CABALA_Diet & Health

CirculAting Bile Acids as biomarkers of metabolic health - Linking microbiotA, Diet and Health

Background and aim

Bile acids (BA) through G protein-coupled bile acid receptor 1 (GPBAR1 or TGR5) and nuclear receptors like Farnesoid X receptor (FXR) regulate mammalian inflammation, and lipid, glucose, energy, and xenobiotic metabolism. The gut microbiota modulates the enterohepatic circulation of BA and microbially produced secondary BA appear to be more potent receptor agonists than primary BA, providing a mechanistic link between microbiome structure/function and regulation of host physiology. Evidence mainly from animal studies shows that dietary fibers and polyphenols and exercise can impact on BA metabolism. Similarly, certain bile salt hydrolysing (BSH) bacteria modulate circulating bile acid (CBA) profiles and strongly influence cholesterol uptake. However, human data confirming dietary modulation of CBA profiles and subsequent regulation of physiological homeostasis remains elusive. Using samples from the RoCAV cohort and existing randomised control trials (RCT), we correlated CBA profiles with Mediterranean (MED) diet adherence and measures of metabolic health. In a bespoke short-term RCT we measured the effect of Limosilactobacillus reuteri NCIMB 30242 (BSH positive probiotic), oats (prebiotics) and  Renetta Canada apples (polyphenol rich) on CBA and demonstrated that L. reuteri could increase host postprandial unconjugated and hydrophobic CBA profiles, and that oats and apples may modulate cardiovascular disease (CVD) risk markers in both chronic and acute settings. In a long term (18 month), large-scale (n=300) existing dietary and lifestyle intervention, we demonstrated how a polyphenol rich green-MED diet and exercise promotes metabolic health in prediabetics through modulation of the gut microbiota and CBA signalling (DIRECT-PLUS study). Finally, we  modelled BA profiles or metabotype with microbiome signatures and BA biotransformation potential using high-resolution metagenomics and established the molecular basis of BA regulation of immune and metabolic homeostasis by measuring the relative receptor activation potential of individual CBA and BA-metabotype profiles using novel pre-clinical human cell-based reporter systems. CABALA_diet&health has provided direct evidence in humans that CBA profiles influence CVD risk supporting their consideration as biomarkers of health, related to the microbiome and modulated by diet and exercise. We have also demonstrated in humans, that autholgous faecal microbiome transfer, after green-MED dietary intervention retards weight regain and maintains metabolic health. Moreover, we propose that global BA species diversity may be an indicator of health and bile acid convergence a function of disease, and additionally, that lowering total CBA concentrations may be a viable target for improving metabolic health at the population level

Expected impact
  • Scientific Impact.

CABALA_DIET&HEALTH aimed to improve our understanding of the fundamental link between nutrition and CBA profiles, key signalling molecules considered to be involved in regulating host metabolic and immune homeostasis, and potential biomarkers of health status. We believe this improved understanding will unravel a rational scientific basis for healthy eating guidelines, providing the European consumer the opportunity to make informed choices when building their diets from a variety of foods. It will provide the European food industry with key knowledge on how specific food ingredients regulate BA profiles and identify new targets to improve the foods we eat. Finally, we believe it will also deliver health care providers with a validated biomarker of the long-term trajectory from health to chronic diet/life-style associated disease. Our project will maximise the knowledge and investment from existing initiatives for example RoCAV cohort, and create synergies with relevant initiatives in particular the JPI Biomarker projects FOODBALL, SALIVAGES and VALID which members of this consortium are directly linked or where collaborations have been formed during the present project. This project also provided a multidisciplinary, trans-omics and inter-sector training for early stage researchers, thereby supporting European scientific/clinical/industrial research infrastructure. This will ensure that a critical mass will be achieved which will contribute to the JPI’s vision of improving public health through dietary strategies and a more informed society.

  • Health-related applications and/or new products

CABALA_diet&health has the potential to provide the scientific mechanistic data linking key components of the Mediterranean style diet, and healthy eating guidelines across Europe. Specifically, we show that intake of foods rich in fermentable fibers, polyphenols and probiotics, can modulate circulating bile acid profiles and impact on metabolic health. The project contributes the scientific support for rational selection of probiotics and other functional ingredients, which can then be incorporated into new foods to improve metabolic health at the population level. The project also supports existing whole foods and diets already rich in fibers and polyphenols, also supporting existing healthy eating guidelines. The aim is to improve adherence to healthy diets by promoting consumption of fiber/polyphenol/probiotic rich foods and providing the scientific basis for designing new foods. 


