DERiVE
DEvelopment of Riboflavin biomarkers to relate dietary sources with status, gene-nutrient Interactions and Validated health Effects in adult cohorts
Background and aim
Sub-optimal status of Riboflavin (vitamin-B2) may be more widespread than generally recognised because of reliance on dietary data only in many nutrition surveys and lack of reliable biomarker data. The DERiVE project aimed to address this by developing accessible riboflavin biomarkers and by demonstrating important functional, gene-nutrient and health effects of optimal riboflavin status in Canadian, Irish and UK cohorts. The objectives of the project were to:
•.develop accessible biomarkers for assessment of riboflavin status and identify which most sensitively reflected dietary riboflavin intake in Irish (n=1136) and Canadian (1200) adults;
• determine which of the newly developed riboflavin-biomarkers were in best agreement with the gold-standard functional biomarker, erythrocyte glutathione reductase activation co-efficient (EGRac);
• investigate the functional significance of B2 by investigating whether low riboflavin status affects the riboflavin (FMN)-dependent generation of active vitamin B6;
• confirm the role of riboflavin in modulating blood pressure, via a novel gene-nutrient interactive effect, in UK, Irish and Canadian populations.
Summary of the main findings
- Using a newly validated high-throughput method for assessment of riboflavin status, results indicate that plasma riboflavin:
- is the most promising measure of status (of three biomarkers investigated; plasma riboflavin, FMN and FAD).
- has the predictive power to identify individuals with low riboflavin (EGRac >1.3) or deficient riboflavin status (EGRac >1.4). Plasma FMN and FAD had no predictive capacity.
- EGRac analysis found 56% of Canadians had optimal riboflavin status while 24% were deficient compared with 38% (optimal) v 35% (deficient) in NANS. Plasma riboflavin analysis further validated these findings in Canadians v NANS (19.0 v 13.9 vs nmol/L). 18% of Irish adults reported inadequate riboflavin intake while the main dietary sources of riboflavin were milk (20–24%), meat & meat products (14–18%) and ready-to-eat breakfast cereals (6–14%).
- In UK and Irish cohorts those with optimal riboflavin status had significantly higher B6 status compared to those with deficient riboflavin status, confirming the metabolic dependency of vitamin B6 on riboflavin status. B6 status was significantly lower in Canadian women with riboflavin deficiency compared to adequacy.
- The role of riboflavin in modulating blood pressure, via a novel gene-nutrient interactive effect, was confirmed in UK and Irish cohorts; analysis of Canadian data is underway.
Expected impacts
The findings have important public health implications. Suboptimal riboflavin status is more widespread than generally recognised and is associated with adverse health outcomes. The validation of a low-cost, high-throughput method for biomarker assessment of riboflavin will enable important data to be generated to inform future policies aimed at promoting better health globally.
Consortium
| Partner Organization | Partner Country |
|---|---|
|
Ulster University |
Northern Ireland, UK |
| University College Cork | Ireland |
| University of British Colombia | Canada |
Highlights
Published article, 2019:
In conjunction with its sister project - ‘VALID’ (both funded under the same JPI ERA-HDHL 2017 co-funded call "Biomarkers for Nutrition and Health"), - an IMPACT article co-written by the two Project Coordinators, Prof Mary Ward and Prof Helene McNulty was published to profile the DERiVE and VALID projects. Impact 2018 (10): 1-4. doi: 10.21820/23987073.2018.10.83. This publication, highlighting both JPI HDHL projects, has been disseminated widely to a wide range of stakeholders internationally and through project websites: www.jpi-valid.com and www.derive-riboflavn.com.
12th International Conference on One Carbon Metabolism, B Vitamins and Homocysteine, Reus, Spain in June 2019
Members of the DERiVE team attended the 12th International Conference on One Carbon Metabolism, B Vitamins and Homocysteine, Reus, Spain in June 2019. Dr Liadhan McAnena’s presentation 'Is riboflavin deficiency in women of reproductive age a global problem?' was very well received by conference delegates and generated much discussion. The main findings were that sub-optimal riboflavin status in both developed and developing countries, appears to be a much greater problem that is generally recognised. Young women, particularly those in low-middle income countries, appear to be at greatest risk of riboflavin deficiency. The health consequences of low and deficient riboflavin across different populations (particularly in relation to hypertension and cardiovascular disease) are the focus of ongoing analysis.
