijts L.*
Link: https://doi.org/10.1186/s13601-020-0310-7
Title: Maternal dietary quality, inflammatory potential and childhood adiposity: an individual participant data pooled analysis of seven European cohorts in the ALPHABET consortium
Author: Ling-Wei Chen, Adrien M Aubert, Nitin Shivappa, Jonathan Y Bernard*, Sara M Mensink-Bout, Aisling A Geraghty , John Mehegan, Matthew Suderman*, Kinga Polanska*, Wojciech Hanke, Agnieszka Jankowska, Caroline L Relton, Sarah R Crozier, Nicholas C Harvey, Cyrus Cooper, Mark Hanson, Keith M Godfrey, Romy Gaillard, Liesbeth Duijts*, Barbara Heude*, James R Hébert , Fionnuala M McAuliffe, Cecily C Kelleher, Catherine M Phillips*
Link: https://doi.org/10.1186/s12916-021-01908-7
Title: Associations of maternal dietary inflammatory potential and quality with offspring birth outcomes: An individual participant data pooled analysis of 7 European cohorts in the ALPHABET consortium.
Author: Ling-Wei Chen, Adrien M Aubert, Nitin Shivappa, Jonathan Y Bernard*, Sara M Mensink-Bout, Aisling A Geraghty, John Mehegan, Matthew Suderman*, Kinga Polanska*, Wojciech Hanke, Elzbieta Trafalska, Caroline L Relton*, Sarah R Crozier, Nicholas C Harvey*, Cyrus Cooper, Liesbeth Duijts* Barbara Heude*, James R Hébert, Fionnuala M McAuliffe, Cecily C Kelleher, Catherine M Phillips*
Link: https://doi.org/10.1371/journal.pmed.1003491
Title: Dietary Quality and Dietary Inflammatory Potential During Pregnancy and Offspring Emotional and Behavioral Symptoms in Childhood: An Individual Participant Data Meta-analysis of Four European Cohorts
Author: Kinga Polanska*, Pawel Kaluzny, Adrien M Aubert, Jonathan Y Bernard, Liesbeth Duijts*, Hanan El Marroun, Wojciech Hanke, James R Hébert, Barbara Heude*, Agnieszka Jankowska, Giulia Mancano, Sara M Mensink-Bout, Caroline Relton*, Nitin Shivappa, Matthew Suderman*, Elzbieta Trafalska, Ewelina Wesolowska, Raquel Garcia-Esteban, Mònica Guxens, Maribel Casas, Catherine M Phillips*
Link: https://doi.org/10.1016/j.biopsych.2020.10.008
Title: Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children
Author: Sara M Mensink-Bout, Evelien R van Meel, Johan C de Jongste, Isabella Annesi-Maesano, Adrien M Aubert, Jonathan Y Bernard*, Ling-Wei Chen , Cyrus Cooper, Sarah R Crozier, Wojciech Hanke, Nicholas C Harvey*, James R Hébert, Barbara Heude*, Joanna Jerzynska, Cecily C Kelleher, John Mehegan, Fionnuala M McAuliffe, Catherine M Phillips*, Kinga Polanska*, Caroline L Relton*, Nitin Shivappa, Matthew Suderman*, Vincent W V Jaddoe, Liesbeth Duijts*
Link: https://doi.org/10.1183/13993003.01315-2021
Title: Deriving the Dietary Approaches to Stop Hypertension (DASH) Score in Women from Seven Pregnancy Cohorts from the European ALPHABET Consortium
Author: Adrien M Aubert, Anne Forhan, Blandine de Lauzon-Guillain, Ling-Wei Chen, Kinga Polanska*, Wojciech Hanke, Agnieszka Jankowska, Sara M Mensink-Bout, Liesbeth Duijts*, Matthew Suderman*, Caroline L Relton*, Sarah R Crozier, Nicholas C Harvey*, Cyrus Cooper, Fionnuala M McAuliffe, Cecily C Kelleher, Catherine M Phillips*, Barbara Heude*. Jonathan Y Bernard*
Link: https://doi.org/10.3390/nu11112706
Title: Association between dietary patterns reflecting one-carbon metabolism nutrients intake before pregnancy and placental DNA methylation.
Author: Lecorguillé M, Charles MA, Lepeule J, Lioret S, de Lauzon-Guillain B, Forhan A, Tost J, Suderman M*, Heude B.*
Link: https://doi.org/10.1080/15592294.2021.1957575
Title: Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review.