Partner Organization Partner Country
University Of Reading United kingdom
University College Cork Ireland
University of Insubria Italy


Diet-microbe-gut health dialogue centers on bile acid (BA) activation of signaling receptors in dictating both metabolic and health status.  Our work indicates global diversity as an indicator of health, bile acid convergence is a function of disease. In Cork Ireland, we have determined, through cellular systems, signaling and gene expression overlap along with independence of process between three bile acid receptors (FXR, VDR, TGR5), functionally and regionally.  Finally, bile acids are emulsifiers of lipid.  Our work has shown that lipids can act as a sequesterants of certain bile acids negating their signaling effects, at the level of gene expression and cell organelle fitness.

We have demonstrated, in a bespoke mixed chronic and acute postprandial challenge dietary intervention conducted in Reading UK, that functional foods specifically, oats (prebiotic), polyphenol rich apples (Renetta Canada apples) and a BSH positive probiotic, (Limosilactobacillus reuteri NCIMB 30242), can influence post prandial circulating BA (CBA) profiles on an individual basis but may mediate their respective health effects via different mechanisms, especially during the postprandial phase. Apples reduced fasting apoB, a marker of low-density lipoprotein cholesterol (an independent CVD risk factor), and both oats and apples influenced postprandial glycaemic control and triacylglycerol response.  L. reuteri had a significant effect on postprandial secondary CBA concentrations. 

From the RoCAV cohort study in Varese Italy, we confirmed that diet was associated with CBA profiles, which were in turn associated with metabolic health. Specifically, high levels of CBA were associated with unhealthy metabolic parameters, whereas high levels of the BA responsive hormone FGF-19 was confirmed to be associated with reduced HOMA index and waist-to-hip ratio. 

In the DIRECT-PLUS dietary intervention with a polyphenol enriched Mediterranean diet conducted at the Ben Gurion University of the Negev in Israel, 6 month weight loss could be directly attributed to dietary microbiota modulation. Moreover, total CBA concentrations positively correlated with metabolic disease risk factors and autochthonous faecal microbiome transplant (aFMT) after green-MED diet microbiome modulation retarded weight regain over an 8 month follow up and maintained metabolic health.  

Strong correlations between individual CBA species or ratios with individual bacterial taxa were rare within the datasets and not consistent between different studies. Correlations between CBA profiles and enterotype-like community structures were apparent but not conserved across different data-sets. Microbial BA metabolism may therefore be more correctly considered as a community activity, possibly with different taxa performing similar chemical conversions in different individuals. Shotgun and strain level analysis did not resolve CBA:taxa associations but revealed relatively low prevalence and abundance of BA metabolizing genes across samples, suggesting a gap in knowledge concerning annotation of microbial BA metabolising genes.