International Event, Dublin Ireland, 2019
The consortia for the DERiVE and VALID projects co-hosted a scientific symposium of both JPI HDHL projects at the Federation of European Nutrition Societies (FENS) 13th European Nutrition Conference, Dublin, Ireland, 15-18 October 2019, entitled 'Validating novel biomarkers of dietary exposure to Riboflavin and Polyphenols and associated health impacts: Transnational DERiVE and VALID projects'. At this joint symposium, Prof Mary Ward (DERIVE PI, Ulster University) presented ‘The metabolic interaction of the B-vitamins riboflavin and vitamin B6 within one-carbon metabolismin European adult cohorts – The DERiVE project’. Observational data (>5000 adults aged 18-102) were accessed from two large cohorts (the Trinity Ulster Department of Agriculture, TUDA study conducted in NI and ROI and the Irish National Adult and Nutrition, NANS Survey in ROI). Results confirmed a strong metabolic interdependency between riboflavin and vitamin B6 across adulthood and provided evidence that riboflavin is an important determinant of vitamin B6 status across the lifecycle. Work is ongoing to investigate the functional effects of changes in riboflavin status by measuring the response of vitamin B6 biomarker to interventions with riboflavin. Prof Yvonne Lamers (DERiVE project co-investigator and PI from University of British Columbia, Canada) presented ‘Validation of biomarkers to assess riboflavin status in Irish and Canadian population cohorts: the DERiVE project’ which confirmed plasma riboflavin as a reliable direct marker of riboflavin status for use in population studies. The symposium was very well received and generated a high degree of active participation from the scientific audience comprised of FENS conference delegates.
Products
Title: Riboflavin, MTHFR genotype and blood pressure: A personalized approach to prevention and treatment of blood pressure
Author: McNulty H*, Strain JJ*, Hughes CF, Ward M*
Link: https://doi.org/10.1016/j.mam.2016.10.002
Author: McNulty H*, Strain JJ*, Hughes CF, Ward M*
Link: https://doi.org/10.1016/j.mam.2016.10.002
Title: Riboflavin is an important determinant of vitamin B-6 status in healthy adults
Author: McNulty H, Ward M, Strain JJ, McAnena L, Pentieva K
Link: https://doi.org/10.1093/jn/nxaa225
Author: McNulty H, Ward M, Strain JJ, McAnena L, Pentieva K
Link: https://doi.org/10.1093/jn/nxaa225
Title: Blood pressure and hypertension in relation to cognitive performance in older Irish adults from the TUDA cohort: Preliminary analysis.
Author: Jarrett H*, Moore K, Hughes CF, Porter K, Hoey L, Ward M*, Strain JJ*, Molloy AM, Cunningham C, Casey M, Laird E, McCarroll K, Pentieva K*, McNulty H*
Author: Jarrett H*, Moore K, Hughes CF, Porter K, Hoey L, Ward M*, Strain JJ*, Molloy AM, Cunningham C, Casey M, Laird E, McCarroll K, Pentieva K*, McNulty H*
Title: Nutritional challenges for older adults in Europe: current status and future directions
Author: Kehoe L*, Walton J*, Flynn A*
Link: https://doi.org/10.1017/S0029665118002744
Author: Kehoe L*, Walton J*, Flynn A*
Link: https://doi.org/10.1017/S0029665118002744
Title: Association of key sources of riboflavin with EGRac status in a representative sample of Irish adults aged 18–90 years.
