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- Background and aimBile acids (BA) through G protein-coupled bile acid receptor 1 (GPBAR1 or TGR5) and nuclear receptors like Farnesoid X receptor (FXR) regulate mammalian inflammation, and lipid, glucose, energy, and xenobiotic metabolism. The gut microbiota modulates the enterohepatic circulation of BA and microbially produced secondary BA appear to be more potent receptor agonists than primary…
- In 2017 JPI HDHL launched a rapid action call to support a community-led working group that can push forward the field of diet-related chronic diseases. The working group that has been funded started in 2018 for one year.
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The ‘Healthy Diet, Healthy Life’ (HDHL) initiative is looking for candidates for the position of Chair of the Management Board. - Image
Coronary atherosclerosis is a leading global cause of death. While the Mediterranean diet likely benefits patients after Acute Coronary Syndrome (ACS), the underlying microbiome, immune, and metabolic pathways remain unknown. Understanding these mechanisms is vital for improving secondary prevention and disease management. - Image
All projects funded within the HDHL-INTIMIC cofunded call are finished. The call on “Interrelation of the INtesTInal MICrobiome, Diet and Health” was launched in 2017 as part of HDHL-INTIMIC. It was co-funded by the EC, aiming to fund transnational research projects that address the causal relationship of diet, the intestinal microbiome and health. - Image
HDHL-INTIMIC was the second ERA-NET Cofund of JPI HDHL and launched its first call in 2017: Interrelation of the Intestinal Microbiome, Diet and Health. The call was funded by the EC and 8 countries. Supporting 11 research projects, the initiative concluded in December 2022, yielding significant new insights into how nutrition impacts health. - Image
Westernization in Africa increases diabetes and CVD risk. While inflammation is a known driver, gaps remain in understanding how diet and gut microbiota influence immune function. This shift highlights the need to study how lifestyle impacts microbiome-immunity links. - Image
Maternal and infant diets have long-term health effects, including obesity, allergies, and metabolic disorders. However, the exact molecular and cellular mechanisms through which dietary metabolites and contaminants impact health remain unclear. - HDHL-INTIMIC launched the Knowledge Platform call in September 2018. The Knowledge Platform was funded in spring 2019 and started the same year.