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- Pregnancy and infancy are critical periods for nutritional programming of metabolic health. Epigenetic changes such as DNA methylation seem to have a crucial role linking early-life nutrition to metabolic health across the life course. The aim of NutriPROGRAM was to identify early-life nutrition-related factors and related epigenetic pathways leading to metabolic adaptations and disease across the…
- Background and aimIn recent decades, nutritional science and biomedicine have made enormous progress in the development of modern molecular and cellular research technologies. This has led to the awareness that health is a state of homeostasis, not only for our various eukaryotic cells, but also for the millions of living microorganisms that live in symbiosis on (e.g. skin) or in (e.g. gut) our…
- Dietary Assessment & Further Development of Biomarkers for All Image AbstractThe role of diet in health is well established and current dietary and lifestyle patterns together with an ageing population has resulted in an increase in the prevalence of diet-related…
- Nutrition and aryl hydrocarbon receptoractivation in mesenteric adipose tissueinflammation and intestinal surgical site Image AbstractObesity and sedentary lifestyles are facing society with an increasing burden of affiliated health problems such as metabolic syndrome, cardiovascular disease, and type 2 diabetes…
- Preventing obesity, sarcopenia, and Sarcopenic Obesity in retirement – digital personalized interventions for healthy NUTrition and physical activity for Seniors Image AbstractThe aging population faces two conditions that threaten healthy aging: high fat mass (obesity) and low muscle mass and function (sarcopenia). The…
- Background and aimThe VALID project aims to validate plasma valerolactones as stable biomarkers of catechin- and procyanidin- rich foods and to demonstrate their association with markers of metabolic health, inflammation and cognitive function in an older European population, building upon the existing TUDA study of 5,186 older adults. The VALID project has 5 objectives, to evaluate:Plasma PVLs…
- Background and aim:Studies suggest that the intestinal microbiome modulates the risk of several chronic diseases, including type 2 diabetes, allergy, cardiovascular disease, and colorectal cancer (CRC). Dietary factors are related to chronic disease risk, and they have been suggested to modulate the composition and function of the gut microbiome. However, detailed knowledge on the relationship of…
- Main objectives/results:SA1- identification of effector proteinsEffector analysis and selection from genome sequenced reference strains:Identification of 77 genome sequenced reference strains for proteobacterial strains isolated from the human gut Application of Machine Learning tools for deeper T3SS screening -> 44 strains with 3000 effectors identified/selectedFunctional (relation to diet…
- A comprehensive study of the innate immune surveillance against infection during postprandial metabolism Image AbstractPostprandial inflammation describes a systemic state of activation of immune cells following the ingestion of macronutrients from food. While this response helps fight infections, it…