Author: Kehoe L*, Walton J*, Hopkins S, McNulty B, Nugent AP, McNulty H*, Ward M*, Flynn A*
Link: https://doi.org/10.1017/S0029665119000405
Author: Kehoe L*, Walton J*, Hopkins S, McNulty B, Nugent AP, McNulty H*, Ward M*, Flynn A*
Link: https://doi.org/10.1017/S0029665119000405
Title: Intake, status and dietary sources of riboflavin in a representative sample of Irish adults aged 18-90 years.
Author: Kehoe L*, Walton J*, Hopkins S, McNulty B, Nugent AP, McNulty H*, Ward M*, Flynn A*
Link: https://doi.org/10.1017/S0029665118000708
Author: Kehoe L*, Walton J*, Hopkins S, McNulty B, Nugent AP, McNulty H*, Ward M*, Flynn A*
Link: https://doi.org/10.1017/S0029665118000708
Title: Dairy foods and cardiovascular health: a review of current evidence
Author: Ward M* and McNulty H*
Link: https://doi.org/10.1093/advances/nmab118
Author: Ward M* and McNulty H*
Link: https://doi.org/10.1093/advances/nmab118
Title: Approaches to improving micronutrient status assessment at the population level
Author: Lamers Y*
Link: https://doi.org/10.1017/S0029665118002781
Author: Lamers Y*
Link: https://doi.org/10.1017/S0029665118002781
Title: Assessing biomarker status of vitamin B in the laboratory: no simple solution
Author: Hughes CF and McNulty H*
Link: https://doi.org/10.1177/0004563217747907
Author: Hughes CF and McNulty H*
Link: https://doi.org/10.1177/0004563217747907
Title: Impact article on nutritional biomarkers for health
Author: Ward M* and McNulty H*
Link: https://doi.org/10.3390%2Fnu11051092
Author: Ward M* and McNulty H*
Link: https://doi.org/10.3390%2Fnu11051092
Title: Blood pressure profile and impact of MTHFR genotype in adults aged 60 to 102 years: preliminary findings.
Author: Psara E, Moore K, Ward M*, Hughes CF, Strain JJ*, Molloy AM, ... McNulty M*
Link: https://doi.org/10.1017/S0029665118000630
Author: Psara E, Moore K, Ward M*, Hughes CF, Strain JJ*, Molloy AM, ... McNulty M*
Link: https://doi.org/10.1017/S0029665118000630
Title: Addressing optimal folate and related B-vitamin status through the lifecycle: health impacts and challenges
Author: McNulty H*, Ward M*, Hoey L, Hughes CF, Pentieva K*
Link: https://doi.org/10.1017/s0029665119000661
Author: McNulty H*, Ward M*, Hoey L, Hughes CF, Pentieva K*
Link: https://doi.org/10.1017/s0029665119000661
Title: Evidence of a role for one-carbon metabolism in blood pressure: can B vitamin intervention address the genetic risk of hypertension owing to a common folate polymorphism?
Author: McNulty H*, Strain JJ*, Hughes CF, Pentieva K*, Ward M*
Link: https://doi.org/10.1093/cdn/nzz102
Author: McNulty H*, Strain JJ*, Hughes CF, Pentieva K*, Ward M*
Link: https://doi.org/10.1093/cdn/nzz102
Title: Critical review of nutrition, blood pressure and risk of hypertension through the lifecycle: do B vitamins play a role?
