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results found for 'Immune system'.
- A comprehensive study of the innate immune surveillance against infection during postprandial metabolism Image AbstractPostprandial inflammation describes a systemic state of activation of immune cells following the ingestion of macronutrients from food. While this response helps fight infections, it…
- Preventing peanut allergy through improved understanding of the transcutaneous sensitisation route, novel food processing and skin care adaptations Image AbstractAllergic diseases, including atopic dermatitis (AD, also called ‘atopic eczema’) and food allergies (FA), affect over a quarter of all children across Europe…
- BackgroundBacteria play a crucial role in our healthy development, and in protecting against chronic disease. The goal of EarlyVir was to find out whether the same applies for viruses and if we can isolate important viruses and use them as a technology to improve human health.Objectives:Determine the viral composition of the infant gut at age 1 yearDetermine whether it was influenced by the diet…
- Nutrition and aryl hydrocarbon receptoractivation in mesenteric adipose tissueinflammation and intestinal surgical site Image AbstractObesity and sedentary lifestyles are facing society with an increasing burden of affiliated health problems such as metabolic syndrome, cardiovascular disease, and type 2 diabetes…
- An increased intestinal permeability (IP), also known as leaky gut, could be responsible for activation of the immune system and inflammation, a common mechanism in many chronic age-related diseases. The MaPLE project tested the hypothesis that an increased intake of polyphenol-rich foods can reduce IP and the quantity of inflammogenic bacterial factors in the bloodstream, promoting a protective…
- The aged brain is particularly vulnerable to stress-induced cognitive decline and will benefit tremendously from mechanistically-oriented dietary interventions to attenuate such cognitive impairment and to provide a general boost to brain health. Moreover, cognitive decline is increasingly present in the ageing population, who are living with chronic diseases and subjected to elevated levels of…
- The main objectives of the OCTOPUS project were:to determine, in mouse models, to what extent apoA-I/HDL modulate gut microbiota composition, intestinal homeostasis/immunity, plasma metabolome and atherosclerosis development.to determine whether apoA-I/HDL levels modulate gut microbiota composition and plasma metabolome in human cohorts, and to identify possible correlations between microbiota…
- The project aimed at evaluating the specific role of selenium (Se) in relation to other nutrients and trace elements in favoring brain and behavioral plasticity. The central hypothesis tested is the role of oxidative stress and inflammation as key processes connecting diet, peripheral tissues and brain development. In our experimental models, pregnant and lactating female rats and their offspring…
- Background and aimBile acids (BA) through G protein-coupled bile acid receptor 1 (GPBAR1 or TGR5) and nuclear receptors like Farnesoid X receptor (FXR) regulate mammalian inflammation, and lipid, glucose, energy, and xenobiotic metabolism. The gut microbiota modulates the enterohepatic circulation of BA and microbially produced secondary BA appear to be more potent receptor agonists than primary…
- Background and aimIn recent decades, nutritional science and biomedicine have made enormous progress in the development of modern molecular and cellular research technologies. This has led to the awareness that health is a state of homeostasis, not only for our various eukaryotic cells, but also for the millions of living microorganisms that live in symbiosis on (e.g. skin) or in (e.g. gut) our…
