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- Identification and validation of integrative biomarkers of physical activity level and health in children and adolescents Image AbstractPhysical activity (PA) provides health benefits across the lifespan and improves many established cardiovascular risk factors that have a significant impact on overall mortality…
- Understanding how diet modifies cognitive ageing represents the next frontiers for developing prevention strategies. A key may rely on elucidating the exact combination of dietary bioactives capable of modulating cognitive decline via brain plasticity, a major compensatory mechanism to maintain cognitive function. Another important question is the sensitive population in which such nutritional…
- Increasing evidence suggests that several non-communicable diseases, including obesity and its associated metabolic disorders, are inherited from parents to offspring over several generations by non-genetic mechanisms.In this context, it has been suggested that parental environmental cues might induce epigenetic modifications in the germ line, which are transmitted to the progeny. Hence…
- Exploring the effects of time-restricted feeding on the immune function of obese individuals: a multi-omic approach Image AbstractPathological conditions associated with unbalanced nutrient handling, such as obesity, are associated with maladapted immune responses that lead to increased susceptibility to…
- The DINAMIC project investigates the interplay between diet, the gut microbiota, and the host in the context of cardiometabolic health. Using state-of-the-art prospective human cohorts, microbiota profiling allows the consortium to identify specific features associated with disease states. Clinical trials based on dietary interventions and fecal microbiota transplantation were designed and are…
- Background and aimHEALTHMARK investigated the complex associations between diet, microbiota, tryptophan metabolites of microbial metabolism, and metabolic health in a set-up of identification, replication, and validation of associations. The project, organized in five work packages (WP) comprised two observational and two intervention studies.In WP1, the University of Bonn (UB) using the DOrtmund…
- Prevention of unhealthy weight gain in families in pregnancy and postpartum using a mHealth-enhanced intervention Image AbstractThe overall objective is to prevent unhealthy weight gain and body composition during pregnancy and in the postpartum period in vulnerable families (e.g., families…
