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- Background and aimThe SALAMANDER project aimed at defining salivary signatures indicative of healthy dietary choices (adherence to a Mediterranean diet: MeDi) with a positive long-term health outcome (protection against type 2 diabetes: T2DM).In a discovery phase, 214 subjects were selected in two cohorts of elderly people (3-C Bordeaux in France, Seniors-ENRICA in Spain) following a case-control…
- PREcisE’s goal is to use longitudinal data from the pre-conceptional period up until adulthood to explore the life-course and molecular pathways pertaining the mother to offspring transmissibility of impaired glycaemic health. The project harnesses very large data from cohorts/biobanks from Spain, Germany, Finland, France and the Netherlands. It also joins hands with related projects (e.g…
- Background and aimThe human gut microbiota is a complex ecosystem consisting of hundreds to thousands of distinct bacterial species which provide important immune, metabolic and trophic functions for their host. Our knowledge on the processes contributing to microbial dysbiosis has a direct impact on our ability to manage and maintain human health. Early childhood appears a crucial age-window…
- Early life is fundamental for brain and microbiota development. Gut microbiota influences brain function. Maternal obesity affects maturation of gut microbiota and is an important predictor of cognitive dysfunction in the offspring. Cognitive decline through life is an increasingly invalidating condition, due to population ageing and the high frequency of predisposing factors (obesity, unhealthy…
- Pregnancy and infancy are critical periods for nutritional programming of metabolic health. Epigenetic changes such as DNA methylation seem to have a crucial role linking early-life nutrition to metabolic health across the life course. The aim of NutriPROGRAM was to identify early-life nutrition-related factors and related epigenetic pathways leading to metabolic adaptations and disease across the…