Title: 4th Microbiome R&D and Business Collaboration Forum, and Probiotics Congress, April 3-4, 2017, Amsterdam, The Netherlands
Author: Duc H. Le
Title: Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism.
Author: Golubeva AV, Joyce SA, Moloney G, Burokas A, Sherwin E, Arboleya S, Flynn I, Khochanskiy D, Moya-Pérez A, Peterson V, Rea K, Murphy K, Makarova O, Buravkov S, Hyland NP, Stanton C, Clarke G, Gahan CGM, Dinan TG, Cryan JF.
Title: Connecting the immune system, systemic chronic inflammation and the gut microbiome: The role of sex
Author: Rizzetto L, Fava F, Tuohy KM, Selmi C.
Title: Isotopic dilution method for bile acid profiling reveals new sulfate glycine-conjugated dihydroxy bile acids and glucuronide bile acids in serum.
Author: Ulaszewska MM, Mancini A, Garcia-Aloy M, Del Bubba M, Tuohy KM, Vrhovsek U.
Title: Gut microbiota and health: connecting actors across the metabolic system.
Author: Fava F, Rizzetto L, Tuohy KM.
Title: Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection
Author: Mullish BH, McDonald JAK, Pechlivanis A, Allegretti JR, Kao D, Barker GF, Kapila D, Petrof EO, Joyce SA, Gahan CGM, Glegola-Madejska I, Williams HRT, Holmes E, Clarke TB, Thursz MR, Marchesi JR
Title: Two apples a day lower serum cholesterol and improve cardiometabolic biomarkers in mildly hypercholesterolemic adults: a randomized, controlled, crossover trial.
Author: Koutsos, A, Riccadonna, S, Ulaszewska, MM, Franceschi, P, Trošt, K, Galvin, A, Braune, T, Fava, F, Perenzoni, D, Mattivi, F, Tuohy, KM, Lovegrove, J.
Title: The effect of autologous fecal microbiota transplantation on weight loss regain.
Author: Ehud Rinott*, Ilan Youngster, , Anat Yaskolka Meir, Gal Tsaban, Hila Zelicha, Alon Kaplan, Dan Knights, Kieran Tuohy*, Francesca Fava*, Matthias Uwe Scholz*, Oren Ziv, Elad Reuven, Amir Tirosh, Assaf Rudich, Matthias Blüher, Michael Stumvoll, Uta Ceglarek, Karine Clement, Omry Koren, Dong D. Wang, Frank B. Hu, Meir J Stampfer, Iris Shai.
Title: Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial
Author: Anat Yaskolka Meir,1 Ehud Rinott*,1 Gal Tsaban,1,2 Hila Zelicha,1 Alon Kaplan,1 Philip Rosen,3 Ilan Shelef,3 Ilan Youngster,4 Aryeh Shalev,2 Matthias Blüher,5 Uta Ceglarek,6 Michael Stumvoll,5 Kieran Tuohy *,7 Camilla Diotallevi *,7,8 Urska Vrhovsek*,8 Frank Hu,9,10,11 Meir Stampfer,9,10,11 Iris Shai
Title: Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation
Author: Mastrocola R*, Collotta D*, Gaudioso G*, Le Berre M*, Cento AS*, Ferreira Alves G*, Chiazza F*, Verta R*, Bertocchi I*, Manig F*, Hellwig M*, Fava F*, Cifani C*, Aragno M*, Henle T*, Joshi L*, Tuohy K*, Collino M*.
Title: Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice
Author: Collotta D, Hull W, Mastrocola R, Chiazza F, Cento AS, Murphy C, Verta R, Alves GF, Gaudioso G, Fava F, Yaqoob M, Aragno M, Tuohy K, Thiemermann C, Collino M.
Title: Identification of dietary patterns in a general population of North Italian adults and their association with arterial stiffness. The RoCAV study
Author: Lasalvia P, Gianfagna F, Veronesi G, Franchin M, Tozzi M, Castelli P, Grandi AM, Zambon A, Iacoviello L, Ferrario MM.
Title: Genotypic and phenotypic characterization of food-associated Lactobacillus plantarum isolates for potential probiotic activities
Author: Prete R, Long SL, Joyce SA, Corsetti A.
Title: Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system
Author: Geng W, Long SL, Chang YJ, Saxton AM, Joyce SA, Lin J.
Title: Beneficial bile acid metabolism from Lactobacillus plantarum of food origin
Author: Prete R, Long SL, Gallardo AL, Gahan CG, Corsetti A, Joyce SA.
Title: Two apples a day modulate human:microbiome co-metabolic processing of polyphenols, tyrosine and tryptophan
Author: Ulaszewska MM, Koutsos A, Trošt K, Stanstrup J, Garcia-Aloy M, Scholz M, Fava F, Natella F, Scaccini C, Vrhovsek U, Tuohy K, Lovegrove J, Mattivi F.
Title: Measuring the effect of Mankai® (Wolffia globosa) on the gut microbiota and its metabolic output using an in vitro colon model
Author: Camilla Diotallevi, Giulia Gaudioso, Francesca Fava, Andrea Angeli, Cesare Lotti, Urska Vrhovsek, Ehud Rinott, Iris Shai, Marco Gobbetti, Kieran Tuohy
Title: Circulating bile acids as a link between the gut microbiota and cardiovascular health: impact of prebiotics, probiotics and polyphenol-rich foods
Author: Rose-Anna G. Pushpass*, Shouq Alzoufairi*, Kim G. Jackson* and Julie A. Lovegrove*
Title: The Cholesterol-Lowering Effect of Oats and Oat Beta Glucan: Modes of Action and Potential Role of Bile Acids and the Microbiome
Author: Joyce SA, Kamil A, Fleige L, Gahan CGM.
Title: Bile Acids as Receptor Ligands in Metabolic Processes - The FXR Connection
Author: Sarah Louise Long* and Susan A. Joyce*
Title: Concentrations of fecal bile acids in participants with functional gut disorders and healthy controls.
Author: Shanalee C James, Karl Fraser, Wayne Young, Phoebe E Heenan, Richard B Gearry, Jacqueline I Keenan, Nicholas J Talley, Susan A Joyce, Warren C McNabb, Nicole C Roy