Author: Catherine M Phillips*, Ling-Wei Chen, Barbara Heude*, Jonathan Y Bernard, Nicholas C Harvey*, Liesbeth Duijts*, Sara M Mensink-Bout, Kinga Polanska*, Giulia Mancano, Matthew Suderman,* Nitin Shivappa, James R Hébert
Link: https://doi.org/10.3390/nu11081873
Title: Most associations of early-life environmental exposures and genetic risk factors poorly differentiate between eczema phenotypes: the Generation R Study.
Author: Hu C, Duijts L*, Erler NS, Elbert NJ, Piketty C, Bourdès V, Blanchet-Réthoré S, de Jongste JC, Pasmans SGMA, Felix JF, Nijsten T.
Link: https://doi.org/10.1111/bjd.17879
Title: Maternal dietary inflammatory potential and quality are associated with offspring asthma risk over 10-year follow-up: the Lifeways Cross-Generation Cohort Study.
Author: Chen LW, Lyons B, Navarro P, Shivappa N, Mehegan J, Murrin CM, Hébert JR, Kelleher CC, Phillips CM*
Link: https://doi.org/10.1093/ajcn/nqz297
Title: Association between dietary patterns reflecting one-carbon metabolism nutrients intake before pregnancy and placental DNA methylation
Author: Marion Lecorguillé, Marie-Aline Charles, Johanna Lepeule, Sandrine Lioret, Blandine de Lauzon-Guillain, Anne Forhan, Jörg Tost, Matthew Suderman*, Barbara Heude*
Link: https://doi.org/10.1080/15592294.2021.1957575
Title: Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course.
Author: den Dekker HT, Burrows K, Felix JF, Salas LA, Nedeljkovic I, Yao J, Rifas-Shiman SL, Ruiz-Arenas C, Amin N, Bustamante M, DeMeo DL, Henderson AJ, Howe CG, Hivert MF, Ikram MA, de Jongste JC, Lahousse L, Mandaviya PR, van Meurs JB, Pinart M, Sharp GC, Stolk L, Uitterlinden AG, Anto JM, Litonjua AA, Breton CV, Brusselle GG, Sunyer J, Smith GD, Relton CL*, Jaddoe VWV, Duijts L*
Link: https://doi.org/10.1183/13993003.01795-2018
Title: General and Organ Fat Assessed by Magnetic Resonance Imaging and Respiratory Outcomes in Childhood.
Author: Mensink-Bout SM, Santos S, van Meel ER, Oei EHG, de Jongste JC, Jaddoe VWV, Duijts L*
Link: https://pubmed.ncbi.nlm.nih.gov/31597047/
Title: Maternal and neonatal 25-hydroxyvitamin D concentrations and school-age lung function, asthma and allergy. The Generation R Study.
Author: Mensink-Bout SM, van Meel ER, de Jongste JC, Voortman T, Reiss IK, De Jong NW, Jaddoe VWV, Duijts L*
Link: https://doi.org/10.1111/cea.13384
Title: Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts.
Author: Contreras ZA, Chen Z, Roumeliotaki T, Annesi-Maesano I, Baïz N, von Berg A, Bergström A, Crozier S, Duijts L*, Ekström S, Eller E, Fantini MP, Kjaer HF, Forastiere F, Gerhard B, Gori D, Harskamp-van Ginkel MW, Heinrich J, Iñiguez C, Inskip H, Keil T, Kogevinas M, Lau S, Lehmann I, Maier D, van Meel ER, Mommers M, Murcia M, Porta D, Smit HA, Standl M, Stratakis N, Sunyer J, Thijs C, Torrent M, Vrijkotte TGM, Wijga AH, Berhane K, Gilliland F, Chatzi L. D
Link: https://doi.org/10.1183/13993003.00504-2018
Title: Influence of genetic variants on childhood lung function - The Generation R Study.
Author: Shagiwal SS, den Dekker HT, de Jongste JC, Brusselle GG, Jaddoe VWV, Felix JF, Duijts L*
Link: https://doi.org/10.1111/pai.12931
Title: Duration and exclusiveness of breastfeeding and school-age lung function and asthma.
Author: van Meel ER, de Jong M, Elbert NJ, den Dekker HT, Reiss IK, de Jongste JC, Jaddoe VWV, Duijts L*
Link: https://doi.org/10.1016/j.anai.2017.05.002
Title: Parental and child factors associated with inhalant and food allergy in a population-based prospective cohort study: the Generation R Study.
Author: de Jong NW, Elbert NJ, Mensink-Bout SM, van der Valk JPM, Pasmans SGMA, Jaddoe VWV, de Jongste JC, van Wijk RG, Duijts L*
Link: https://doi.org/10.1007/s00431-019-03441-5

