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- The project aimed at evaluating the specific role of selenium (Se) in relation to other nutrients and trace elements in favoring brain and behavioral plasticity. The central hypothesis tested is the role of oxidative stress and inflammation as key processes connecting diet, peripheral tissues and brain development. In our experimental models, pregnant and lactating female rats and their offspring…
- Mitochondria represent central regulators of nutritional homeostasis and of the aging process. Epidemiological studies, including data from our cohort, indicate nutritional risk and preventive factors associated with dietary intake for the development of age-related parameters. Notably, studies from this network revealed the importance of a finely tuned mitochondria-autophagy axis as a preventive…
- Recognition and understanding of intentions are key processes in social cognition. An important neuromodulator regulating social cognition is serotonin, the precursor of which is the essential amino acid tryptophan (TRP). Altered serotonin availability and metabolization is hypothesized for several mental problems, physical illnesses and further also for elderly individuals. Reduced TRP…
- Understanding how diet modifies cognitive ageing represents the next frontiers for developing prevention strategies. A key may rely on elucidating the exact combination of dietary bioactives capable of modulating cognitive decline via brain plasticity, a major compensatory mechanism to maintain cognitive function. Another important question is the sensitive population in which such nutritional…
- The aged brain is particularly vulnerable to stress-induced cognitive decline and will benefit tremendously from mechanistically-oriented dietary interventions to attenuate such cognitive impairment and to provide a general boost to brain health. Moreover, cognitive decline is increasingly present in the ageing population, who are living with chronic diseases and subjected to elevated levels of…
- Determinants of Diet and Physical Activity; Knowledge Hub to integrate and develop infrastructure for research across Europe: From December 2013 until December 2016 the research network ‘DEDIPAC’ was active. DEDIPAC stands for ‘DEterminants of DIet and Physical ACtivity’. The main goal of DEDIPAC was to establish a research network (Knowledge Hub) of researchers from different countries and…
- The aim of the project is to develop a comprehensive toolbox of optimized existing and novel technologies for developing healthy, high quality, safe and sustainable fish products from pelagic fish species. Pelagic fish is rich in omega-3 lipids (EPA and DHA) with documented beneficial health effects, easily digestible proteins; vitamins (E and D). However, during processing; high temperatures…
- The LONGLIFE project involves Irish research partners (Teagasc and UCC) to develop innovative processes for transforming food substrates (milk, Teagasc and cereals, UCC) into fermentates, using novel strains of lactic acid bacteria (LAB) and yeasts to produce value-added fermented liquids and powders, and long-fermented sourdough bread with improved health benefits, improved organoleptic qualities…
- An increased intestinal permeability (IP), also known as leaky gut, could be responsible for activation of the immune system and inflammation, a common mechanism in many chronic age-related diseases. The MaPLE project tested the hypothesis that an increased intake of polyphenol-rich foods can reduce IP and the quantity of inflammogenic bacterial factors in the bloodstream, promoting a protective…
- Background and aimThe human gut microbiota is a complex ecosystem consisting of hundreds to thousands of distinct bacterial species which provide important immune, metabolic and trophic functions for their host. Our knowledge on the processes contributing to microbial dysbiosis has a direct impact on our ability to manage and maintain human health. Early childhood appears a crucial age-window…
- BackgroundBacteria play a crucial role in our healthy development, and in protecting against chronic disease. The goal of EarlyVir was to find out whether the same applies for viruses and if we can isolate important viruses and use them as a technology to improve human health.Objectives:Determine the viral composition of the infant gut at age 1 yearDetermine whether it was influenced by the diet…
- Microbial colonization of the new-born is essential for the development of the physiological homeostasis of the host. Perturbations of early-life colonization may have long-lasting effects on host health; specific alterations seem to precede the development of disease, including both communicable and non-communicable diseases. Thus, early microbiota establishment has a profound effect on long-term…