CABALA_DIET&HEALTH aimed to demonstrate that diet-microbiome interactions in the gut determine circulating bile acid (CBA) profiles and their physiological effects. Our overarching objective was to provide evidence in humans, that CBA may be considered modifiable biomarkers of cardiovascular or metabolic health and disease risk, which are determined by the gut microbiota and respond to diet and life-style intervention. The project has published new analytical methodologies, analyzed data and samples from existing/ongoing studies, including the DIRECT-PLUS study in Israel, developed new pre-clinical in vitro models for measuring CBA cell signaling and completed the CABALA_diet&health dietary intervention study in Reading, UK. It has also generated new models correlating CBA with gut microbiota composition (FEM, USDI), with dietary intake, exercise and with clinical markers of cardiovascular disease (CVD) risk. It has demonstrated that diet, both in chronic and acute postprandial settings influence CBA profiles and that total CBA concentrations and profiles of CBA are inversely related with specific CVD risk biomarkers at a population level (RoCAV study, Varese Italy). CABALA_diet&health has demonstrated and developed new cell based reporter systems at UCC, Ireland, which confirm that different CBA and profiles of CBA can regulate host physiological processes involved in inflammatory and metabolic pathways which govern CVD and metabolic disease risk and moreover, we have shown that major perturbation of the gut microbiota, via diet (DIRECT-PLUS green-MED diet), surgery (three different common bariatric surgeries) and autologous faecal microbiome transplant (aFMT) can modulate CBA, biomarkers of CVD risk and body weight in humans. From our observations we can also propose that global BA species diversity is associated with metabolic and immune health, and that reduced diversity is associated with inflammatory related disease. This project, therefore, has provided strong evidence in humans, that CBA concentrations may be a biomarker of health, modified by diet, exercise and the gut microbiota. It has also provided support that microbiota BA metabolism may play an important mechanistic role in mediating the health effects of the Mediterranean style diet and bioactive foods including oats, apples and probiotics (Limosilactobacillus reuteri NCIMB 30242 ). Further, we have provided new evidence in humans, that the gut microbiota and its BA metabolism, may be an active driver of diet induced weight management, retreat of diabetes upon surgery and major dietary intervention, and that aFMT of a green-MED diet modified microbiome can reduce the risk of weight regain and metabolic rebound following successful diet induced weight loss. Together, data from the CABALA_diet&health projects support the notion that the gut microbiota is not a passive by-stander in obesity and metabolic disease, but an active player in metabolic health. Furthermore, we have also shown that diet and medical interventions known to reduce body weight and improve markers of metabolic disease risk do so in part through their interactions with the gut microbiota and that microbial BA metabolism contributes mechanistically to metabolic health across Domains of life. 

CABALA_diet&health therefore provides fundamental new insights into how diet, through the gut microbiota, can shape metabolic and inflammatory related chronic disease risk. This supports JPI-HDHL efforts to tackle the societal challenge of nutrition and health. Specifically, by demonstrating that total CBA concentrations and  profiles are related to CVD markers, we provide supportive human observational data of their health biomarker status. By demonstrating that foods and diet, especially healthy high polyphenol diets can regulate total CBA in the long term (DIRECT-PLUS study) and postprandially on an individual basis, we provide support for population level interventions with foods and diets rich in polyphenols and fiber and providescientific support for existing healthy eating guidelines based on the Mediterranean style diet. Similarly, by demonstrating that the gut microbiome, which regulates both the size of the BA pool systemically and the profile of individual BA species in circulation and in faeces, contributes directly to weight loss and improved metabolic health (DIRECT-PLUS ), we provide new supportive data in humans, that microbiome targeted strategies have significant potential to tackle the global burden of overweight, obesity and the diseases of obesity. Healthy dietary guidelines, especially those targeting metabolic and cardiovascular disease, are well established throughout the world but translation to individual lifestyles remains a challenge. Part of the problem is lack of mechanistic understanding of how healthy foods and diets translate into physiological effects in the human body. This has challenged medical uptake of nutrition as an efficacious intervention or even preventative strategy, and left room for confused and contradictory messaging in the general media, contributing to poor uptake of healthy diets at the population level. Similarly, without sound scientific basis of how healthy foods regulate host physiology, the food industry has struggled to provide nutritious foods to serve the challenges of modern lifestyles. However, foods and medical intervention strategies for shaping the gut microbiota are well established, and by providing new insight into how microbiome modulation can shape CBA profiles and total concentrations, and concomitantly influence host physiology, CABALA_diet&health has contributed significantly to providing a rational basis for designing the next generation of functional foods. Future work should help fill gaps in nutrient:nutrient interactions in the gut and how they influence the gut microbiome and BA metabolism; new bioinformatics tools to link new or dual function microbial enzymes to specific chemical reactions in BA metabolism, and a more personalized, genotype based approach towards CBA:BA receptor interactions; and broader application of nutri-kinetics based approaches to demonstrating how foods and diets modulate microbially derived metabolites capable of regulating human metabolic and inflammatory pathways and shown in animal studies to determine chronic disease risk and immune-resilience in the face of pathogen invasion.