Reports


Endreport

The main findings of the ALPHABET project are that suboptimal maternal diet (ie having a low quality or a pro-inflammatory diet) in pregnancy is:

  • asociated with lower birth size and increased risk of delivering a small-for-gestational-age baby (n=24, 861 mother-child pairs),
  • may adversely influence offspring body composition and risk of overweight and obesity, especialy during late childhood. (n=16,295 mother-child pairs),
  • associated with moderate increased risk of childhood anxiety, agression, depressive and ADHD symptoms (n= 11,870 mother-child pairs),
  • negatively associated with offspring bone outcomes (n=7,780 mother-child paris)
  • not linearly associated with child's wheezing or asthma (n=18,326 mother-child pairs). 
  • associated with subtle epigenetic modifications in the offspring.

This collective body of research highlights the importance of improving and promoting an overall maternal dietary pattern based on predefined criteria (specifically dietary quality and reducing dietary inflammatory potential) to optimise fetal and childhood growth, bone development, emotional and behavioural symptoms and avert adverse birth and childhood outcomes (including obesity) and associated substantial healthcare burden. These findings are of direct relevance to the aims of the JPI HDHL BioNH call  “to focus on the identification and validation of biomarkers that are modulated by diet and that indicate a change in health status and/or the risk of developing diet-related diseases” and 2) the JPI HDHL strategic goal to “change dietary patterns based on developments in food, nutritional and health sciences, and to develop evidence-based recommendations that will, together with concomitant changes in physical activity, have a major impact on improving public health, increasing the quality of life and prolonging productive life”.

Outcome

Our findings from a series of individual participant data meta-analyses suggest that suboptimal maternal diet (low quality/pro-inflammatory diet) in pregnancy is i) associated with lower birth size and increased risk of delivering a small-for-gestational-age baby (n=24, 861 mother-child pairs), ii) greater risk of late childhood overweight and obesity (n=16,295 mother-child pairs), iii) moderate increased risk of childhood anxiety, aggression, depressive and ADHD symptoms (n= 11,870 mother-child pairs), iv) negatively associated with offspring bone outcomes (n=7,780 mother-child pairs) and v) not linearly associated with child's wheezing or asthma (n=18,326 mother-child pairs), with limited evidence of maternal diet influence on epigenetics. 

Impact

Our results may have public health implications in terms of informing the development of more effective evidence-based public health strategies with an emphasis on advocating a healthy/less pro-inflammatory diet in pregnancy to optimise fetal growth, reduce obesity and attenuate development of a range of adverse childhood health outcomes.

