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- The aged brain is particularly vulnerable to stress-induced cognitive decline and will benefit tremendously from mechanistically-oriented dietary interventions to attenuate such cognitive impairment and to provide a general boost to brain health. Moreover, cognitive decline is increasingly present in the ageing population, who are living with chronic diseases and subjected to elevated levels of…
- Background and aimBile acids (BA) through G protein-coupled bile acid receptor 1 (GPBAR1 or TGR5) and nuclear receptors like Farnesoid X receptor (FXR) regulate mammalian inflammation, and lipid, glucose, energy, and xenobiotic metabolism. The gut microbiota modulates the enterohepatic circulation of BA and microbially produced secondary BA appear to be more potent receptor agonists than primary…
- The human gut microbiota has been linked with incidence and progression of noncommunicable diseases and their riskfactors. Moreover, diet has been identified as an important modulator of microbiota composition and function, but responsesvary across individuals.DiGuMet aimed to explore how gut microbiota interacts with diet and the role of such interactions for cardiometabolic diseaserisk and to…
- Dietary Patterns in the Ageing European Population: an Interdisciplinary Approach to combat Overweight-Related Metabolic Diseases. The EURODIET project Image AbstractAn epidemic of overweight/obesity, metabolic syndrome and cardio-metabolic diseases is emerging at planetary level, and healthy nutrition represents a critical help to…
- Determinants of Diet and Physical Activity; Knowledge Hub to integrate and develop infrastructure for research across Europe: From December 2013 until December 2016 the research network ‘DEDIPAC’ was active. DEDIPAC stands for ‘DEterminants of DIet and Physical ACtivity’. The main goal of DEDIPAC was to establish a research network (Knowledge Hub) of researchers from different countries and…
- The project aimed at evaluating the specific role of selenium (Se) in relation to other nutrients and trace elements in favoring brain and behavioral plasticity. The central hypothesis tested is the role of oxidative stress and inflammation as key processes connecting diet, peripheral tissues and brain development. In our experimental models, pregnant and lactating female rats and their offspring…
- Background and aimIn recent decades, nutritional science and biomedicine have made enormous progress in the development of modern molecular and cellular research technologies. This has led to the awareness that health is a state of homeostasis, not only for our various eukaryotic cells, but also for the millions of living microorganisms that live in symbiosis on (e.g. skin) or in (e.g. gut) our…