Author: Psara E, Pentieva K*, Ward M*, McNulty H*
Link: https://doi.org/10.1016/j.biochi.2020.03.016
Author: Psara E, Pentieva K*, Ward M*, McNulty H*
Link: https://doi.org/10.1016/j.biochi.2020.03.016
Title: Riboflavin supplementation alters global and gene-specific DNA methylation in adults with the MTHFR TT genotype
Author: Amenyah SD, McMahon A, Ward M*, Deane J, McNulty H*, Hughes CF, Strain JJ*, Horigan G, Purvis J, Walsh CP, Lees-Murdock DJ
Link: https://doi.org/10.1016/j.biochi.2020.04.007
Author: Amenyah SD, McMahon A, Ward M*, Deane J, McNulty H*, Hughes CF, Strain JJ*, Horigan G, Purvis J, Walsh CP, Lees-Murdock DJ
Link: https://doi.org/10.1016/j.biochi.2020.04.007
Title: Impact of the MTHFR C677T polymorphism on one-carbon metabolites: Evidence from a randomised trial of riboflavin supplementation
Author: Rooney M*, Bottiglieri T, Wasek-Patterson B, McMahon A, Hughes CF, McCann A, Horigan G, Strain JJ*, McNulty H*, Ward M*
Link: https://doi.org/10.1016/j.biochi.2020.04.004
Author: Rooney M*, Bottiglieri T, Wasek-Patterson B, McMahon A, Hughes CF, McCann A, Horigan G, Strain JJ*, McNulty H*, Ward M*
Link: https://doi.org/10.1016/j.biochi.2020.04.004
Title: Measures of vascular health in a cohort of healthy adults stratified by MTHFR genotype
Author: Rooney M*, Hughes CF, McNulty H*, Clements M, Strain JJ*, Ward M*
Link: http://dx.doi.org/10.1038/s41371-018-0109-3
Author: Rooney M*, Hughes CF, McNulty H*, Clements M, Strain JJ*, Ward M*
Link: http://dx.doi.org/10.1038/s41371-018-0109-3
Title: Influence of nutrients involved in one-carbon metabolism on DNA methylation in adults - a systematic review and meta-analysis
Author: Amenyah SD, Hughes CF, Ward M*, Rosborough S, Deane J, Thursby S-J, Walsh CP, Kok DEG, Strain JJ*, McNulty H*, Lees-Murdock DJ
Link: https://doi.org/10.1093/nutrit/nuz094
Author: Amenyah SD, Hughes CF, Ward M*, Rosborough S, Deane J, Thursby S-J, Walsh CP, Kok DEG, Strain JJ*, McNulty H*, Lees-Murdock DJ
Link: https://doi.org/10.1093/nutrit/nuz094
Title: Intakes and status of riboflavin in a representative sample of Irish adults aged 18–90 years screened for MTHFR C677T polymorphism
Author: O'Sullivan E*, Kehoe L*, Walton J*, McNulty H*, Ward M*, McAnena L*, Hopkins S.M., McNulty B.A, Nugent A.P. and Flynn A*
Link: http://dx.doi.org/10.1017/S0029665120000191
Author: O'Sullivan E*, Kehoe L*, Walton J*, McNulty H*, Ward M*, McAnena L*, Hopkins S.M., McNulty B.A, Nugent A.P. and Flynn A*
Link: http://dx.doi.org/10.1017/S0029665120000191
Title: Plasma riboflavin concentration as novel indicator for vitamin-B2 status assessment: suggested cutoffs and its association with vitamin-B6 status in women
Author: Tan A, Zubair M, Ho C-L, McAnena L, McNulty H, Ward M and Lamers Y
Link: http://dx.doi.org/10.1017/S0029665120006072
Author: Tan A, Zubair M, Ho C-L, McAnena L, McNulty H, Ward M and Lamers Y
Link: http://dx.doi.org/10.1017/S0029665120006072
Title: The role of fortified foods and nutritional supplements in the diets of older Irish adults
Author: Laura Kehoe (a1), Janette Walton (a2), Breige A. McNulty (a3), Anne P. Nugent (a4) and Albert Flynn
Link: https://doi.org/10.1007/s00394-016-1171-7
Author: Laura Kehoe (a1), Janette Walton (a2), Breige A. McNulty (a3), Anne P. Nugent (a4) and Albert Flynn
Link: https://doi.org/10.1007/s00394-016-1171-7
Reports
Endreport
- Plasma riboflavin appears to be a reliable and accessible measure of riboflavin status for use in population cohorts. Future population studies reporting riboflavin status should include reliable accessible biomarkers rather than relying on dietary riboflavin intake only.
- Using the gold standard biomarker of riboflavin status (EGRac), 24% of Canadian and 35% of Irish adults were reported to have deficient riboflavin status while 20% of Canadians and 37% of Irish adults had sub-optimal status. Population differences are likely to be explained by differences in micronutrient enrichment / fortification policies and highlight the impact of mandatory riboflavin enrichment of flour in Canada.