Target group Authors Means of communication Hyperlink Pdf
Scientists, public health professionals and clinicians Chen L-W*, Navarro P, Murrin CM, Mehegan J, Kelleher CK*, Phillips CM*. Prospective associations of maternal glycaemic insulin index and load with birth outcomes and weight status at age 5 years: results from the Lifeways Cross Generation Cohort Study. Public Health Science Conference, Belfast, UK, 2018 Poster presentation    
Scientists, nutritional professionals and policy makers Chen L-W*, Fitzgerald R, Murrin CM, Mehegan J, Kelleher CK*, Phillips CM* Associations of maternal caffeine intake with birth outcomes: Results from the Lifeways Cross Generation Cohort Study. International Conference on Nutrition and Growth, Paris, France, 2018 Oral presentation    
Scientists, clinicians, students N Harvey*. Gestational vitamin D supplementation and offspring bone development: translation from observation to intervention. World Congress in the Developmental Origins of Adult Health and Disease, Rotterdam, 2017 Oral presentation    
Scientists, clinicians, students Curtis E*, Harvey N* et al., RXRA promoter DNA methylation at birth is associated with gestational vitamin D supplementation: results from the MAVIDOS trial. World Congress in the Developmental Origins of Adult Health and Disease, Rotterdam, 2017 Oral presentation    
Scientists, clinicians, students Curtis E*, Harvey N* et al, Maternal urinary beta-C-terminal telopeptide of type I collagen (CTX) in pregnancy, and response to cholecalciferol supplementation: findings from the MAVIDOS trial. World Congress in Osteoporosis, Krakow, 2018 Oral presentation    
Public (school children) N Harvey*, E Curtis* Bone Research Society event at annual conference (Lifelab). June 26th 2018 Workshop    
Scientists, clinicians, students H.T. den Dekker, Newborn DNA- methylation, childhood lung function, and the risk of asthma and COPD across the life course, DOHaD, Rotterdam, 2017 Oral presentation    
Scientists, clinicians, students S.M. Mensink-Bout*, Influence of maternal and fetal 25-hydroxyvitamin D levels on lung function and atopic disease development, DOHaD, Rotterdam, 2017 Poster presentation    
Scientists, clinicians, students S.M. Mensink-Bout, Vitamin D levels during pregnancy and respiratory health in childhood, International Conference on Nutrition&Growth, Paris, 2018 Oral presentation    
Scientists, clinicians, students C. Hu, Eczema phenotypes in childhood, DOHaD, Rotterdam, 2017 Poster presentation    
Scientists, clinicians, students C. Hu, Phenotypes of childhood eczema, EAACI Skin Allergy Club, 2018 Oral presentation    
Scientists, clinicians, students C. Hu, Eczema phenotypes in childhood, DOHaD, Rotterdam, 2017 Poster presentation    
Scientists S.M. Mensink-Bout*, Influence of maternal and fetal 25-hydroxyvitamin D levels on lung function and atopic disease development, Conference on Epidemiological Birth Cohort and Longitudinal Studies – 3rd Paula Rantakallio Symposium, Oulu, 2018 Poster presentation    
Scientists, clinicians and policy makers S.M. Mensink-Bout*, Early life vitamin D levels and childhood respiratory morbidity and allergic sensitization, European Respiratory Society International Congress, Paris, 2018 Oral presentation    
Scientists, clinicians C. Hu, Associations of early life environmental exposures and genetic risk factors with eczema phenotypes, Annual meeting of Dutch Society for Experimental Dermatology 2019 Oral presentation    
Scientists, clinicians C. Hu, Eczema phenotypes and risk of allergic and respiratory conditions in school age children, European Society for Pediatric Dermatology Congress, 2019 Oral presentation    
Scientists, clinicians C. Hu, Associations of early life environmental exposures and genetic risk factors with eczema phenotypes, European Society for Pediatric Dermatology Congress, 2019 Poster presentation    
Scientists, clinicians, students S.M. Mensink-Bout, General and organ fat measures and respiratory outcomes at the age of 10 years, Sophia Research Day, Rotterdam, 2019 Oral presentation    
