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- Pregnancy and infancy are critical periods for nutritional programming of metabolic health. Epigenetic changes such as DNA methylation seem to have a crucial role linking early-life nutrition to metabolic health across the life course. The aim of NutriPROGRAM was to identify early-life nutrition-related factors and related epigenetic pathways leading to metabolic adaptations and disease across the…
- Low or imbalanced dietary and biomarker status of folate and interrelated B-vitamins (methyl donor nutrients) perturb 1-carbon metabolism, and adversely affect brain development in early life and brain function in later life. The biological mechanisms explaining these relationships are not clear but may involve DNA methylation of epigenetically-controlled genes related to brain development and…
- Cardiovascular and metabolic diseases are a primary cause of morbidity and mortality worldwide. Diet is a major risk factor for cardio-metabolic health, but is challenging to study in part because metabolic response to diet is highly individualised. Characterising the molecular pathways that mediate personalised responses to diet is critical to effectively tackle the current epidemic. Epigenetic…
- Cumulative evidence suggests that food allergy (FA) is associated with a multitude of environmental factors including hygiene habits, antibiotic use, lifestyle changes and, in particular, diet. Changes in nutrition can result in dysbiosis of the skin, gut, and lung microbiota and generate changes in microbial the metabolites produced, which may in turn produce epigenetic modifications. Current…
- Sulfur amino acids, energy metabolism and obesity Image AbstractResearch over the last decade suggests that methionine and cysteine, two dietary sulfur amino acids that are abundant in proteins from animal sources, play a role in development of obesity and related metabolic diseases. In rodents, experiments with diets low in…
- Food phytochemicals matter for cardiometabolic health Image AbstractFOODPHYT aims at raising awareness and understanding of the enormous potential of food phytochemicals to support the global fight against obesity and associated cardiometabolic diseases. Phytochemicals are small molecules synthetized by plants for their protection…
- Dietary Patterns in the Ageing European Population: an Interdisciplinary Approach to combat Overweight-Related Metabolic Diseases. The EURODIET project Image AbstractAn epidemic of overweight/obesity, metabolic syndrome and cardio-metabolic diseases is emerging at planetary level, and healthy nutrition represents a critical help to…
- The physiological impact of dietary methylglyoxal Image AbstractBioactive compounds produced during food processing can have strong pro-inflammatory properties with potential health implications. Modulation of chronic inflammation may be the mechanism linking diet to the risk of chronic diseases such as diabetes and cardiovascular…
- Tailored Carbohydrate Quality for Personalized Weight Management and Metabolic Health Image AbstractThis project investigates the role of carbohydrate quality (CQ) on weight management, appetite and cardiometabolic health in humans as well as underlying mechanisms by which CQ affects consumers. It will also promote career…
- Carbohydrate staple foods - facing the challenge to improve their quality for a better metabolic healthAbstract Image Carbohydrates are the main energy source in most European diets. Their metabolic effects depend on several aspects ranging from chemical structure to food matrix and food processing which are best captured by the…