Communication & Dissemination Activities

Target groupAuthorsMeans of communicationLink
ScientistsJulie Lovegrove, The CABALA diet & health study at University of Reading, Consortium kick-off meeting, London, 2017Presentation 
Scientists, studentsCamilla Pedersen, The CABALA diet & health study, Hugh Sinclair Unit of Human Nutrition, University of Reading, 2017Presentation 
ScientistsButhaina Alathari, The CABALA diet & health study at University of Reading, JPI HDHL Conference, Brussels/Belgium, 2017Presentation 
Scientists, students, general public (volunteers)Buthaina Alathari, The Effect of Probiotic, Prebiotic, and Polyphenol Intake on Platelet Function – CABALA Diet and Health, Hugh Sinclair PhD symposium, University of Reading, 2018Presentation 
ScientistsKieran Tuohy, Samantha Riccadona, Lisa Rizzetto, Francesca Fava, Introducing CABALA diet & health and related existing studies, Consortium kick-off meeting, London, 2017Presentation 
ScientistsKieran Tuohy, Lisa Rizzetto, EUREGIO-EFA project (including descritption of CABALA_diet&health and possibilities for collaboration), 2nd EUREGIO-EFA scientific working group meeting. Hall, Austria, 2018Presentation, workshop 
ScientistsMarynka Ulaszewska. “FEM contribution WP 5.4, FOODBALL” Annual FoodBall Project Meeting in Varna (Bulgaria), 31 August-1 September 2017Presentation, workshop 
General publicKieran Tuohy, “Of men and microbes” – measuring how diet:microbe interactions in the gut can reduce chronic disease risk”; International Economic Festival, Trento, Italy, 2017Presentation 
General publicIris Shai “What is the actual effects of MED diet on mobilization of human fat storage pools & cardio- metabolic health? Evidence from long-term clinical trials”. International Economic Festival, Trento, Italy, 2017Presentation 
Undergraduate students (nutrition)Kieran Tuohy, “A role for polyphenols in shaping the structure and function of the gut microbiome.” University of Ulster, Coleraine, UK. 2017Lecture Presentation 
Scientists, Medical doctorsKieran Tuohy “Gut microbiota composition, bile acid signalling and human health: CABALA_Diet&Health”. 9th Probiotics, Prebiotics, New Foods conference, Rome, Italy, 2017Presentation 
Medical doctorsKieran Tuohy, “Microbiota-diet interactions in neurodegeneration, and in Parkinson’s disease”. The selection and management of advanced therapies in the Parkinson's disease in specialist centers (National Medical Conference on Parkinsons), Rovereto, Italy, 2018Presentation 
Scientists, IndustryKieran Tuohy “Probiotic reverse engineering – choose your mechanism first then your strain”. 4th Microbiome R&D and Business Collaboration Forum: Europe and Probiotics Congress: Europe. Amsterdam, 2017.Presentation 
Scientists, Industry,Kieran Tuohy, “Microbiome Modulation for Improved Metabolic Health.” ILSI-Taiwan Annual meeting & Scientific Symposium, Taipei, 2018Presentation 
Scientists, IndustryKieran Tuohy “ILSI Europe activities related to ‘Human Microbiome & Health”. ILSI-Europe annual Meeting, Brussels, 2017Presentation 
Scientists, Medical doctorsKieran Tuohy, “The gut microbiota and human health - a molecular cross-talk”. European Medical Association Annual Conference, London 2017Presentation 
General public, Medical doctorsKieran Tuohy, “The gut microbiota and human health - a molecular cross-talk”. European Medical Association Annual Conference, London 2017 Video 
Medical doctors, ScientistsKieran Tuohy “Microbiota and fat tissue distribution”. Diabesità. Pisa, Italy, 2017Presentation 
ScientistsKieran Tuohy “Gut microbiota functions: metabolism of nutrients and other food components.” POSITIVe Cost action meeting, Thessaloniki, 2017Presentation 
General PublicAndrea Manchini, Francesca Fava, Kieran Tuohy, Siamo Europa Festival, 2018. Open-showcase of regional scientific projects funded by the EU, 3 day event, face-to-face meet the public.Meet the public face to face 
Scientists, IndustryKieran Tuohy ILSI Europe Functional Foods Task force meeting, May 2018. ‘Microbiome Modulation for Improved Metabolic Health’. Brussels, 2018Presentation 
General publicAlimentary Adventures- Western Gateway building UCC Spring Open Day- 17th May 2017Meet the public face to face 
Scientists /studentsOrganiser APC-ICL Postgraduate Symposium October 2017 (SLL)Presentation 
