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results found for 'Biomarkers'.
- The aim of Meatic project is to understand the role of the gut microbiome as determinant of the effect of diet on colorectal cancer risk and to identify specific associated microbiome profiles. We compared in humans (WP1) and experimental animals (WP2-WP3-WP4), a high-risk meat-based diet (MBD) with a pesco-vegetarian diet (PVD) associated with a lower CRC risk and a MBD diet medium risk…
- Food phytochemicals matter for cardiometabolic health Image AbstractFOODPHYT aims at raising awareness and understanding of the enormous potential of food phytochemicals to support the global fight against obesity and associated cardiometabolic diseases. Phytochemicals are small molecules synthetized by plants for their protection…
- The human gut microbiota has been linked with incidence and progression of noncommunicable diseases and their riskfactors. Moreover, diet has been identified as an important modulator of microbiota composition and function, but responsesvary across individuals.DiGuMet aimed to explore how gut microbiota interacts with diet and the role of such interactions for cardiometabolic diseaserisk and to…
- Dietary Patterns in the Ageing European Population: an Interdisciplinary Approach to combat Overweight-Related Metabolic Diseases. The EURODIET project Image AbstractAn epidemic of overweight/obesity, metabolic syndrome and cardio-metabolic diseases is emerging at planetary level, and healthy nutrition represents a critical help to…
- Background and aimIn recent decades, nutritional science and biomedicine have made enormous progress in the development of modern molecular and cellular research technologies. This has led to the awareness that health is a state of homeostasis, not only for our various eukaryotic cells, but also for the millions of living microorganisms that live in symbiosis on (e.g. skin) or in (e.g. gut) our…
- Background and aimBile acids (BA) through G protein-coupled bile acid receptor 1 (GPBAR1 or TGR5) and nuclear receptors like Farnesoid X receptor (FXR) regulate mammalian inflammation, and lipid, glucose, energy, and xenobiotic metabolism. The gut microbiota modulates the enterohepatic circulation of BA and microbially produced secondary BA appear to be more potent receptor agonists than primary…
- Background and aimHEALTHMARK investigated the complex associations between diet, microbiota, tryptophan metabolites of microbial metabolism, and metabolic health in a set-up of identification, replication, and validation of associations. The project, organized in five work packages (WP) comprised two observational and two intervention studies.In WP1, the University of Bonn (UB) using the DOrtmund…
- A comprehensive study of the innate immune surveillance against infection during postprandial metabolism Image AbstractPostprandial inflammation describes a systemic state of activation of immune cells following the ingestion of macronutrients from food. While this response helps fight infections, it…
