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- Cardiovascular and metabolic diseases are a primary cause of morbidity and mortality worldwide. Diet is a major risk factor for cardio-metabolic health, but is challenging to study in part because metabolic response to diet is highly individualised. Characterising the molecular pathways that mediate personalised responses to diet is critical to effectively tackle the current epidemic. Epigenetic…
- Background and aim There is an urgent need to find reliable early biomarkers of the cardiometabolic syndrome (CardMetS) allowing intervention before irreversible damage develops while assessing the efficacy of nutritional prevention. Oxylipins could be relevant candidate biomarkers thanks to their involvement in the homeostatic regulation of various process related to the cardiometabolic status…
- Background and aimHEALTHMARK investigated the complex associations between diet, microbiota, tryptophan metabolites of microbial metabolism, and metabolic health in a set-up of identification, replication, and validation of associations. The project, organized in five work packages (WP) comprised two observational and two intervention studies.In WP1, the University of Bonn (UB) using the DOrtmund…
- Background and aimFAME aimed to a) identify novel lipidomics biomarkers as biomarkers of fatty acid status and of future cardiometabolic clinical events, b) establish relationships between diet and tissue status of fatty acids as explanatory factors for diet relationships with cardiometabolic health, and c) to investigate genetic determinants of fatty acid status and metabolism which modify the…
- PROtein enriched MEDiterranean diet to combat undernutrition and promote healthy neuroCOGnitive ageing in older adults Image AbstractThe PROMED-COG project aims to (i) increase knowledge on the balance between the Mediterranean diet (MedDiet) and physical activity for prevention of undernutrition and promotion ofhealthy…
- BackgroundBacteria play a crucial role in our healthy development, and in protecting against chronic disease. The goal of EarlyVir was to find out whether the same applies for viruses and if we can isolate important viruses and use them as a technology to improve human health.Objectives:Determine the viral composition of the infant gut at age 1 yearDetermine whether it was influenced by the diet…
