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- Background and aimSub-optimal status of Riboflavin (vitamin-B2) may be more widespread than generally recognised because of reliance on dietary data only in many nutrition surveys and lack of reliable biomarker data. The DERiVE project aimed to address this by developing accessible riboflavin biomarkers and by demonstrating important functional, gene-nutrient and health effects of optimal…
- Food phytochemicals matter for cardiometabolic health Image AbstractFOODPHYT aims at raising awareness and understanding of the enormous potential of food phytochemicals to support the global fight against obesity and associated cardiometabolic diseases. Phytochemicals are small molecules synthetized by plants for their protection…
- Background and aimBile acids (BA) through G protein-coupled bile acid receptor 1 (GPBAR1 or TGR5) and nuclear receptors like Farnesoid X receptor (FXR) regulate mammalian inflammation, and lipid, glucose, energy, and xenobiotic metabolism. The gut microbiota modulates the enterohepatic circulation of BA and microbially produced secondary BA appear to be more potent receptor agonists than primary…
- Early life is fundamental for brain and microbiota development. Gut microbiota influences brain function. Maternal obesity affects maturation of gut microbiota and is an important predictor of cognitive dysfunction in the offspring. Cognitive decline through life is an increasingly invalidating condition, due to population ageing and the high frequency of predisposing factors (obesity, unhealthy…
- Background and aimAccording to the Developmental Origins of Health and Disease hypothesis early life exposure to environmental factors plays a critical role in defining offspring health in childhood and later life. Thus adaptation to suboptimal nutrition during pregnancy or early childhood may perpetuate intergenerational transmission of a range of adverse health outcomes. Epigenetic phenomena…
- Background and aimThe Joint Programming Initiative on a Healthy Diet for a Healthy Life (JPI HDHL), involved 28 research institutes from seven European countries and New Zealand combined their expertise to form the Policy Evaluation Network (PEN). PEN, true to its vision, has improved knowledge, tools and capacity among its network and beyond to identify, evaluate and benchmark policies designed…