Students teachersAll Ireland Schools of Pharmacy Conference (April 2017), Cork, Ireland: Impact of gut microbiota-mediated bile acid metabolism on the solubilization capacity of bile salt micelles and drug biopharmaceutical properties.Presentation 
General publicScience for All Public forum and competition -finalist (April 2017), Cork, Ireland: Gut bacteria and medicines: “bugging” you to keep your health “afloat”.Presentation 
General publicOctober 2017 An evening of Food at the Cornstore restaurant, Cork spoke to general public on the dietary components they were consuming and the microbes associated with fermented foodsPresentation 
Students TeachersJune 2017 School representative at open days for entry students, CorkMeeting face to face 
Academics & stakeholders & general publicTuohy, K. FOOD2030, PLOVDIV, Side event 6: Food in Regions – one health, from regionality to functionality. Date 13th June 2018, Venue: Sankt Petersburg Hotel, Plovdiv (BG)Presentation 
Students, academics & stakeholdersKieran Tuohy, “Host:microbe cross talk in metabolic disease and healthy ageing - potential for dietary manipulation”, METAORGANISMS, MICROBIAL BIOREFINERIES AND HUMAN HEALTH, Fondazione Golinelli – Bologna, 18-19 June 2018.PresentationDOWNLOAD 
Academic & stakeholdersKieran Tuohy, “Microbiome and ageing – dietary microbiome modulation for improved mental and physical quality of life in old age”, at ‘Nutrition for the Ageing Brain: Moving Towards Clinical Applications’ Madrid, Spain 30– 31/08/2018Presentation 
Academics, students, stakeholders & dieticiansKieran Tuohy, “The Prebiotic Effects of Whole-Grain Oats”, European Federation of the Associations of Dietitians Conference in Rotterdam, The Netherlands 28th-29thSeptember, 2018. Quaker SymposiumPresentation 
Academics, students & stakeholdersKieran Tuohy, “Diet:Microbe interactions in the gut for improved health – talking molecules”, Microbiome R&D and Business Collaboration Forum: Europe, 20th to 22nd May, 2019Presentation 
Academics, students & stakeholdersKieran Tuohy, “Diet:Microbe interactions in the gut– talking molecules”, Free University of Bolzano, From Bread, Cheese and Wine Sciences to Processing and Tasting, Free University of Bozen-Bolzano Room A2.2.32 at NOI Techpark 18 — 19 June 2019PresentationDOWNLOAD 
General publicUCC, November 2017 A series of back to back talks on Diet, microbes and health at Cork City GaolPresentation 
General publicUCC, International Womens day interview for twitter and Facebook -6th March 2018Twitter/facebook 
General publicUoR BBC4 Interview with Adrian Washbourne BBC Radio Science Unit 10th January 2018 broadcast as part of a four part documentary series in April 2018.Radio interview 
Students & academicsDoctoral Research Conference 2019 University of Reading Film Contest - Vlog of the CABALA diet and health study by Shouq Alzoufairi (PhD student) submitted 29th April 2019Engagement focused website, blog or social media channel 
Students & academicsPresentation in the UoR Food and Nutrition Science (FNS) weekly seminar, University of Reading, 22nd May 2019 - The effect of probiotic, prebiotic and polyphenol interventions on biomarkers of cardiometabolic health. Shouq Alzoufairi (PhD student)Presentation 
Students & academicsJPI HDHL Science Vlog Contest - Vlog of the CABALA diet and health study by Dr Rose-Anna Pushpass and Shouq Alzoufairi (PhD student) February 20th 2019Engagement focused website, blog or social media channel 
Students & academicsPresentation in the FNS Research Symposium, University of Reading, 21st February 2019 - The effect of probiotic, prebiotic and polyphenol interventions on biomarkers of cardiometabolic health. Shouq Alzoufairi (PhD student)Presentation 
Students & academicsPresentation at research group meeting of UoR Nutrition Research Group: Update on the CABALA study presented by Dr Rose-Anna PushpassPresentation 
Medicinal and specialist foods industryKieran Tuohy, Dr Schar ( ), presentation including CABALA_diet&health, July 19th 2018, Trieste.Presentation 
Food/confectionary industry & Ferraro MSc students in nutritionKieran Tuohy, “The Gut Microbiota in health and disease - role of diet”, Ferraro and Ferraro MSc in Food and Human Nutrition, University of Turin, January 18th 2019.Presentation 
Scientific community, JPI HDHL communityAll CABALA_diet&health partners, Kieran Tuohy FEM presenting as coordinator, JPI-HDHL final conference 27th October 2020.Oral presentationDOWNLOAD 