Generation R Study participants Study participants are kept informed of updates/news from the cohort studies Newsletters (usually annual, but up to 4 times/year for Generation R) Social media including cohort websites and facebook. Press releases.    
Scientists, public health professionals and clinicians Chen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, Mehegan J, Suderman M*, Polanska K*, Hanke W, Trafalska E, Relton CL*, Crozier SR, Harvey NC*, Cooper C, Duijts L*, Heude B*, Hébert JR, McAuliffe FM, Kelleher CC, Phillips CM* Influence of maternal dietary inflammatory potential and quality on offspring birth outcomes: a pooled analysis of 7 European cohorts in the ALPHABET consortium. 11th World Congress on Developmental Origins of Health and Disease, Melbourne, Australia. October 20-23, 2019. Oral    
Scientists, public health professionals and clinicians Chen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, Mehegan J, Suderman M*, Polanska K, Hanke W, Jankowska A, Relton CL*, Crozier SR, Harvey NC*, Cooper C, Hanson M, Godfrey KM, Gaillard R, Duijts L*, Heude B*, Hébert JR, McAuliffe FM, Kelleher CC, Phillips CM* Maternal dietary quality, inflammatory potential and offspring adiposity throughout childhood: a pooled analysis of 7 European cohorts (ALPHABET consortium). 13th Federation of European Nutrition Societies (FENS) European Nutrition Conference 2019, Dublin, Ireland. October 15-18, 2019. Oral    
Scientists, public health professionals and clinicians Chen LW, Lyons B, Navarro P, Shivappa N, Mehegan J, Murrin CM, Hébert JR, Kelleher CC, Phillips CM* Maternal Dietary Inflammatory Potential and Quality Are Associated with Offspring Asthma Risk over 10-year Follow-up: The Lifeways Cross-Generation Cohort Study. Nutrition 2019 by the American Society of Nutrition, Baltimore, USA. June 8-11, 2019      
Scientists, public health professionals and clinicians Marion Lecorguillé, Pilar Navarro, Ling-Wei Chen, Celine Murrin, Karien Viljoen, John Mehegan, Nitin Shivappa, James R Hébert, Cecily C. Kelleher, Matthew Suderman* and Catherine M Phillips* Maternal and paternal dietary quality and dietary inflammation associations with offspring DNA methylation and epigenetic biomarkers of aging, European Public Health Conference, Dublin (online) Nov 10th-14th, 2021 Oral    
Scientists, public health professionals and clinicians Polańska K*, Trafalska E, Hanke W, Wesołowska E, Jankowska A, Kałużny P, Janasik B, Gromadzinska J, Wasowicz W, Calamandrei G. Sociodemographic, lifestyle, environmental and pregnancy-related determinants of the micronutrients status during pregnancy. 31st annual conference of the International Society for Environmental Epidemiology (ISEE 2019) 25-28 August 2019, Utrecht, The Netherlands Oral    
Scientists, public health professionals and clinicians Polańska K*, Trafalska E, Hanke W, Wesołowska E, Jankowska A, Kałużny P, Janasik B, Gromadzinska J, Wasowicz W, Calamandrei G. Sociodemographic, lifestyle, environmental and pregnancy-related determinants of the micronutrients status during pregnancy. 12th European Public Health Conference Building bridges for solidarity and public health. 20 - 23 November 2019, Marseille, France Oral    
Scientists, public health professionals and clinicians Matthew Suderman*. Prenatal nutrition, DNA methylation and offspring health outcomes. European Association for the Study or Obesity and the World Obesity Federation joint congress, 2020, Oral    
Scientists and clinicians E Curtis, N Harvey* MAVIDOS 4 year bone outcomes at American Society for Bone and Mineral Research Annual Scientific Meeting, Orlando, Florida, USA, September 2019. Oral    
Scientists and clinicians E Curtis*, N Harvey* MAVIDOS maternal bone turnover markers at World Congress in Osteoporosis, Paris, France, April 2019. Oral    
Scientists and clinicians E Curtis: Mechanisms of maternal and offspring bone health in MAVIDOS; UK Association of Physicians, Oxford, UK April 2019. Oral    
Scientists and clinicians N Harvey*: Developmental contribution to bone health in peak bone mass debate, 6th European Calcified Tissue Society Congress, Budapest 2019 Oral    

Subjects

Features

Project number:
ALPHABET
Duration: 100%
Duration: 100 %
2017
2021
Related subsidy round:
Project lead and secretary:
Dr Catherine Phillips