- In UK, Irish and Canadian cohorts those with optimal riboflavin status had significantly higher B6 compared to those with deficient riboflavin status, confirming the metabolic dependency of vitamin B6 on riboflavin status.
- The role of riboflavin in modulating blood pressure, via a novel gene-nutrient interactive effect, was confirmed in UK and Irish cohorts; analysis of Canadian data is underway. These findings highlight the potential for optimal riboflavin status as a personalised approach to preventing / managing elevated blood pressure in adults with a common risk factor for hypertension, who represent approximately 10% of adults globally and up to 30% in some populations. Future studies are required to confirm these findings and to investigate the effect of intervention with riboflavin in different population cohorts.
How does the research contribute to the HDHL objectives
- The DERiVE project contributed to the JPI HDHL objectives by identifying and validating an accessible riboflavin biomarker (plasma riboflavin) that is modulated by diet and reflects riboflavin status in different populations.
- DERiVE provided further novel evidence that suboptimal riboflavin status, in adults with a common genetic risk factor for hypertension, was associated with higher blood pressure thus, optimising riboflavin status offers a personalised approach to managing blood pressure in at-risk adults, who represent as many as 30% in some populations globally.
- The project, which built on previous work by the project partners, brought together a trans-national collaboration, representing the UK, Ireland and Canada, who accessed existing bio-banked blood samples and data from the Irish National Adult Nutrition Survey (www.iuna.net) as well as bio-banked specimen and data from the BC Generations Project (www.bcgenerationsproject.ca) to dress the novel aims of this project.
- Further dissemination of the findings, through scientific presentations and publications are planned by the team.
Communication & Dissemination Activities
| Target group | Authors | Means of communication |
|---|---|---|
| Scientific and Professional practitioners - October 2019 | Amy Tan (UBC), 'Plasma riboflavin concentration as novel indicator for vitamin-B2 assessment: suggested cutoffs and its association with vitamin-B6 status in women', FENS 13th European Nutrition Conference, Dublin, Ireland, 14-18 October 2019 | Poster presentation |
| Scientific and Professional practitioners - October 2019 | Prof Mary Ward (UU), DERiVE-VALID Symposium chairperson, 'The metabolic interaction of the B-vitamins riboflavin and vitamin B6 within one-carbon metabolism in European adult cohorts - The DERiVE Project', FENS 13th European Nutrition Conference, Dublin, Ireland, 14-18 October 2019 | Oral presentation |
| Scientific and Professional practitioners - October 2019 | Prof Yvonne Lamers (UBC), 'Validation of biomarkers to assess riboflavin status in Irish and Canadian population cohorts: The DERiVE Project', FENS 13th European Nutrition Conference, Dublin, Ireland, 14-18 October 2019 | Oral presentation |
| Scientific | Prof Mary Ward and Prof Sean JJ Strain, Members of the Organising Committee at the FENS 13th European Nutrition Conference, Dublin, Ireland, October 2019 | Organising committee |
| Scientific and Professional practitioners - October 2019 | Dr Emma O'Sullivan (UCC), 'Intakes and status of riboflavin in a representative sample of Irish adults aged 18-90 years screened for the MTHFR C677T polymorphism', FENS 13th European Nutrition Conference, Dublin, Ireland, 14-18 October 2019 | Oral presentation |
| Scientific and Professional practitioners - October 2019 | Dr Laura Kehoe (UCC), 'The role of fortified foods and nutritional supplements in the diets of older Irish adults', FENS 13th European Nutrition Conference, Dublin, Ireland, 14-18 October 2019 | Oral presentation |
| Scientific and Professional practitioners - October 2019 | Dr Laura Kehoe (UCC), 'Nutritional challenges for older adults in Europe: current status and future directions', FENS 13th European Nutrition Conference, Dublin, Ireland, 14-18 October 2019 | Oral presentation |