European nutrition societies, nutrition scientists, dieticians, medical experts, international food industryKieran Tuohy, 3th European Nutrition Conference, Federation of European Nutrition Societies (FENS) Dublin, Ireland. 15 – 18 October 2019. side event organized by ILSI EuropeOral presentationDOWNLOAD 
European nutrition societies, nutrition scientists, dieticians, medical experts, international food industryKieran Tuohy, 3th European Nutrition Conference, Federation of European Nutrition Societies (FENS) Dublin, Ireland. 15 – 18 October 2019. Side event organized by Quaker OatsOral presentationDOWNLOAD 
International / American nutrition community, food scientists, dieticians, medical experts, microbiome expertsKieran Tuohy, American Society for Nutrition annual convention, Nutrition 2020 Live Online, Pepsico organised "Healthy Microbiome Session", 1-4 June 2020.Oral presentationDOWNLOAD 
International (Japan) scientific community, food scientists, nutritionists, dieticians, medical experts, metabolomics expertsKieran Tuohy, International Conference on Polyphenols and Health 28 Nov - 01 Dec 2019 Kobe International Conference Center, Kobe, JapanOrla presentationDOWNLOAD 
International (Israeli) scientific community, food scientists, food engineers, nutritionists, dieticians, medical expertsKieran Tuohy, invited lecture, Technion, Hypha, Israel, December 16th 2020, online.Oral presentaitonDOWNLOAD 
International scientific community (Florida, USA), University of South FloridaKieran Tuohy, invited lecture, Microbiome Club, University of South Florida. 16th June 2021.Oral presentationDOWNLOAD 
Scientific community, analytical chemistry, metabolomics, food scienceSusan Joyce and UCC team, Irish Mass Spectrometry Meeting May 20211 post doc presentation, 4 posters 
Scientific Community, microbiologySusan Joyce, Microbiology Society Ireland and UK April 2021Keynote lecture 
Scientific and medical communitySusan Joyce, University College Cork Medical Research and Technology conference November 2020Invited lecture/speech 
International scientific community, microbiome, microbiology, medical research communitiesSusan Joyce, 8th Microbiome Research and Development Industry Conference November 2020Keynote speaker, oral presentation 
International scientific community, gut microbiome, microbiology, medical research communitiesAnirudh Jaisimha, Speaker APC Virtual Symposium on Non-communicable diseases and antimicrobial resistance, APC Microbiome IrelandInvited speaker, oral presentation 
International scientific community, biochemistry, analytical chemistrySusan Joyce, Irish Mass Spectrometry Meeting May 2019Invited speaker, oral presentation 
International scientific community, medical researchers, microbiology, gut microbiome communitiesSusan Joyce, Infection and Immunity Microbiome Symposium Bristol April 2019Keynote speaker, oral presentation 
Scientific community, biochemistry, food science, nutrition, gut microbiome, human health communitiesSusan Joyce, Cost action Nutredox Conference October 2019, LisbonInvited speaker, Oral communication 
Scientific community, probiotics, prebiotics, gut microbiota, nutrition, human health, international nutraceutical industry,Susan Joyce, The International Scientific Conference on Probiotics and Prebiotics 2018 BudapestInvited speaker, oral presentation 
International scientific community, gut microbiome, nutrition, human healthSusan Joyce, Keystone Symposium, Canada 2018Keynote lecture, oral presentationDOWNLOAD 
International scientific community, medical and gastroenterology ocmmunitiesSusan Joyce, World Congress in Gastroenterology Rome, Italy 2018Keynote speaker, oral presentation 
International scientific community, gut microbiome, functional foods, probiotics, prebiotics, international food/nutraceutical industrySusan Joyce and the UCC team, 7th International Human Microbiome Conference Kerry 201810 Posters; 3rd prize of 300 posters 
International scientific community, gut health, biochemistry, nutrition, gastroenterologySusan Joyce and the UCC team, XXV International Bile Acid Meeting: Bile Acids in Health and Disease 2018 Conference 6th to 7th July 2018 Dublin, Ireland2 posters 
International scientific community, gut microbiome, human healthy and disease risk, microbiologySusan Joyce, Exploring Human Host-Microbiome Interactions in Health and Disease 05–07 December 2018 Wellcome Genome Campus, UK DOWNLOAD 
General public - dissemination on gut microbiota in human health and diseaseUCC team, SAJ Interviewed by James Gallagher and recorded part thereof “Second genome” -recording and Pod cast- award winning series of BBCRadio4 Downloads >6.5 million Aired: 24 April 2018Radio,LINK
General publicSusan Joyce UCC Cornstore Restaurant Limerick: Lay audience talks: Food for thought June 2019Oral pesentation 
General publicSusan Joyce, UCC Cornstore Restaurant Cork: Lay audience talks: Love your Gut June 2018Oral presentation 
General publicAnirudh Jaisimha UCC, Pint of Science Cork September 2020Oral presentation 
University educationSarah Long UCC, Responsible for Transition year student Jan 2019  
 Sarah Long UCC, Cork Summer Agricultural Show –gut matters – information stand June 2018Oral presentation 
 Buthaina AlAthari (UoR PhD Student), 4th International Conference of JPI HDHL - Introduction to CABALA study. February 2018.Oral presentation 
 Dr Camilla Pedersen (UoR) ,A talk or presentation - Presentation at research group meeting Introduction to the CABALA study presented. February 2018.Oral presentation 
 Julie Lovegrove (UoF), British Nutrition Foundation (BNF) Webinar on Prebiotics ‘Prebiotics in our diet’. Professor 13th Dec 2018Webinar 
Nutrition research communityJulie Lovegrove, (UoR) Invited presentation in the Winter Nutrition Society conference, Royal Society of Medicine, London, 4-5 December 2018: Optimal diet and lifestyle strategies for the management of cardio-metabolic risk. Title of presentation: Dietary Dilemmas over Fats and Cardiovascular Disease Risk. December 2018.Oral presentaiton 
General public/international stakeholdersJulie Lovegrove (UoR) Kuwait Embassy, Cultural Visit. ‘Research in the Hugh Sinclair Unit of Human Nutrition’. Reading, UK. 12th Feb 2019.Oral presentation 
Nutrition communityJulie Lovegrove, British Nutrition Foundation Task Force Report launch ‘Human gut microbiome: a new frontier for CVD’ London, UK, 27th Feb 2019.Oral presentation 
Education - staff, students University of NevarraAngeles Moron Ortiz (MSc placement student) UoR: A talk or presentation - Presentation for the University of Nevarra MSc viva, 11th September 2019 – Circulating Bile Acids As Biomarkers of Metabolic Health – Analysis of the Impact of Different Diets on Body Composition, Food Intake, Blood Pressure and Gastrointestinal Symptoms, September 2019.Oral presentation 
Nutrition research communityShouq Alzoufairi (PhD student), UoR: A talk or presentation - Presentation in the FNS Research Symposium, University of Reading, 5th November 2019 - The effect of probiotic, prebiotic and polyphenol interventions on biomarkers of cardiometabolic health.Orla presentation 
 Julie Lovegrove UoR: Interview on Radio Berkshire and Talk Talk radio, 20th December 2019 - Two apples a day lower serum cholesterol and improve cardiometabolic biomarkers in mildly hypercholesterolemic adults/Introducing the CABALA study. December 2019.A press release, press conference or response to a media enquiry/interview - 
 Julie Lovegrove, UoR: A talk or presentation - Invited presentation at International conference. 13th Federation European Nutrition Societies (FENS) meeting. “Dietary bioactives and cardiovascular Health” Dublin, Ireland. March 2020.Oral presentation 
 Julie Lovegrove, UoR: A talk or presentation - Invited Keynote presentations at International conference on Chronic Diseases and Lifestyle. Presentation entitled ‘Diet and Cardiovascular Disease Risk’. Lahore, Pakistan.March 2020.Oral presentation 
Nutrition research communityShouq Alzoufairi (PhD Student), UoR: at the Nutrition Society Summer Meeting 2021. Presentation entitled ‘The effect of probiotic, prebiotic, and polyphenol interventions on cardiometabolic disease risk markers: findings from the CABALA study’ virtual meeting. July 2021.A talk or presentation - Poster presentation 
 Rose-Anna Pushpass, UoR: Nutrition Society Summer Meeting 2021. Presentation entitled ‘The effect of probiotic, prebiotic and polyphenol interventions on gut hormones and markers of glycaemic control: findings from the CABALA study’ virtual meeting. July 2021.A talk or presentation - Poster presentation 



Project number:
CABALA_Diet & Health
Duration: 100%
Duration: 100 %
Related funding round:
Project lead and secretary:
Kieran Tuohy