| Scientific and Professional practitioners - October 2019 | Larisse Melo (UBC), 'Development of novel vitamin B12 fortified yogurts using isolated and microencapsulated vitamin B12', FENS 13th European Nutrition Conference, Dublin, Ireland 14-18 October 2019 | Poster presentation |
| Scientific and students - February 2020 | Harry Jarrett (UU), 'The metabolic interaction between riboflavin & vitamin B6 in European adults', The Nutrition Society Irish Section Postgraduate Conference, Dublin, Ireland, 12-14 February 2020 | Oral presentation |
| Industry - May 2019 | Mr Harry Jarrett (PhD Researcher) ‘The metabolic interaction between riboflavin & vitamin B6 in European adults’. DSM‐Ulster Symposium, Coleraine, Northern Ireland, 20th May 2019 | Oral presentation |
| General public - September 2019 | Prof Albert Flynn & Dr Janette Walton (UCC), 'National Children's Food Survey II: Launch of summary findings', Dublin, Ireland, 11 September 2019 | Oral presentation |
| Scientific - October 2019 | Prof Helene McNulty (UU), Co-chair of the Executive Committee, FENS 13th European Nutrition Conference, Dublin, Ireland, 14-18 October 2019 | Oral presentation at the Opening Ceremony |
| Scientific - September 2018 | Mr Harry Jarrett (PhD Researcher) ‘Blood pressure and hypertension in relation to cognitive performance in older Irish adults from the TUDA cohort: Preliminary analysis.’ British and Irish Hypertension Society (BIHS) Annual Scientific Meeting, Univeristy of Cambridge, England 24-26th September 2018 | Poster presentation |
| Scientific - July 2018 | Mr Harry Jarrett (PhD Researcher) ‘Brain function response using magnetoencephalography (MEG) to a 2 year randomised trial with B-vitamins: a pilot study’. IACC Inauguration Symposium, Cellular coenzymes in health and disease, University College London, England 2nd-3rd July 2018 | Poster presentation |
| Scientific - June 2018 | Dr Laura Kehoe (PhD Researcher) ‘Intake, status and dietary sources of riboflavin in a representative sample of Irish adults aged 18-90 years’. Nutrition Society (Irish Section) Conference 2018: Targeted approaches to tackling current nutritional issues. Ulster University, 20-22nd June 2018 | Poster presentation |
| Scientific - December 2018 | Dr Laura Kehoe (PhD Researcher) 'Association of key sources of riboflavin with EGRac status in a representative sample of Irish adults aged 18–90 years'. Nutrition Society Winter Meeting, London, December 2018 | Oral presentation |
| Scientific - June 2018 | Dr Laura Kehoe (PhD Researcher) ‘Nutritional challenges for older adults in Europe: current status and future directions’. Nutrition Society (Irish Section) Conference 2018: Targeted approaches to tackling current nutritional issues. Ulster University, 20-22nd June 2018 | Oral presentation |
| Scientific - June 2018 | Prof Yvonne Lamers 'Approaches to improving micronutrient status assessment at a population level'. Nutrition Society (Irish Section) Conference 2018: Targeted approaches to tackling current nutritional issues. Ulster University, 20-22nd June 2018 | Oral presentation |
| Scientific - June 2019 | Prof Yvonne Lamers 'From possible inadequacy to excess - discrepancy in folate status and folic acid intake of pregnant women across countries and supplementation guidelines'. 12th International conference on One Carbon Metabolism, B Vitamins and Homocysteine, Spain, 9th - 13th June 2019 | Oral presentation |
| Scientific - July 2018 | Prof JJ Strain 'DERiVE update: ERA-HDHL: Biomarkers in Nutrition and Health: ERA-HDHL mid-term symposium, The Hague, 4-5th July 2018 | Oral presentation |
| Industry - May 2019 | Dr Liadhan McAnena 'Is riboflavin deficiency in women of reproductive age a global problem?' DSM-Ulster Symposium, Coleraine, Northern Ireland, 20th May 2019 | Oral presentation |
| Scientific - June 2019 | Dr Liadhan McAnena ‘Is riboflavin deficiency in women of reproductive age a global problem?’ 12th International Conference on One Carbon Metabolism, B Vitamins and Homocysteine: Understanding their role in health and disease from the womb to old age, Southern Catalonia, Spain 9th-13th June 2019 | Poster presentation |
| Scientfic - June 2019 | Prof Helene McNulty 'Achieving optimal folate status for health: natural food folates versus folic acid', 12th International conference on One Carbon Metabolism, B Vitamins and Homocysteine, Spain, 9th - 13th June 2019 | Oral presentation |
| Scientific - August 2018 | Prof Helene McNulty 'Vitamins and Wellbeing from Tomb to Womb: Relationship between riboflavin MTHFR and hypertension'. 5th International Vitamin Conference, Sydney, Australia; 2018 | Oral presentation |
| Scientific, Industry - 2018 | Prof Helene McNulty: 'Role of nutrition throughout the lifespan: How to translate science into public health interventions at critical stages of the lifespan'. DSM symposium, Switzerland; 2018 | Oral presentation |
| Scientific - August 2018 | Prof Helene McNulty 'Riboflavin status, MTHFR and blood pressure'. Federation of American Societies for Experimental Biology (FASEB) Conference, Nova Scotia, Canada, August 2018 | Oral presentation |
| Scientific - June 2018 | Prof Helene McNulty 'Folate and related B vitamins through the lifecycle: public health priorities and challenges.' Nutrition Society (Irish Section) Conference 2018: Targeted approaches to tackling current nutritional issues. Ulster University, 20-22nd June 2018 | Oral presentation |
| Professional practitioners - 2018 | Prof Helene McNulty 'The role of riboflavin in reducing blood pressure in genetically at risk hypertensive adults'. EuroPrevent Satellite Symposium, 2018 | Oral presentation |
| Scientific - August 2018 | Dr Nadia Moran-Garcia 'Riboflavin, vitamin B6, and related metabolites detected in plasma in a single LC-MS/MS platform'. Federation of American Societies for Experimental Biology (FASEB) Conference, Nova Scotia, Canada; 2018 | Oral presentation |
| Professionals | Prof Mary Ward; Deputy Director of The Wellcome Trust-Wolfson Northern Ireland Clinical Research Facility (NICRF). Strategic role with the aim of facilitating research partnerships and collaborative between Ulster University, Queens University Belfast and The Belfast Trust. This also involves working closely with a range of other stakeholders including service users: 2017-present | A formal working group |
| Scientific - April 2019 | Prof Mary Ward 'Dairy foods and blood pressure: a review of current evidence', The Dairy Council for NI - Nutrition & Health What’s New Conference | Oral presentation |
| Study participants or study members - 2018 | Blood pressure update for RIBOGENE participants: 90 adults (participants and their family/friends) attended one of three public events held at venues across Northern Ireland (Belfast, Coleraine and Derry) to receive an update on research being conducted at the Nutrition Innovation Centre for Food and Health investigating the association between B-vitamins, blood pressure and a common genetic risk factor affecting 12% of the population. The event included 2 short presentations followed by a lively question and answer session. All those who attended provided very positive feedback following the event; 2018 | Oral presentation |
| Scientific - February 2019 | DERiVE scientific video log at the 5th International JPI HDHL conference: https://www.youtube.com/watch?v=YMPmjX4oh4o | Video log (vlog) |
| Professional Practitioners,Public/other audiences,Industry/Business,Supporters,Undergradua te students,Postgraduate students,Other audiences,Study participants or study members,Patients, carers and/or patient groups,Third sector organisations - ongoing | DERiVE Project webpage derive-rivoflavin.com | Website |
| Professional Practitioners,Public/other audiences,Industry/Business,Supporters,Undergradua te students,Postgraduate students,Other audiences,Study participants or study members,Patients, carers and/or patient groups,Third sector organisations - ongoing | DERIVE Project twitter account: @derive_1 | Twitter website |